β2-Adrenergic receptor-dependent sexual dimorphism for murine leukocyte migration

Coupade, Catherine de; Brown, Adrienne S.; Dazin, Paul; Levine, Jon D.; Green, Paul G.

doi:10.1016/j.jneuroim.2007.02.010

Cited by 10 publications

(9 citation statements)

References 97 publications

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“…However, a decrease of 1.5 times of the stiffness under Ca 2+ load promotes the intensive use of the membrane reserve by cells during the regulation of their volume in a hypotonic medium. The effects discussed are closely connected with the mechanism of regulation of cell surface stiffness through the elements of cytoskeleton (de Coupade et al 2007;Feske 2007;Insall and Machesky 2009) and generally agree with the results obtained in the present work.…”

Section: Discussionsupporting

confidence: 90%

C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes

et al. 2015

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The influence of aqueous solution of pristine C60 fullerene (C60FAS) on functional activity of lymphocytes from a healthy person was studied for the first time. By means of atomic force microscopy, it was found that C60FAS in a concentration of 0.1 mg/ml increases the stiffness of the lymphocyte membrane by 41% (p < 0.05) and lowers the functional activity of the plasmalemma surface, thereby constraining the use of its membrane material in physiological reactions using a hypotonic model in vitro. However, a cell retains the ability to regulate its volume and demonstrates relative resistance to hypo-osmotic stress. The resistance of lymphocytes in hypo-osmotic medium is facilitated by activation of the nucleus by C60 fullerene particles, which regulates the implementation of two consistent phases of an increase and decrease of cell volume, thereby retaining cell viability. All these indicate the impact of C60 fullerene on the cellular nucleus.

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Section: Discussionsupporting

confidence: 90%

C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes

et al. 2015

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“…1). Next, to determine if NLB induces plasticity in nociceptor function we evaluated the hyperalgesia induced by a well-studied inflammatory mediator, PGE 2 , which produces a markedly prolonged hyperalgesia after adult exposure to stress [30], hyperalgesia that is mediated by a second messenger (PKCε) dependent signaling pathway [17,20,21,44]. In both naive control and NLB rats, PGE 2 (1 μg, into the gastrocnemius muscle)induced mechanical hyperalgesia with a rapid onset.…”

Section: Resultsmentioning

confidence: 99%

“…NLB-treatment produced mechanical hyperalgesia in skeletal muscle and prolongation of inflammatory mediator-induced hyperalgesia (i.e., hyperalgesic priming) [17], as well as hyperalgesic priming in the cutaneous domain, measured in adult rats. While treatment with PKCε antisense in adult NLB-treated rats only slightly reduced ongoing mechanical hyperalgesia in muscle, but not skin, it completely reversed hyperalgesic priming in both muscle and skin, implicating a role of PKCε in this effect of early-life stress.…”

Section: Discussionmentioning

confidence: 99%

Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat

Green

Chen

Álvarez

et al. 2011

Pain

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100

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Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this model, litters are exposed to limited bedding between postnatal days 2 – 9 (neonatal limited bedding, NLB) and controls to standard bedding. In adult NLB-treated rats, mechanical nociceptive threshold in skeletal muscle was ficantly lower (~22%) than in controls. Furthermore, administration of prostaglandin E2 (PGE2) in skin as well as produced markedly prolonged hyperalgesia, an effect prevented by spinal intrathecal injection of oligodeoxynucleotide antisense to protein kinase CΣ (PKCε), a second messenger in nociceptors that has been implicated in the induction and maintenance of chronic pain. In electrophysiological studies, mechanical threshold of muscle nociceptors was reduced by ~31% and conduction velocity significantly increased (~28%). These findings indicate that neonatal stress induces apersistent hyperalgesia and nociceptor sensitization manifest in the adult and that the second messenger PKCε may be a target against which therapies might be directed to treat a chronic pain syndrome that is associated with early-life traumatic stress.

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“…Such sexual dimorphism is common: in the liver, for example, a large number of genes are sex-specific, with STAT5a playing a key role in regulating sex-specific gene expression in the female liver and STAT5b in the male liver29. The beta(2)-adrenergic receptor on male leukocytes appears to contribute to sexual dimorphism in murine leukocyte migration30. In the ear, mice lacking the GABA(A) receptor subunit beta2 display a clear sexual dimorphism in cochlear phenotype31.…”

Section: Discussionmentioning

confidence: 99%

Sexual dimorphism in the effect of GDF‐6 deficiency on murine tendon

Mikic

Rossmeier

Bierwert

2009

Journal Orthopaedic Research

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Three members of the growth/differentiation factor (GDF) subfamily of bone morphogenetic proteins (BMPs), , have demonstrated the potential to augment tendon and ligament repair. To gain further insight into the in vivo role of these molecules, previous studies have characterized intact and healing tendons in mice with functional null mutations in GDF-5 and -7. The primary goal of the present study was to perform a detailed characterization of the intact tendon phenotype in 4-and 16-week-old male and female GDF6À/À mice and their þ/þ littermates. The results demonstrate that GDF6 deficiency was associated with an altered tendon phenotype that persisted into adulthood. Among males, GDF6À/À tail tendon fascicles had significantly less collagen and glycosaminoglycan content, and these compositional differences were associated with compromised material properties. The effect of GDF6 deficiency on tendon was sexually dimorphic, however, for among female GDF6À/À mice, neither differences in tendon composition nor in material properties were detected. The tendon phenotype that was observed in males appeared to be stronger in the tail site than in the Achilles tendon site, where some compositional differences were present, but no material property differences were detected. These data support existing in vitro studies, which suggest a potential role for BMP-13 (the human homologue to GDF-6) in tendon matrix modeling and/or remodeling.

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β2-Adrenergic receptor-dependent sexual dimorphism for murine leukocyte migration

Cited by 10 publications

References 97 publications

C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes

C60 fullerene affects elastic properties and osmoregulation reactions of human lymphocytes

Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat

Sexual dimorphism in the effect of GDF‐6 deficiency on murine tendon

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