Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

Bertuit, Enzo; Benassai, Emilia; Mériguet, Guillaume; Grenèche, Jean‐Marc; Baptiste, Benoı̂t; Neveu, Sophie; Wilhelm, Claire; Abou‐Hassan, Ali

doi:10.1021/acsnano.1c06212

Cited by 45 publications

(90 citation statements)

References 81 publications

(144 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…First of all, light with partially transparent tissues would reduce the main drawback of magnetic field-induced hyperthermia, i.e., low tissue penetration [ 73 ]. Both photothermia and magnetic hyperthermia have been intensively studied as potential cancer treatments [ 75 , 76 , 77 ].…”

Section: Hyperthermiamentioning

confidence: 99%

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

et al. 2022

View full text Add to dashboard Cite

Until now, strategies used to treat cancer are imperfect, and this generates the need to search for better and safer solutions. The biggest issue is the lack of selective interaction with neoplastic cells, which is associated with occurrence of side effects and significantly reduces the effectiveness of therapies. The use of nanoparticles in cancer can counteract these problems. One of the most promising nanoparticles is magnetite. Implementation of this nanoparticle can improve various treatment methods such as hyperthermia, targeted drug delivery, cancer genotherapy, and protein therapy. In the first case, its feature makes magnetite useful in magnetic hyperthermia. Interaction of magnetite with the altered magnetic field generates heat. This process results in raised temperature only in a desired part of a patient body. In other therapies, magnetite-based nanoparticles could serve as a carrier for various types of therapeutic load. The magnetic field would direct the drug-related magnetite nanoparticles to the pathological site. Therefore, this material can be used in protein and gene therapy or drug delivery. Since the magnetite nanoparticle can be used in various types of cancer treatment, they are extensively studied. Herein, we summarize the latest finding on the applicability of the magnetite nanoparticles, also addressing the most critical problems faced by smart nanomedicine in oncological therapies.

show abstract

Section: Hyperthermiamentioning

confidence: 99%

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

et al. 2022

View full text Add to dashboard Cite

show abstract

“…We recorded zero-field cooled (ZFC) and field cooled (FC) magnetization curves, as well as magnetic hysteresis loops, to characterize the magnetic response from the iron oxide cores. 34 The Fe 2 O 3 composition of the cores was first confirmed by electron energy loss spectroscopy (EELS), using IOAuNS bII as a representative sample (Figure S12A,B). To test for potential further oxidation over time, which would affect the magnetic properties, hysteresis loops were recorded for both freshly prepared and aged (6 months postsynthesis) IONPs.…”

Section: Synthesis Of Magnetic−plasmonic Nanoparticlesmentioning

confidence: 99%

Hybrid Magnetic–Plasmonic Nanoparticle Probes for Multimodal Bioimaging

et al. 2022

View full text Add to dashboard Cite

Multimodal contrast agents, which take advantage of different imaging modalities, have emerged as an interesting approach to overcome the technical limitations of individual techniques. We developed hybrid nanoparticles comprising an iron oxide core and an outer gold spiky layer, stabilized by a biocompatible polymeric shell. The combined magnetic and optical properties of the different components provide the required functionalities for magnetic resonance imaging (MRI), surface-enhanced Raman scattering (SERS), and fluorescence imaging. The fabrication of such hybrid nanoprobes comprised the adsorption of small gold nanoparticles onto premade iron oxide cores, followed by controlled growth of spiky gold shells. The gold layer thickness and branching degree (tip sharpness) can be controlled by modifying both the density of Au nanoparticle seeds on the iron oxide cores and the subsequent nanostar growth conditions. We additionally demonstrated the performance of these hybrid multifunctional nanoparticles as multimodal contrast agents for correlative imaging of in vitro cell models and ex vivo tissues.

show abstract

“…Unlike their metallic counterparts, iron-oxide (Fe

and

) NPs have been approved by the FDA for clinical magnetic thermotherapy [ 16 , 17 ]. Their intrinsic ability of generate heat within a short time under NIR irradiation as well as drive high barrier reactions makes them attractive for N-PTT [ 13 , 18 , 19 , 20 ]. Recently, these ceramic NPs have been demonstrated in single (photothermal only) or multimodal (simultaneous photothermal & magnetic) applications.…”

Section: Introductionmentioning

confidence: 99%

Photothermally-Heated Superparamagnetic Polymeric Nanocomposite Implants for Interstitial Thermotherapy

et al. 2022

View full text Add to dashboard Cite

Photothermally-heated polymer-based superparamagnetic nanocomposite (SNC) implants have the potential to overcome limitations of the conventional inductively-heated ferromagnetic metallic alloy implants for interstitial thermotherapy (IT). This paper presents an assessment of a model SNC—poly-dimethylsiloxane (PDMS) and Fe3O4 nanoparticles (MNP)—implant for IT. First, we performed structural and optical characterization of the commercially purchased MNPs, which were added to the PDMS to prepare the SNCs (MNP weight fraction =10 wt.%) that were used to fabricate cubic implants. We studied the structural properties of SNC and characterized the photothermal heating capabilities of the implants in three different media: aqueous solution, cell (in-vitro) suspensions and agarose gel. Our results showed that the spherical MNPs, whose optical absorbance increased with concentration, were uniformly distributed within the SNC with no new bond formed with the PDMS matrix and the SNC implants generated photothermal heat that increased the temperature of deionized water to different levels at different rates, decreased the viability of MDA-MB-231 cells and regulated the lesion size in agarose gel as a function of laser power only, laser power or exposure time and the number of implants, respectively. We discussed the opportunities it offers for the development of a smart and efficient strategy that can enhance the efficacy of conventional interstitial thermotherapy. Collectively, this proof-of-concept study shows the feasibility of a photothermally-heated polymer-based SNC implant technique.

show abstract

Structure–Property–Function Relationships of Iron Oxide Multicore Nanoflowers in Magnetic Hyperthermia and Photothermia

Cited by 45 publications

References 81 publications

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

Hybrid Magnetic–Plasmonic Nanoparticle Probes for Multimodal Bioimaging

Photothermally-Heated Superparamagnetic Polymeric Nanocomposite Implants for Interstitial Thermotherapy

Contact Info

Product

Resources

About