The present investigation was undertaken in order to achieve a better understanding of the dynamics of placental villous differentiation. Villous trees from human placentas from different stages of pregnancy (first trimester to full term) were isolated and studied by light microscopy and scanning electron microscopy. For light microscopy the trees were serially sectioned and two-dimensionally reconstructed. For scanning electron microscopy complete villous trees or freeze-cracked villi were studied. The most important finding was that the mesenchymal villi are continuously newly formed out of the trophoblastic sprouts throughout pregnancy. Because of this they exist in all stages of pregnancy and have to be considered the basis for growth and differentiation of the villous trees. In the first two trimesters they are the forerunners of the immature intermediate villi, whereas in the last trimester the mesenchymal villi are transformed into mature intermediate villi. The immature intermediate villi formed during the first two trimesters are developmental steps towards the stem villi. On the other hand, the mature intermediate villi, which only are developed during the last trimester, produce numerous terminal villi. The latter are not active outgrowths caused by proliferation of the trophoblast, but rather passive protrusions induced by capillary coiling due to excessive longitudinal growth of the fetal capillaries within the mature intermediate villi.

Fin whales (Balaenoptera physalus) are the only mysticete regularly found in the Mediterranean Sea. Its exceptional high abundance during the summer period in the north-western Mediterranean is essentially due to productive waters, but outside of this spatio-temporal window its distribution still remains quite unknown. This paper investigates the distribution of the fin whale on large-scales during the 2002-2006 period. Three areas of the central Mediterranean Sea were selected: the Ligurian Sea in the north-western Mediterranean belonging to the Pelagos Sanctuary; the area connecting both Mediterranean basins in the south-western Mediterranean, the Strait of Messina; and the waters surrounding the island of Lampedusa, in the central Mediterranean. Of the 41,270 km covered by the three surveys, a total of 98 sightings was recorded corresponding to 198 fin whales. Results display a year round distribution along synchronic seasonal dispatching, with a feeding behaviour occurrence in the northern part of the Pelagos Sanctuary during late spring and summer. They indicate high abundance in the Lampedusa area from late winter to early spring manifesting feeding activity. In the Strait of Messina, our results point out the importance of this area as a seasonal feeding ground and an important location for regular autumn transfers between both Mediterranean basins. According to the feeding ground in the two Mediterranean basins, whales change foraging strategy, one being single animals or animal pairs searching for prey in the water column while the other strategy is associated with more individuals feeding on the surface. The strategies differ also by their ecological conditions, such as depth affinity and shoreline distance.

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Chanarin-Dorfman disease (CDD) is a rare genetic disorder characterized by ichthyosis, myopathy, central nervous system disturbances, and intracellular lipid storage in muscle fibers, hepatocytes, and granulocytes. We describe skeletal muscle magnetic resonance imaging findings in a case of CDD, outlining the potential role of GE T1-weighted opposed-phase sequence (chemical shift imaging) in the evaluation of lipid storage myopathies.

Two cases of previously unreported simultaneous presence of A and B postaxial polydactyly in two brothers out of 12 affected members of a kindred are reported. The findings are consistent with the hypothesis that in this family A and B types of postaxial polydactyly are caused by a single gene rather than by two different genes.

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