Cortical Hyperostosis after Long-Lasting Prostaglandin E1 Treatment in a Newborn with Complex Congenital Heart Disease

Celona, A.; Giardina, Claudio; Pappalardo, Salvatore; Secinaro, Aurelio; Oreto, Lilia; Agati, Salvatore; Romeo, Placido

doi:10.1016/j.jpeds.2020.07.067

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…This association has been described and classically imaged with conventional radiology. Being familiarized with this condition in MRI is relevant, as these patients can be studied for other reasons 2 . The differential diagnosis mainly includes infections, metabolic disorders, chronic inflammatory disorders, and cystic fibrosis 3 …”

Section: Figmentioning

confidence: 99%

Prostaglandin E1‐induced periostitis in a neonate with congenital heart disease

Sá

Dias

Costa

et al. 2022

Pediatrics International

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Section: Figmentioning

confidence: 99%

Prostaglandin E1‐induced periostitis in a neonate with congenital heart disease

Sá

Dias

Costa

et al. 2022

Pediatrics International

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“…lasting several weeks, features of osteoarthropathy (mainly clubbed fingers), which did not result from the underlying heart disease, were found. On the other hand, the complaints were related to the duration of the prostacyclin infusion and not to the total dose of the drug [ 16 ]. The described pathogenesis of the disease, related to the increased PGE2 concentrations, corresponds well with the fact that the history of patent ductus arteriosus is more frequent in children with primary hypertrophic osteoarthropathy.…”

Section: Introductionmentioning

confidence: 99%

Primary hypertrophic osteoarthropathy – a rare cause of pain and arthritis in children. Description of 5 cases

Wójtowicz¹,

Kołodziejczyk²,

Gazda³

et al. 2022

cejoi

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Primary hypertrophic osteoarthropathy (PHoa) is a very rare disease. the typical triad of symptoms, i.e. digital clubbing, periosteal bone formation with bone and joint deformities and skin hypertrophy, may be accompanied by other specific conditions. in the majority of patients, the picture of the disease is incomplete. the dominant clinical symptom may be osteoarticular complaints. Moreover, the final confirmation of the diagnosis of the primary form of hypertrophic osteoarthropathy requires the analysis of much more frequent secondary causes of the disease. diagnosing primary osteoarthropathy in children is particularly difficult. some children report joint pain before the onset of the other symptoms of osteoarthropathy, while the physical and imaging examinations show features of arthritis. this can lead to misdiagnoses including the diagnosis of juvenile idiopathic arthritis (Jia) and the unnecessary use of immunosuppressive treatment.the present description of five patients from the Paediatric rheumatology department indicates diagnostic difficulties in children with PHoa. all of them were examined due to pain and features of arthritis. We observed an incomplete clinical picture of the disease. one patient required a revision of the previous diagnosis of Jia and discontinuation of ineffective treatment with disease-modifying antirheumatic drugs (dMards).PHoa should always be considered in the differential diagnosis of arthritis in children, due to the slow and often atypical development of symptoms, including the presence of pain and arthritis as the predominant symptom of the disease.

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Alprostadil

2020

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Cortical Hyperostosis after Long-Lasting Prostaglandin E1 Treatment in a Newborn with Complex Congenital Heart Disease

Cited by 3 publications

References 4 publications

Prostaglandin E1‐induced periostitis in a neonate with congenital heart disease

Prostaglandin E1‐induced periostitis in a neonate with congenital heart disease

Primary hypertrophic osteoarthropathy – a rare cause of pain and arthritis in children. Description of 5 cases

Alprostadil

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