γ-Fe2O3 nanoflowers as efficient magnetic hyperthermia and photothermal agent

Shaw, S.K.; Kailashiya, Jyotsna; Gangwar, Anshu; Alla, S.K.; Gupta, Santosh K.; Prajapat, C.L.; Meena, Sher Singh; Dash, Debabrata; Maiti, Pralay; Prasad, N.K.

doi:10.1016/j.apsusc.2021.150025

Cited by 44 publications

(23 citation statements)

References 66 publications

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“…For all samples, the decay at 525 (Figure 5b) is modeled by a biexponential function (eq S22) suggesting two different modes of de-excitation which are heterogeneously distributed. 14 Such results are consistent with the previously evidenced presence of both F and F + centers. Mean values of τ 1 = 29 ± 2 μs and τ 2 = 4.6 ± 0.5 μs with relative proportions (eq S23) 80 of 64 ± 5% and 36 ± 5% are found.…”

Section: Resultssupporting

confidence: 91%

“…12 Because of a lower surface/volume ratio, NFs also present lower spin surface disorders when compared to single-core structures. 13 More recently, magnetic NFs have been proved to be promising materials for photothermal therapy (PTT) thanks to their absorption in the first 14 (around 808 nm for maghemite) and second 15 (around 1064 nm for magnetite) infra-red biological windows. However, how the fine structure features of NFs at the nanoscale govern their properties and their collective function in MHT and PT still needs to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

et al. 2021

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Magnetite and maghemite multi-core nanoflowers (NFs) synthesized using the modified polyol-mediated routes are to date among the most effective nano-heaters in magnetic hyperthermia (MHT). Recently, magnetite NFs have also shown high photothermal (PT) performances in the most desired second near infra-red (NIR-II) biological window making them attractive in the field of nanoparticle-activated thermal therapies. However, what makes magnetic NFs efficient heating agents in both modalities still remain an open question. In this work, we investigate the role of many parameters of the polyol synthesis on the final NFs size, shape, chemical composition, number of cores and crystallinity. These nanofeatures are later correlated to the magnetic, optical and electronic properties of the NFs as well as their collective macroscopic thermal properties in MHT and PT to find relationships between their structure, properties and function. We evidence the critical role of iron(III) and heating ramps on the elaboration of well-defined NFs with high number of multi-cores. While MHT efficiency is found to be proportional to the average number of magnetic cores within the assemblies, the optical responses of the NFs and their collective photothermal properties depend directly on the mean volume of the NFs (as supported by optical cross sections numerical simulations) and strongly on the structural disorder in the NFs, rather than the stoichiometry. The concentration of defects in the nanostructures, evaluated by photoluminescence and Urbach energy (EU), evidences a switch in the optical behavior for a limit value of EU = 0.4 eV where a discontinuous transition from high to poor PT efficiency is also observed. Keywordsmulti-core iron oxides, nanoflowers, magnetic nanoparticles, magnetic hyperthermia, photothermia, nanothermal agents, thermal therapies distributions histograms, powder XRD diffraction data and Rietveld refinements, XANES data, 57 Fe Mössbauer spectra, SQUID, TGA, ZFC/FC measurements and DLS measurements, ILP values, Python codes, Beer-Lambert plots at 1064 nm, Urbach and Tauc plots, MHT and PT measurements, fluorescence emission spectra and additional tables.

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Section: Resultssupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

et al. 2021

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“…The condensed clustering structure refers to the in situ clustering of MIONs during crystal growth, in such a fashion that the individual MIONs adopt the same crystallographic orientation with their neighboring crystals through epitaxial aggregation [ 42 , 47 , 48 ]. This dense packing of MIONs can dramatically enhance the magnetic properties of the synthesized NPs, boosting their performance in magnetic targeting, magnetic hyperthermia, photothermal therapy, and MRI applications [ 46 , 49 , 50 , 51 ]. Such attributes make MIONs of co-CNCs a highly attractive platform for further derivatization with radioisotopes towards combinatorial approaches to tackle cancer and incorporate multimodal imaging techniques to a single theranostic agent.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents

et al. 2022

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Theranostic radioisotope pairs such as Gallium-68 (68Ga) for Positron Emission Tomography (PET) and Lutetium-177 (177Lu) for radioisotopic therapy, in conjunction with nanoparticles (NPs), are an emerging field in the treatment of cancer. The present work aims to demonstrate the ability of condensed colloidal nanocrystal clusters (co-CNCs) comprised of iron oxide nanoparticles, coated with alginic acid (MA) and stabilized by a layer of polyethylene glycol (MAPEG) to be directly radiolabeled with 68Ga and its therapeutic analog 177Lu. 68Ga/177Lu- MA and MAPEG were investigated for their in vitro stability. The biocompatibility of the non-radiolabeled nanoparticles, as well as the cytotoxicity of MA, MAPEG, and [177Lu]Lu-MAPEG were assessed on 4T1 cells. Finally, the ex vivo biodistribution of the 68Ga-labeled NPs as well as [177Lu]Lu-MAPEG was investigated in normal mice. Radiolabeling with both radioisotopes took place via a simple and direct labelling method without further purification. Hemocompatibility was verified for both NPs, while MTT studies demonstrated the non-cytotoxic profile of the nanocarriers and the dose-dependent toxicity for [177Lu]Lu-MAPEG. The radiolabeled nanoparticles mainly accumulated in RES organs. Based on our preliminary results, we conclude that MAPEG could be further investigated as a theranostic agent for PET diagnosis and therapy of cancer.

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“…It was about 10 mm penetration depth with porcine muscle tissues when using 808 nm laser [ 34 – 37 ], indicating that the near-infrared laser employed in photothermal therapy has great constraints for irradiating magnetic IONPs in deep depth tissues [ 38 ]. Compared with PTT, deep penetration problems can be addressed effectively with MHT, but the heating yield per nanoparticle amount of MHT is much inferior to PTT [ 38 – 40 ]. Additionally, MHT requires high frequencies alternating magnetic fields ranging from kilohertz to megahertz [ 41 – 44 ] and appropriate amplitude [ 38 ], which is costly and inconvenient.…”

Section: Introductionmentioning

confidence: 99%

Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects

Mohsin

Zaman

et al. 2022

J Nanobiotechnol

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Background Magnetic materials mediated by mechanical forces to combat cancer cells are currently attracting attention. Firstly, the magnetic force penetrates deeper into tissues than the NIR laser alone to destroy tumours. Secondly, the synergistic effect of nano-magnetic-material characteristics results in a viable option for the targeted killing of cancer cells. Therefore, mechanical force (MF) produced by magnetic nanomaterials under low frequency dynamic magnetic field combined with laser technology is the most effective, safe and efficient tool for killing cancer cells and tumour growth. Results In this study, we synthesized novel urchin-like hollow magnetic microspheres (UHMMs) composed of superparamagnetic Fe3O4. We demonstrated the excellent performance of UHMMs for killing laryngocarcinoma cancer cells through mechanical force and photothermal effects under a vibrating magnetic field and near-infrared laser, respectively. The killing efficiency was further improved after loading the synthesised UHMMs with Chlorin e6 relative to unloaded UHMMs. Additionally, in animal experiments, laryngocarcinoma solid tumour growth was effectively inhibited by UHMMs@Ce6 through magneto-mechanic force, photothermal and photodynamic therapy. Conclusions The biocompatibility and high efficiency of multimodal integrated therapy with the UHMMs prepared in this work provide new insights for developing novel nano therapy and drug loading platforms for tumour treatment. In vivo experiments further demonstrated that UHMMs/Ce6 are excellent tools for strongly inhibiting tumour growth through the above-mentioned characteristic effects. Graphical Abstract

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γ-Fe2O3 nanoflowers as efficient magnetic hyperthermia and photothermal agent

Cited by 44 publications

References 66 publications

Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

Preliminary Evaluation of Iron Oxide Nanoparticles Radiolabeled with 68Ga and 177Lu as Potential Theranostic Agents

Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects

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