The purpose of the study is to develop a method of perioperative energy monitoring and to implement it in clinical practice. Material and methods. The study involved 125 patients who underwent various surgical interventions under general anesthesia using sevoflurane (inhalation anesthetics) and fentanyl (narcotic analgesics) in low-flow artificial lung ventilation. Methods of perioperative monitoring (International Standards for a Safe Practice of Anesthesia 2010, WFSA) were supplemented using indirect calorimetry. Results. Analyzing the literature data, a close correlation was found between the energy equivalent of oxygen (EEE2) and the respiratory factor (RQ). The authors obtained the corresponding one-factor linear regression formula, which had the form: EEE2 = 1.157 × RQ + 4,037. Using the basic principles of gas exchange in the lungs of Bohr-Engoff, a method of perioperative energy monitoring was developed, based on indirect calorimetry, taking into account the real values of the energy equivalent of patients' oxygen. The universal formula for determining the level of metabolism of the patient (MR, cal / min) in the form of: MR = [0,863 × VE × (PECO2 / PaCO2) × (FiO2 - FeO2)] (1,157 × RQ + 4,037) where, VE - total ventilation of the lungs per minute (ml / min), PECO2, PaCO2 - partial pressure, respectively, in a mixture of gases, which is exhaled and in the arterial blood (mm Hg). FiO2 and FEO2 are the oxygen fraction in the gas mixture that is inhaled and exhaled in units (% / 100). The method is implemented as a computer program created on the basis of the developed formula. The methods of intensive perioperative therapy taking into account the level of metabolism are presented. Conclusion. The method of perioperative energy monitoring substantially complements the "International Standards for Safe Anesthesiology Practice", WFSA (2010) enhances the perioperative safety of patients by detecting metabolic disorders and conducting appropriate pathogenetic correction.
Secondary hyperparathyroidism (SHPT) affects a majority of patients with chronic kidney disease (CKD) of stage 3 or worse with manifestations of chronic renal failure (CRF) who undergo hemodialysis. Most of them have severe metabolic disorders, metabolic acidosis and a range of disorders associated with hyperparathyroidism and require parathyroid surgery (PTS). Aim of research. To assess the possibilities of metabolic correction in patients with SHPT with PTS, depending on the level of blood cortisol. Materials and methods. The study was carried out in the clinic of SIS «RPC PCM» SAD, Kyiv, Ukraine, was prospective, not randomized. The study group (n=133) included patients with severe SHPT manifestations due to end-stage chronic renal failure due to CKD, who underwent PTS. Patient age: 21-75 years old. Men – 69 (51,9%), women – 64 (48,1%). The degree of preoperative risk of ASA III-IV. Surgical interventions were performed under general anesthesia using the inhalation anesthetic sevoflurane and the narcotic analgesic fentanyl under conditions of low-flow artificial ventilation. The patients underwent a personalized energy monitoring developed and implemented in our clinic, using indirect calorimetry, by determining the index of current metabolism (Metabolic Rate Index, MRI, cal min-1 m2 ), basal metabolism (Basal Metabolic Rate Index, BMRI, cal min-1 m2), target metabolism (Target Metabolic Rate Index) and severity of metabolic disorders (Metabolic Disordes, MD,% = ). The patients were divided into two groups. The first group (I,72) consisted of patients who had reference values of the morning blood cortisol level before the operation – 171,03 and higher (173-374) nmol/L. The second group (II, 61) consisted of patients who had cortisol levels below this limit (91,5-168 nmol/L). In group I, intensive perioperative therapy was standard and aimed at supporting and correcting vital signs, according International Standards for a Safe Practice of Anesthesia 2010, WFSA. In group II, patients additionally received intravenous drip of 125-250 mg of prednisolone and further situationally hydrocortisone under the control of energy monitoring indicators. Results. In 45.9% of patients with SHPT and end-stage CKD, glucocorticoid insufficiency and low metabolic rate were diagnosed, which can lead to irreversible changes in organs or the life support system and increase the risks of perioperative complications and death in PTS. Preventive and perioperative administration of glucocorticoids under the control of energy monitoring, restores homeostasis indicators. Patients with normal blood cortisol levels did not have significant metabolic disorders. It was enough for them to follow the standard protocol of perioperative intensive care. Conclusions. Mandatory preoperative monitoring of blood cortisol levels in patients with SHPT against the background of end-stage CKD, who are on programmed hemodialysis, who are planned for PTS, is required in order to achieve a differential approach to treatment: to determine the need and dose of intravenous glucocorticoids.
In the past, thyroid surgery has been the most common cause of thyroid storm, but recently, preoperative drugs that create a euthyroid state before surgery have somewhat improved treatment outcomes. Therefore, the anesthesia of such operations is very important. The aim of this work: to evaluate the possibility of using dexmedetomidine for perioperative correction of metabolism in thyroidectomy under general anesthesia in patients with thyrotoxicosis. Materials and methods. The study was prospective, not randomized. The study involved 137 patients (53 men, 84 women, aged 21 to 76 years) with thyrotoxicosis, who underwent planned thyroidectomy under general anesthesia, using the inhalation anesthetic sevoflurane and the narcotic analgesic fentanyl, in low-flow artificial lung ventilation. Perioperative monitoring was complemented by the use of indirect calorimetry. The degree of preoperative risk of patients is ASA III-IV. In group I (n=71), situationally, during the operation, with a heart rate of > 90 beats/min, a selective β-blocker esmolol hydrochloride was administered intravenously (25-50 μg×kg-1×min-1) under the control of ECG and hemodynamic parameters until the heart rate normalizes. In group II (n=66) - dexmedetomidine – 0,1 μg×kg-1×h-1. Results and discussions. The initial metabolic parameters in both groups were high and amounted, respectively, 830±15 cal×min-1×m-2 in group I and 832 ± 13 cal×min-1× m-2 in group II, which exceeded their basal metabolic rate: in group I - by 54,9% and in group II - by 58,5% (p <0.01). At the stage of induction of anesthesia in group I, a depression of the hemodynamic profile was revealed, probably associated with the effect of the introduction of esmolol hydrochloride, which led to a decrease in oxygen transport without metabolic disturbances. At the stages of mobilization and removal of the thyroid gland, manifestations of hyperdynamia and hypermetabolism were observed in both groups. Metabolism at these stages, in group II, respectively, was lower, by 9,3% and 10,1%, than in group I. The degree of metabolic disorder, in group I, was 42,8% ± 2,3 % and 32,6 ± 1,8%, in group II – 31,2 ± 1,6% and 22,3 ± 1,2% (p <0.05). The blood cortisol level in group I was higher than in group II (p <0.05). Conclusions. Perioperative energy monitoring using indirect calorimetry allows timely detection of metabolic disorders and appropriate pathogenetic correction. The use of dexmedetomidine at a dose of 0.1 μg × kg-1 × h-1 is quite effective as an intravenous adjuvant for general anesthesia during thyroidectomy in patients with thyrotoxicosis.
Summary: Premedication – medical and non-medical preparation of the patient for surgery or examination, which will take place with The study of perioperative changes in metabolism in patients undergoing laparoscopic surgical interventions for esophageal hiatal hernia (EHH) is relevant. The aim of the study. To study the perioperative metabolism in patients with EHH and evaluate the possibilities of its correction. Material and methods. The study was prospective, not randomized. 127 patients, aged 31-76 years, who underwent laparoscopic operations in connection with EHH, were studied (m-59, w-68). Preoperative risk ASA II-III. General anesthesia using the inhaled anesthetic sevoflurane and the narcotic analgesic fentanyl in conditions of low-flow artificial lung ventilation. Perioperative intensive care was carried out in accordance with the International Standards of Safe Anesthesiological Practice of the WFSA (World Federation of Societies of Anesthesiologists, 2010). In group I (n=61), a retrospective energy audit was carried out according to protocols for analgesia of medical charts and calculations of indirect calorimetry with determination of current metabolism (CM) and basal metabolism (BM). In group II (n=66), operational monitoring was supplemented with the use of indirect calorimetry with the determination of CM, BM, target metabolism (TM) and the degree of metabolic disturbance (DMD = 100×(TM-CM) / TM) %, and intensive therapy was supplemented additional infusion therapy and glucocorticoids, accordingly to the dynamics of metabolic changes. The results. The initial indicators of metabolism, in both groups, were without disturbance and significantly exceeded the basal level (in group I – by 30.5%, in group II – by 28.8%) and had the following values: in group I – 749±12 cal× min-1×m-2, in group II – 756±13 cal×min-1×m-2. In both groups, at the stage of reverse Trendelenburg position, imposition of pneumoperitoneum and the beginning of the operation, there were significant metabolic disturbances with a decrease to the basal level. In patients of group I, a slow recovery of PM was observed, the value of which at the moment of awakening remained 7.6% lower than the initial one (p<0.05). In patients of group II, against the background of increased infusion therapy and administration of glucocorticoids, PM recovery was more intense, and, at the moment of awakening, its value exceeded the corresponding value of group I by 10.4% (р<0.05). At the same time, CM and SPM were not high and did not differ from the initial values. Patients of group II, compared to group I, woke up faster and were transferred to the ward, and nausea and vomiting were 2.7 times less frequent: 7.35% in group II and 19.7% in group I (p<0, 05). After 6 and 12 hours after waking up, the feeling of pain on the VAS scale in group II was lower than in group I, respectively, by 24.3% and 34.4% (p < 0.05). Conclusions. Perioperative energy monitoring makes it safer to perform laparoscopic surgery in patients with EHH. Additional definition of the target metabolism and the degree of metabolic disturbance allows more effective construction of perioperative intensive therapy
The aim: To study possibilities of using perioperative energy monitoring in intensive care in patients with acute calculous cholecystitis (ACC). Materials and methods: 131 patients with ACC, who underwent laparoscopic cholecystectomy (LC) under general anesthesia were studied. Risk of ASA II-IV. Group I (n = 63) - intensive care aimed at maintaining vital functions. Group II (n = 68) - additional use of indirect calorimetry data. Results: At the stages of the reverse position of Trendelenburg, pneumoperitoneum and the beginning of the operation, a decrease in hemodynamic, a violation of the oxygen status and metabolism were observed with more pronounced manifestations in the I group, where there was a longer recovery. In patients of group II, on the background of enhanced infusion therapy and administration of glucocorticoids, their recovery was more intense, they woke up faster and were transferred to the ward. These patients had 2,4 times less nausea and vomiting, and less postoperative pain upon awakening (p<0,05). Conclusions: In patients with ACC, correction of hemodynamic, oxygen status and metabolism, makes LC safer.
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