We report on a 13 year old girl with a FSH, secreting pituitary tumour, who was presented with recurrent bleeding disorders. Gynaecological examination revealed large cystic ovarian tumours on both sides. The endocrinological work-up showed high serum levels of oestradiol and FSH, and low serum levels of testosterone and LH. Computed tomography demonstrated a pituitary tumour of 3 cm diameter.
D-Ser (TBU)6 LH-RH 1\ p=n-\ 9 (EA)10 (HOE 766) a highly active LH-RH analogue, was studied with regard to its effects on the release of follicle stimulating hormone (FSH), luteinizing hormone (LH) and oestradiol-17\g=b\ (Oe2) during the follicular phase of the menstrual cycle. Forty-two regularly menstruating women were allowed to five different treatment groups with different doses (1.25 \g=m\g;2.5 \g=m\g; 5.0 \g=m\g; 10.0 \g=m\g; 20.0 \g=m\g) of HOE 766 given as intravenous bolus injections and the plasma concentrations of FSH, LH and Oe2 were measured up to 24 h after injection using specific radioimmunoassays. In the majority of cases, peak values of both FSH and LH occurred 4 h after injection being significantly different from pre-injection levels (P < 0.02 in the 1.25 \g=m\g treatment group, P < 0.005 for the other treatment groups). Statistical analysis of maximum values as well as the absolute and relative increase in the different treatment groups revealed a dose-dependent effect of HOE 766. Maximum values of Oe2 occurred 8 h after injection and were found to be significantly different from pre-injection levels (P < 0.005). However,
Abb. 2). Der Unterschied entspricht dem Unterschied zwischen Gruppe WHO I und WHO II mit normalen Prolaktinwerten.Auf Grund dieser Ergebnisse schlagen wir vor, auch bei Patientinnen der Gruppe WHO V und VI mit erh6htem Prolaktin anzugeben, ob sie funktionell der Gruppe I = clomiphennegativ oder der Gruppe II = clomiphenpositiv entsprechen, um eine bessere internationale Vergleichbarkeit der Sterilit/itstherapie zu erzielen. Die.H6he des Prolaktinwerts kann zur Definition des Schweregrads der Amenorrhoe nicht herangezogen werden, da die H6he des Prolaktinwerts nicht mit dem Anstieg des LH im GnRH-Test korreliert.
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