A methodological basis for providing chemical safety for population is obtained via fixing safe concentrations of hazardous substances, including those in ambient air, as it allows absence of unacceptable risks for people’s life and health. In the Russian Federation average daily maximum permissible concentrations (MPC av.d.) are applied to prevent chronic effects on human health produced by hazardous substances that are present in ambient air. But in world practice it is conventional to apply average annual concentrations when assessing chronic exposure to hazardous substances as it allows applying existing acceptable health risks as assessment criteria. We propose an algorithm for substantiating average annual MPC of chemicals in ambient air as per health risks criteria; the algorithm is harmonized with international approaches and takes into accounts research results taken from previous research works that have been published in relevant scientific sources. The algorithm also involves accomplishing toxicological and/or epidemiologic examinations solely aimed at obtaining missing data. The proposed algorithm envisages selecting starting points for substantiating a hygienic standard and uncertaintyfactors. Proposed methodical approaches have a distinctive feature that is verification of obtained standards as per acceptable (permissible) carcinogenic risk criteria and assessment of safety under exposure equal to MPC av.an. during the whole life span. Development and implementation of average annual maximum permissible concentrations of hazardous substances in ambient air will promote harmonization of the domestic regulatory base with hygienic standards and norms accepted in world practice.
Introduction. The analysis of the sanitary and epidemiological situation in the Russian Federation indicates problems in the field of drinking water safety, caused, among other things, by chemical contamination. Due to the wide variety of pollutants, it is necessary to determine the procedure for identifying priority chemical pollutions from the water from centralized supply systems, using health risk criteria. Materials and methods. The analysis of relevant scientific literature and regulatory and methodological documents formed the basis for developing criteria for determining priority chemical pollutants contained in the water from centralized supply systems. A sampling of drinking water was carried out at the start point (water intake) and the endpoint of the distribution network (water tap). The selected water samples were examined using the chromatography-mass spectrometry method. Results. An algorithm for determining the priority chemicals in the water of centralized water supply systems according to the potential hazard and health risk criteria has been developed. Approaches to the identification of possible sources of chemical water pollutants from centralized supply systems were established. According to the results of testing, it was found that three of the 16 chemical water components are potentially dangerous: 1,1,2,2-tetrachloroethane, pentadecane, and lilial. The presence of pentadecane comes from a water source. Still, it should have eliminated water treatment. The presence of 1,1,2,2-tetrachloroethane and lilial is most likely due to water treatment and water transportation processes through the water supply systems. Conclusion. There are six criteria for determining priority chemical pollutions from the water from centralized supply systems based on hygiene standards compliance, an impact of the chemicals on the environment and the human health, the presence of harmful effects for humans and/or animals, implementation of possible mechanisms for the development of human health disorders and the acceptability of the risk level were proposed. There were identified three priority pollutants in the water from centralized supply systems that can be recommended for further monitoring.
Results of ambient air manganese hygienic standard development using health risk assessment approaches harmonized with international ones are presented. According to health risk level evolutionary modeling results as annual average ambient air manganese standard 0.00005 mg/m 3 was offered, as relevant critical effects-hypersensitivity reactions.
A methodological basis for providing chemical safety for population is obtained via fixing safe concentrations of hazardous substances, including those in ambient air, as it allows absence of unacceptable risks for people’s life and health. In the Russian Federation average daily maximum permissible concentrations (MPC av.d.) are applied to prevent chronic effects on human health produced by hazardous substances that are present in ambient air. But in world practice it is conventional to apply average annual concentrations when assessing chronic exposure to hazardous substances as it allows applying existing acceptable health risks as assessment criteria. We propose an algorithm for substantiating average annual MPC of chemicals in ambient air as per health risks criteria; the algorithm is harmonized with international approaches and takes into accounts research results taken from previous research works that have been published in relevant scientific sources. The algorithm also involves accomplishing toxicological and/or epidemiologic examinations solely aimed at obtaining missing data. The proposed algorithm envisages selecting starting points for substantiating a hygienic standard and uncertaintyfactors. Proposed methodical approaches have a distinctive feature that is verification of obtained standards as per acceptable (permissible) carcinogenic risk criteria and assessment of safety under exposure equal to MPC av.an. during the whole life span. Development and implementation of average annual maximum permissible concentrations of hazardous substances in ambient air will promote harmonization of the domestic regulatory base with hygienic standards and norms accepted in world practice.
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