An investigation of the pore structure of tablets of sucrose and lactose by mercury porosimetry

Selkirk, A.B.; Ganderton, D.

doi:10.1111/j.2042-7158.1970.tb08584.x

Cited by 35 publications

(9 citation statements)

References 2 publications

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“…Lactose is known to form slowly disintegrating tablets, because it is slow in wetting leading to formation of less porous tablets. Referring to a previous study (Selkirk & Ganderton, 1970), where tablets formed of lactose were compared with those formed of sucrose, lactose containing tablets showed lower percentage of pores when measured using mercury porosimetry. So the lactose containing tablets contain less pores and this led to increase in wetting time.…”

Section: Wetting Timementioning

confidence: 99%

A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation

2016

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Context: Muscle spasm needs prompt relief of symptoms. Chlorzoxazone is a centrally muscle relaxant. Objectives: The aim of this study was to prepare chlorzoxazone orodispersible tablets (ODTs) allowing the drug to directly enter the systemic circulation and bypassing the first-pass metabolism for both enhancing its bioavailability and exerting a rapid relief of muscular spasm. Materials and methods: ODTs were prepared by direct compression method using Pharmaburst Õ 500, Starlac Õ , Pearlitol flash Õ , Prosolv Õ odt and F-melt Õ as co-processed excipients. Three ratios of the drug to the other excipients were used (0.5:1, 1:1 and 2:1). Results and Discussion: All ODTs were within the pharmacopeial limits for weight and content. ODTs containing Pharmaburst Õ 500 showed the shortest wetting time ($45.33 s), disintegration time (DT) ($43.33 s) and dissolution (Q 15min 100.63%). By increasing the ratio of CLZ: Pharmaburst Õ 500 from 0.5:1 to 1:1 and 2:1, the DT increased from 26.43 to 28.0 and 43.33 s, respectively. By using Prosolv Õ odt, ODTs failed to disintegrate in an acceptable time4180 s. DT of ODTs using different co-processed excipients can be arranged as follows: PharmaburstPharmacokinetic study of the optimum formula F1 (50 mg CLZ) in rabbits using HPLC-UV detector revealed a shorter T max (0.333 h) compared with Myofen Õ capsules (250 mg CLZ) (1.083 h) which is considered a promising treatment, especially for the rapid relief of muscle spasm. Conclusion: It could be concluded that orodispersible tablets are a promising carrier for CLZ designed for management of muscle spasm due to the enhanced dissolution and rapid absorption of the drug through the oral mucosa.

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Section: Wetting Timementioning

confidence: 99%

A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation

2016

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“…Wet granulation methods have been reported to promote a coarser, wider pore size distribution which would result in a more permeable tablet (Selkirk and Ganderton, 1970).…”

Section: Introductionmentioning

confidence: 99%

“…The properties of granules and their tablets are influenced by both the formulation and process (manufacturing) variables. Wet granulation methods have been reported to promote a coarser, wider pore size distribution which would result in a more permeable tablet (Selkirk and Ganderton, 1970).…”

Section: Introductionmentioning

confidence: 99%

Formulation studies on Datura metel Linn. Powder 1. Effect of powder size on granule and compact properties

Femi-Oyewo

Elujoba

Alebiowu

1993

Phytotherapy Research

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Datura metel Linn. powdered leaf (25% w/w) has been formulated in lactose-based granulations into compacts using the wet granulation process. The effects of changes in the particle size of D. metel powder on the properties of its granules and compacts were studied. Bigger and less friable granules were produced with increase in powder size due to the increased wettability of the powder with size. These resulted in stronger and less friable compacts with a longer disintegration time. Granule flow rate increased while angle of repose decreased with increase in D. metel powder size. Compacts of comparable physical properties were produced from both granulations of D. metel and D. stramonium. The hyoscine contents of D. metel and D. stramonium powders were found to be 0.23% and 0.30% w/w, respectively.

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“…The solvent penetration rate, in turn, was shown to be intimately related to the volume and size of tablet pores (1)(2)(3)(4)(5)(6). In tablet disintegration and dissolution, the initial stage is probably typically the penetration of the solvent medium into the tablet through the tablet pore system.…”

mentioning

confidence: 99%

Determination of Porosity and Pore-Size Distribution of Aspirin Tablets Relevant to Drug Stability

Gucluyildiz¹,

Banker

Peck

1977

Journal of Pharmaceutical Sciences

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An investigation of the pore structure of tablets of sucrose and lactose by mercury porosimetry

Cited by 35 publications

References 2 publications

A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation

A pharmaceutical study on chlorzoxazone orodispersible tablets: formulation, in-vitro and in-vivo evaluation

Formulation studies on Datura metel Linn. Powder 1. Effect of powder size on granule and compact properties

Determination of Porosity and Pore-Size Distribution of Aspirin Tablets Relevant to Drug Stability

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