1951
DOI: 10.1016/0013-4694(51)90079-x
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The slow voltage variation of cortical spreading depression of activity

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Cited by 125 publications
(55 citation statements)
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“…In the normal brain spreading de pression is a fully reversible process, and the ion gradients are reestablished within 1-2 min (Hansen and Lauritzen, 1985). The waves of spreading de pression propagate preferentially in the upper cor tical layers (Leao, 1951). They are associated with increased glucose utilization that rises before the ion shifts between extra-and intracellular space (Shinohara et aI., 1979;Gjedde et aI., 1981).…”
Section: Discussionmentioning
confidence: 99%
“…In the normal brain spreading de pression is a fully reversible process, and the ion gradients are reestablished within 1-2 min (Hansen and Lauritzen, 1985). The waves of spreading de pression propagate preferentially in the upper cor tical layers (Leao, 1951). They are associated with increased glucose utilization that rises before the ion shifts between extra-and intracellular space (Shinohara et aI., 1979;Gjedde et aI., 1981).…”
Section: Discussionmentioning
confidence: 99%
“…Potas sium transients are related to the phenomenon of spreading depression. Spreading depression is as sociated with increased glucose consumption (Shinohara et aI., 1979;Gjedde et aI., 1981) and spreads preferentially in the upper cortical layers (Leao, 1951). In the marginally perfused borders of focal ischemia, failure of potassium clearance may prolong the otherwise transient elevations of the extracellular potassium.…”
Section: Discussionmentioning
confidence: 99%
“…12,31 The perfusion changes may not be the inciting event; rather, the perfusion abnormality may be the response of the autoregulatory mechanisms to underlying neuronal depression. [5][6][7][8][9][10]12,13,29,[31][32][33] This concept is supported by case reports of persistent hyperperfusion despite resolution of headache with abortive therapy. 3,11 Although the exact cause of a migraine has yet to be completely defined, migraines are clinically classified on the basis of the presence or absence of aura phenomenon.…”
Section: 28mentioning
confidence: 99%