Air permeability and liquid penetration of tablets of sucrose and lactose have been measured. The tablets had been compressed over a wide pressure range from granules which varied in bulk density, size and strength. The degree to which inter‐ and intra‐granular pore structure within the tablet was sustained varied with these properties; low pressure, high density, high strength and large size promoting a more open but less uniform structure. Such structures allowed rapid penetration of liquid through a coarse pore network which isolated a large fraction of the total pore space. Thus tablets of high permeability gave low final degrees of saturation whereas less permeable tablets became fully saturated.
A specific quantitative chromatographic assay method is described for 5-hydroxymethylfurfuraldehyde (SHMF) in degraded D-glucose solutions incorporating an internal standard. Comparison is made between the chromatographic method and the official direct ultraviolet absorption measurements at 284nm for solutions of D-glucose degraded to different extents. Hospital samples of autoclaved Dextiose Injection, 5% w/v, are also examined by both methods and it is demonstrated that quite different results can be obtained depending upon the conditions af measurement. It is demonstrated that the direct absorption method does not provide an adequate limit test for compounds related to 5HMF. An hplc study of the initial stages of dextrose decomposition in neutral solution.Journal ofPharmocyand PharmacoloD, 30, 510-511. 6 . Tahir, A.M. & Cates, D.M. (1974) A spectrophotomeuic investigation of the yellow colour that accompanies the formation of furan derivatives in degraded sugar solutions. Curbohydrarc Research, 34, 249 -262.
The pore structure of tablets has been investigated by mercury porosimetry. Tablets, when prepared from ungranulated powder, showed a narrow pore size distribution, the mode of which decreased from 9 to 1 μm over the pressure range studied. Granulation caused the size distribution of tablet pores to widen. Large robust granules, compressed at low pressures, gave tablets with a bimodal pore size distribution. Decrease in granule size and strength, promoted a more uniform tablet structure and fine, friable, granules, compressed at high pressures, gave tablets with almost the same structure as those prepared from ungranulated powder.
The conditions of wet granulation influenced the pore structure of lactose tablets, prepared over a wide range of tabletting pressures. Dry granulation, on the other hand, only influenced pore structure when slugging pressures were high, the granules were coarse and tabletting pressures were low. Mercury porosimetry revealed intense granule fragmentation when dry granulated materials were compressed. The effect of the change of pore size distribution on liquid penetration into tablets is discussed.
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