γ T cells are decreased in the blood of children with <i>Bordetella pertussis</i> infection

Bertotto, A; Benedictis, F. de; Vagliasindi, C; Radicioni, Maurizio; Spinozzi, Fabrizio; Fabietti, Gm; Castellucci, G; Ferraro, Luigi; Cozzali, Rita; Niccoli, Antonio; Vaccaro, R

doi:10.1111/j.1651-2227.1997.tb08844.x

Cited by 8 publications

(4 citation statements)

References 9 publications

(1 reference statement)

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“…The mechanism of this decrease in circulating γδ T-cell levels remains unclear; however, a number of recent reports have described a decrease in circulating γδ T cells in patients with Bordetella pertussis infection or bronchial asthma, [16][17][18] which was attributed to an enhanced influx of these cells into the site of inflammation, namely, the bronchial mucosa. 18 Diacovo et al reported that γδ T cells are more efficient than α T cells in binding to P-selectin in blood flow, and human T lymphocyte interactions with Pselectin may be more important in lymphocyte extravasation than previously thought.…”

Section: Discussionmentioning

confidence: 96%

Changes in T-cell receptor subsets after cardiac surgery in children

et al. 2000

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T cells are divided into two subsets, alphabeta and gammadelta, according to the T-cell receptor (TCR) expressed. Recent findings indicate that gammadelta T cells serve as the first defense against microbial pathogens, and represent a link between innate and acquired immunity. We conducted a study to investigate the changes in circulating TCR subsets after cardiac surgery in children. Blood samples from 24 children who underwent cardiac surgery with cardiopulmonary bypass (CPB) were collected serially to analyze TCR subsets by flow cytometry. The alphabeta T cells reached a nadir on postoperative day (POD) 1, but recovered to pre-CPB levels on POD 3. On the other hand, the gammadelta T cells decreased after CPB and did not recover to pre-CPB levels even after POD 7. The alphabeta/gammadelta T-cell ratio was increased after POD 3. In children, gammadelta T cells recover more slowly than alphabeta T cells after cardiac surgery. These changes in TCR subsets may contribute to postoperative immunosuppression.

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Section: Discussionmentioning

confidence: 96%

Changes in T-cell receptor subsets after cardiac surgery in children

et al. 2000

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“…Although little is known about the importance of ␥␦ ϩ T lymphocytes during B. pertussis infection, a role for these cells in the response of infected children has previously been suggested via the migration of circulating ␥␦ ϩ T cells to the airways (9). Moreover, using a murine aerosol challenge model, Zachariadis and coworkers demonstrated that the absence of ␥␦ ϩ T cells could influence the subsequent adaptive immune response to B. pertussis antigens, as evidenced by a shift from a Th1-type response to a Th2-type response against filamentous hemagglutinin in TCR ␥␦ Ϫ/Ϫ mice (48).…”

Section: Discussionmentioning

confidence: 99%

Immunogenicity of a Whole-Cell Pertussis Vaccine with Low Lipopolysaccharide Content in Infants

Zorzeto

Higashi

Silva

et al. 2009

Clin Vaccine Immunol

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Gamma interferon, tumor necrosis factor alpha, interleukin-4 (IL-4), and IL-10 levels in supernatants and serum anti-PT IgG levels were determined using enzyme-linked immunosorbent assay (ELISA). The net percentage of CD3؉ blasts in cultures with B. pertussis in the group vaccinated with wP was higher than that in the group vaccinated with the wP low vaccine (medians of 6.2% for the wP vaccine and 3.9% for the wP low vaccine; P ‫؍‬ 0.029). The frequencies of proliferating CD4 ؉ , CD8 ؉ , and ␥␦ ؉ cells, cytokine concentrations in supernatants, and the geometric mean titers of anti-PT IgG were similar for the two vaccination groups. There was a significant difference between the T-cell subpopulations for B. pertussis and PHA cultures, with a higher percentage of ␥␦ ؉ cells in the B. pertussis cultures (P < 0.001). The overall data did suggest that wP vaccination resulted in modestly better specific CD3 ؉ cell proliferation, and ␥␦ ؉ cell expansions were similar with the two vaccines.

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“…Gamma-delta T cells exert protective functions in barrier surveillance and first-line defense in lungs after influenza infection ( Wang et al, 2021 ). Gamma-delta T cells were observed to be decreased in the blood of patients with asthma or Bordetella pertussis infection ( Bertotto et al, 1997 ; Krejsek et al, 1998 ). Austin et al revealed that there is a significant increase in the number of effector memory T cells in the peripheral blood of patients with IPAH versus controls and a prominent increase in the number of CD8 T cells in the lungs of patients with IPAH ( Austin et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Identification of Crucial Hub Genes and Differential T Cell Infiltration in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics Strategies

Yang

Wang

Lin

et al. 2022

Front. Mol. Biosci.

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Background: Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease. Growing evidence indicated that IPAH is a chronic immune disease. This study explored the molecular mechanisms and T cell infiltration of IPAH using integrated bioinformatics methods.Methods: Gene expression profiles of dataset GSE113439 were downloaded from the Gene Expression Omnibus and analyzed using R. Protein-protein interaction (PPI) network and gene set enrichment analysis (GSEA) were established by NetworkAnalyst. Gene Ontology enrichment analysis was performed using ClueGO. Transcription factors of differentially expressed genes (DEGs) were estimated using iRegulon. Transcription factors and selected hub genes were verified by real-time polymerase chain reaction (qPCR) in the lung tissues of rats with pulmonary artery hypertension. The least absolute shrinkage and selection operator regression model and the area under the receiver operating characteristic curve (AUC) were applied jointly to identify the crucial hub genes. Moreover, immune infiltration in IPAH was calculated using ImmuCellAI, and the correlation between key hub genes and immune cells was analyzed using R.Results: A total of 512 DEGs were screened, and ten hub genes and three transcription factors were filtered by the DEG PPI network. The DEGs were mainly enriched in mitotic nuclear division, chromosome organization, and nucleocytoplasmic transport. The ten hub genes and three transcription factors were confirmed by qPCR. Moreover, MAPK6 was identified as the most potent biomarker with an AUC of 100%, and ImmuCellAI immune infiltration analysis showed that a higher proportion of CD4-naive T cells and central memory T cells (Tcm) was apparent in the IPAH group, whereas the proportions of cytotoxic T cells (Tc), exhausted T cells (Tex), type 17 T helper cells, effector memory T cells, natural killer T cells (NKT), natural killer cells, gamma-delta T cells, and CD8 T cells were lower. Finally, MAPK6 was positively correlated with Tex and Tcm, and negatively correlated with Tc and NKT.Conclusion:MAPK6 was identified as a crucial hub gene to discriminate IPAH from the normal group. Dysregulated immune reactions were identified in the lung tissue of patients with IPAH.

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γ T cells are decreased in the blood of children with Bordetella pertussis infection

Cited by 8 publications

References 9 publications

Changes in T-cell receptor subsets after cardiac surgery in children

Changes in T-cell receptor subsets after cardiac surgery in children

Immunogenicity of a Whole-Cell Pertussis Vaccine with Low Lipopolysaccharide Content in Infants

Identification of Crucial Hub Genes and Differential T Cell Infiltration in Idiopathic Pulmonary Arterial Hypertension Using Bioinformatics Strategies

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