Propagation of Spreading Cortical Depression

Leäo, A. A. P.; Morison, Robert S.

doi:10.1097/00005053-194511000-00029

Cited by 54 publications

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“…This knowledge allowed to better understanding the pathophysiology of several acute brain disorders, offering references box. Leão's seminal papers on spreading depression 5,6,7,8 .…”

Section: Resultsmentioning

confidence: 99%

“…In sequence he published another paper, in the same year, with focus on the vasodilatation accompanying SD 6 . Before leaving back to Brazil, he submitted, together with Robert S. Morison, the "Propagation of spreading cortical depression", published in 1945 7 . Later, his first international paper developed in his Brazilian laboratory (1947) appeared 8 .…”

Section: The Discovery Of the "Spreading Depression"mentioning

confidence: 99%

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Aristides Leão: a birth centennial homage with comments on his spreading depression

Engelhardt

Gomes

2015

Arq. Neuro-Psiquiatr.

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The year of 2014 is the birth centenary of Aristides Azevedo Pacheco Leão (1914-1993), and also marks seventy years of the publication of his discovery of the novel electrophysiological phenomenon, named by him “spreading depression” (SD), soon designated “Leão’s wave” or “Leão’s spreading depression”. This was a remarkable scientific milestone, and the author must be celebrated for this achievement, as the studies he triggered proceeded worldwide, with new concepts, as spreading depolarization, until the present days. Robust experimental and clinical evidence emerged to suggest that these and related electrophysiological phenomena are involved in the mechanisms of migraine aura, acute cerebrovascular diseases, traumatic brain injury, transient global amnesia, epileptic seizures, and their pathophysiological characteristics come to offer new therapeutic perspectives. He was a remarkable and complex personality, and the authors remit the readers to a paper where his personal life is contemplated.

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“…This knowledge allowed to better understanding the pathophysiology of several acute brain disorders, offering references box. Leão's seminal papers on spreading depression 5,6,7,8 .…”

Section: Resultsmentioning

confidence: 99%

Section: The Discovery Of the "Spreading Depression"mentioning

confidence: 99%

Aristides Leão: a birth centennial homage with comments on his spreading depression

Engelhardt

Gomes

2015

Arq. Neuro-Psiquiatr.

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“…The analogies between the timing of CSD spreading and that of the progressively expanding visual aura prompted Leao, who firstly described this phenomenon in 1944 [1][2][3], to raise the hypothesis that CSD could be the neurophysiologic correlate of the migrainous aura. Despite the conspicuous research efforts, the first strong evidence of a causative relationship between CSD and MA only arrived in 1981 [4].…”

Section: Cortical Spreading Depression and Migrainementioning

confidence: 99%

Cortical spreading depression and central pain networks in trigeminal nuclei modulation: time for an integrated migraine pathogenesis perspective

et al. 2013

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The role of the cortical spreading depression (CSD)-dependent trigeminovascular activation in migraine etiopathogenesis, long considered paradigmatic, has remained substantially unproven in humans. The parallel advancement of functional neuroimaging techniques promoted the extensive exploration of the brain networks involved in pain processing in search of a possible central migraine generator. However, despite initial enthusiasms, it has not been possible to clarify whether the functional central ''markers'' of pain observed in primary headaches could be considered as causative or just the neural correlates of the ongoing pain. Nonetheless, our knowledge on the complex interactions between CSD, neurogenic inflammation, peripheral trigeminovascular input, central cortico-trigeminal nuclei direct modulation and pain processing and limbic system networks has enormously grown, allowing the reconceptualisation of migraine from a neurovascular to a pure neurolimbic pain disorder, therefore relocating it in the much broader frame of the brain and whole organism homeostatic control. In this work, the available evidences currently supporting the relevance of CSD, of peripheral trigeminovascular input and of direct cortico-trigeminal nuclei modulation in migraine pathogenesis are reviewed in the light of a possible integrated migraine etiopathogenetic perspective.

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“…Este fenômeno foi denominado "depressão alastrante", ou "spreading depression of Leão". Como a velocidade de propagação da DA era semelhante à velocidade de propagação do fenômeno cortical que Lashley observara, Leão sugeriria posteriormente que a DA poderia estar relacionada à fisiopatologia da enxaqueca 40 .…”

Section: Enxaqueca E Depressão Alastranteunclassified

Fisiopatologia da enxaqueca

Vincent

1998

Arq. Neuro-Psiquiatr.

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RESUMO -A fisiopatologia da enxaqueca ainda não foi completamente elucidada. As principais estruturas envolvidas parecem ser o sistema nervoso central (córtex e tronco cerebral), o sistema trigeminovascular e os vasos correspondentes, outras fibras autonômicas que inervam estes vasos, e os vários agentes vasoativos locais, como a SP, CGRP, NO, VIP, NPY, ACh, NA, NKA, entre outros. A depressão alastrante é o fenômeno neurológico que provavelmente justifica achados experimenais e clínicos na enxaqueca. Ela tem velocidade de propagação semelhante à aura, ativa o núcleo espinhal do trigêmeo e está relacionada à liberação de CGRP e NO. Alterações circulatórias detectadas por métodos complementares reforçam o papel da depressão alastrante. A identificação de anormalidades em pelo menos três loci (cromossomas 19 e 1) na enxaqueca hemiplégica familiar ocorreu recentemente. Elas estão relacionadas a anormalidades nos canais de cálcio voltagem dependentes tipo P/Q, específicos do sistema nervoso central, que regulam a liberação de vários neurotransmissores, incluindo possivelmente a serotonina. A exemplo de outras anormalidades neurológicas paroxísticas que resultam da hiperexcitabilidade da membrana plasmática, é possível que a enxaqueca ocorra devido a uma desordem de canais iônicos. PALAVRAS-CHAVE: enxaqueca, fisiopatologia. Migraine pathophysiologyABSTRACT -The pathophysiology of migraine is not yet fully understood. The most important structures involved seem to be the central nervous system (cortex and brain stem), the trigeminovascular system and related cranial arteries, other autonomic fibres innervating such vessels, and various local vasoactive agents, including SP, CGRP, NO, VIP, NPY, ACh, NA, NKA, among others. The spreading depression phenomenon may explain clinical as well experimental findings in migraine. Its propagation velocity mirrors what is found in clinical aura, it may activate the spinal trigeminal nucleus and may induce CGRP and NO release. Circulatory changes detected with various imaging procedures during migraine also support the pathophysiological role of spreading depression. Three abnormal loci (chromosomes 1 and 19) have been recently found in familial hemiplegic migraine. This produces abnormalities in the voltage-dependent P/Q Ca channel, specific for the central nervous system, which regulates the release of various neurotransmitters, probably including serotonin. It is possible that a channelopathy underlies the pathophysiology of migraine, as in other paroxysmal neurological disorders secondary to membrane hyperexcitability.KEY WORDS: migraine, pathophysiology.As cefaléias têm aumentado em importância quando comparadas aos grandes temas neurológicos. Sua prevalência elevada determina consequências significativas para bem-estar do indivíduo e para a produtividade de empresas, comunidades e nações. Não obstante, seu mecanismo fisiopatológico ainda não é completamente conhecido.Muitas foram as hipóteses, mecanismos e causas relacionadas às enxaquecas, tais como alimentos, alergias, vasoe...

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Propagation of Spreading Cortical Depression

Cited by 54 publications

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Aristides Leão: a birth centennial homage with comments on his spreading depression

Aristides Leão: a birth centennial homage with comments on his spreading depression

Cortical spreading depression and central pain networks in trigeminal nuclei modulation: time for an integrated migraine pathogenesis perspective

Fisiopatologia da enxaqueca

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