Magnetite Nanoparticles in Magnetic Hyperthermia and Cancer Therapies: Challenges and Perspectives

Abstract

Until now, strategies used to treat cancer are imperfect, and this generates the need to search for better and safer solutions. The biggest issue is the lack of selective interaction with neoplastic cells, which is associated with occurrence of side effects and significantly reduces the effectiveness of therapies. The use of nanoparticles in cancer can counteract these problems. One of the most promising nanoparticles is magnetite. Implementation of this nanoparticle can improve various treatment methods such as hyperthermia, targeted drug delivery, cancer genotherapy, and protein therapy. In the first case, its feature makes magnetite useful in magnetic hyperthermia. Interaction of magnetite with the altered magnetic field generates heat. This process results in raised temperature only in a desired part of a patient body. In other therapies, magnetite-based nanoparticles could serve as a carrier for various types of therapeutic load. The magnetic field would direct the drug-related magnetite nanoparticles to the pathological site. Therefore, this material can be used in protein and gene therapy or drug delivery. Since the magnetite nanoparticle can be used in various types of cancer treatment, they are extensively studied. Herein, we summarize the latest finding on the applicability of the magnetite nanoparticles, also addressing the most critical problems faced by smart nanomedicine in oncological therapies.

pH-Responsible Doxorubicin-Loaded Fe3O4@CaCO3 Nanocomposites for Cancer Treatment

“…MNCs have widespread applications in drug delivery, magnetic field-influenced transport, magnetic resonance imaging, hyperthermia therapy, theranostics, magnetic separation, and biosensor areas [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. NC is a promising tool for external magnetic field target-specific delivery of anticancer agents [ 1 , 21 , 22 , 30 ].…”

A Fast, Reliable Oil-In-Water Microemulsion Procedure for Silica Coating of Ferromagnetic Zn Ferrite Nanoparticles Capable of Inducing Cancer Cell Death In Vitro

“…In the field of novel cancer therapy, magnetic nanoparticles (MNPs) are widely investigated within magnetic hyperthermia (MH) treatment [1][2][3]. The technique exploits the Néel magnetic relaxation, Brownian rotation, and hysteresis losses of MNPs, when subjected to an alternating magnetic field (AFM), to generate sufficient heat for inducing cancer cell death [4][5][6].…”

A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

“…Especially, advances in hybrid magnetic nanostructures research have had a groundbreaking impact on biomedical applications [ 12 ]. Hybrid magnetic nanostructures (MHNs) can be used in magnetic separation, diagnostics, cancer drug delivery, in vivo imaging of cancer, and as contrast agents in MRIs [ 13 , 14 ]. A great deal of effort has been spent on developing ferromagnetic MHNs with controlled parameters [ 15 , 16 , 17 , 18 ].…”