Аналіз Оперативного Лікування Осіб Літнього Та Старечого Віку З Переломами Проксимального Відділу Стегнової Кістки Методом Накісткового Остеосинтезу Пластиною

Kalchenko, Andrii; Babalyan, Vladimir; Khvysyuk, Alexander; Gurbanova, T. S.; Cherepov, V.V.

doi:10.22141/1608-1706.3.18.2017.105365

Cited by 4 publications

(2 citation statements)

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“…Загальновизнаними та високоефективними методами лікування ППВСК є хірургічні (остеосинтез або ендопротезування). Проте віддалені результати після накісткового остеосинтезу в більшості випадків класифікують як незадовільні (до 87,5 %) [6][7]. При цьому визнано, що метод ендопротезування кульшового суглоба є ефективнішим і сприяє досягненню функціонального відновлення на ранніх термінах лікування [7].…”

Section: вступunclassified

Immune features of the bone remodelling after the hip arthroplasty in elderly and senile patients with proximal femur fractures

Babalyan¹,

S²,

Khvysyuk³

2020

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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Section: вступunclassified

Immune features of the bone remodelling after the hip arthroplasty in elderly and senile patients with proximal femur fractures

Babalyan¹,

S²,

Khvysyuk³

2020

ORTHOPAEDICS, TRAUMATOLOGY and PROSTHETICS

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“…Osteosynthesis and endoprosthetics are generally accepted methods of such fractures surgical treatment. However, long-term results after plate osteosynthesis are often unsatisfactory (up to 87.5% of cases) [1]. The method of hip arthroplasty is more effective and contributes to the achievement of functional recovery in the early stages.…”

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confidence: 99%

Bone remodeling features in elderly and senile patients with the proximal femur fractures after hip replacement

et al. 2020

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The aim of this study is to identify the dependence of the result of surgical treatment of patients of elderly and senile age with fractures of the proximal femur on the characteristics of the response cytokine-mediated regulatory response to trauma and surgery. Materials and methods: In 74 patients after hip arthroplasty, serum levels of bone metabolism markers were determined using enzyme-linked immunosorbent assay. Patients were divided into 2 groups depending on the results of treatment. Results: It was found that compared with group 2 (treatment outcome is worse) in group 1 (treatment outcome is better) there was a greater number of correlations. In group 1, correlations were found between OPG and RANKL (r = 0.88; p = 0.000), OPG and OPG/RANKL (r = 0.44; p = 0.006), TGF-β1 and OPG/RANKL (r = 0.66; p = 0.000) , IL-6 and OPG (r = 0.67; p = 0.000), IL-6 and RANKL (r = 0.53; p = 0.001), IL-6 and OPG/RANKL (r = 0.39; p = 0.016). In group 2, only between OPG and OPG/RANKL (r = 0.72; p = 0.000), RANKL and OPG/RANKL (r = −0.53; p = 0.0007). In patients of group 2, there was a decrease in the level of OPG relative to the control and a less significant increase in TGF-β1 and IL-6 relative to group 1. Conclusion: The prognosis of the results of treatment of patients with proximal femur fractures is largely determined by the nature of the adaptive response to injury and the implant, the synchronism of the mechanism of stress remodeling of the bone. A less favorable prognosis after arthroplasty is associated with exacerbation of the initial metabolic disorders in the bone tissue due to severe cytokine-mediated dysfunction of the regulatory pathways.

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The Interdependence of Medical-Epidemiological and Anamnestic Characteristics of Patients with Proximal Femur Fractures

Hurbanova¹

2020

Ukr. ž. med. bìol. sportu

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Many studies have confirmed that the incidence of fractures of the proximal femur increases significantly with age and doubles every ten years after the age of 50. It was found out that these patients average age increases by one year every five years, and more than 50.00% with damage to this location are over 60 years old. The purpose of the study was to determine the regional correlation features of the interdependence of medical-epidemiological and anamnestic characteristics of patients with proximal femur fractures. Material and methods. To achieve the main goal, we conducted a retrospective study of patients with such fractures according to seven medical institutions in Kharkiv. Results and discussion. When studying the correlation levels of interdependence between various medical-epidemiological and anamnestic characteristics of the examined patients we stated that the female sex correlated with all age periods, which confirmed the predominance of females among the examined all age categories: the sex of patients determined reliable (average <0.001); forces correlation with age characteristics: k = 0.349; the possible influence of gender characteristics on the choice of treatment tactics was stated reliable (p = 0.003); the inverse weak correlation with the type of treatment was recorded: k = -0.041; the possibilities of the influence of age characteristics on comorbid burden; the presence of concomitant pathology and the choice of treatment tactics were clarified: it was determined that the age of the examined patients was significantly (p = 0.014) inversely weakly correlated with the presence of comorbidities and comorbid burden (respectively k = -0.050 (p < 0.001) and k = -0.047 (p <0.001)) and the type of treatment: k = -0.193 (p <0.001); possibilities of influence of more significant comorbid burden on indicators of levels of functional condition and increase in duration of terms of receipt to traumatological departments and reception of qualitative medical care were established: reliable (p <0.001) direct weak correlation was received between indicators of age of trauma and presence of concomitant diseases k = 0.081), comorbid load (k = 0.087) and functional state according to the ASA classification (k = 0.084); determined the stable effect of the existing concomitant pathology and comorbid burden at the level of functional status and its possible impact on using conservative treatment: the presence of comorbidities correlated strongly with comorbid burden (k = 0.989, p <0.001); functional state was evaluated according to ASA classification k = 0.985, p <0.001) and directly weak with the type of treatment (k = 0.228, p <0.001); a direct strong correlation was found between the comorbid burden and functional status according to the ASA classification and the type of treatment performed (respectively k = 0.979 and k = 0.226; p <0.001); the possible influence of low functional state on the choice of treatment tactics was stated: it was proved that the functional state significantly weakly correlated with the type of treatment: k = 0.229, p <0.001. Further research is planned to establish the possibility of predicting the use of treatment tactics and the development of reliable prognostic statistical models of the dependence of the results of different treatment methods on the medical-epidemiological and anamnestic characteristics of patients

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Аналіз Оперативного Лікування Осіб Літнього Та Старечого Віку З Переломами Проксимального Відділу Стегнової Кістки Методом Накісткового Остеосинтезу Пластиною

Cited by 4 publications

References 0 publications

Immune features of the bone remodelling after the hip arthroplasty in elderly and senile patients with proximal femur fractures

Immune features of the bone remodelling after the hip arthroplasty in elderly and senile patients with proximal femur fractures

Bone remodeling features in elderly and senile patients with the proximal femur fractures after hip replacement

The Interdependence of Medical-Epidemiological and Anamnestic Characteristics of Patients with Proximal Femur Fractures

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