The results of surgical antibacterial rehabilitation and drainage of liver abscess largely depend on the effectiveness of local action of drugs. A promising direction in experimental liver abscess surgery is the local application of laser and nanotechnology. - The goal is to experimentally substantiate the effectiveness of the combined use of low-intensity laser radiation and copper nanoparticles in the surgical treatment of liver abscesses. Material and methods. In an experiment on 80 laboratory rabbits, a classic liver abscess was modeled. According to the variant of local two-week treatment, the animals were divided into 4 groups of 20 each. Animals of the first group were given daily standard sanitation of the cavity with an antiseptic solution; in the second group, low-intensity laser irradiation was locally administered; animals of the third group, the cavity of the abscess was washed with a suspension of copper nanoparticles; in the fourth group of animals, treatment with a suspension of copper nanoparticles in combination with low-intensity laser irradiation was applied. Clinical, planimetric, microbiological, morphological and instrumental research methods were used to evaluate the results of treatment. Results and discussion. The best clinical indicators of general condition by the 9th day were observed in the treatment of animals of the fourth group. Due to the active stimulation of reparative processes, by the 7th day of treatment of animals of this group, no aspirate cultures from the growth abscess cavity were given, which made it possible to speed up the closure of the purulent cavity, which by the 21st day according to ultrasound planimetry, the abscess cavity of the liver was completely obliterated. Conclusion. Used clinical and instrumental methods of research are effective ways to assess the results of treatment of simulated purulent cavity of the liver. The combined surgical treatment of simulated liver abscesses with topical application of uniformly scattered LLLT and copper nanoparticles provides accelerated cleansing of the abscess cavity causative agent and complete obliteration of the abscess cavity.

Goal. Develop a model of purulent liver abscess (GAP), which corresponds to all the classic signs of a delimited abscess. Material and methods. Simulation of GAP was carried out in an experiment on 60 laboratory animals. Under ultrasound control (UC), a double-lumen Fogerty catheter was inserted into the established portion of the liver, a cystic cavity was formed in 3 days, which was infected and after 3 days GAP was obtained. In the modeling of GAP, clinical, planimetric, microbiological, morphological and instrumental methods of investigation were used. Results. On the third day of the experiment, a round cystic cavity of the liver with a diameter of 1,8 cm3 was formed. Three days after infection, a classic purulent abscess develops, surrounded by a dense wall formed from the liver parenchyma. As a result of the experiment, a clinical, microbiological, morphological and instrumental justification for modeling GAP with all its classic features was obtained. The conclusion. The proposed method for modeling purulent liver abscess is economically and technically profitable, minimally traumatic, provides guaranteed formation of classical GAP in the shortest possible time.

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