No abstract

Cortical Spreading Depression (CSD) is a disruption of the brain he-mostasis that, originating in the visual cortex and traveling towards the frontal lobe, temporarily impairs the normal functioning of neurons. Although , as of today, little is known about the mechanisms that can trigger or stop such phenomenon, CSD is commonly accepted as a correlate of migraine visual aura. In this paper, we introduce a multiscale PDE-ODE model that couples the propagation of the depolarization wave associated to CSD with a detailed electrophysiological model for the neuronal activity to capture both macroscopic and microscopic dynamics.

No abstract

Application of a solution of 1-glutamine, 75 mM, to the pia-arachnoid surface of the dorsolateral neocortex of rabbits under dial-urethane anaesthesia was found to reversibly render the tissue insusceptible to spreading depression. It is suggested that this amide may play a part in the opposition normally offered by the tissue to undergo spreading depression. Some evidence is adduced which seems to support this suggestion.

No abstract