β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

Syam, Suvitha; Bustamam, Ahmad; Abdullah, Rasedee; Sukari, Mohamed Aspollah; Hashim, Najihah Mohd; Ghaderian, Mostafa; Rahmani, Mawardi; Mohan, Syam; Abdelwahab, Siddig Ibrahim; Ali, Hapipah Mohd

doi:10.1016/j.jff.2013.10.018

Cited by 35 publications

(24 citation statements)

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“…Similar results were also observed in the following references. β-Mangostin can induce the p53-dependent G 2 /M cell cycle arrest by down-regulating cdc2 and PCNA [37]. Exposure of HEK 293 cells to citrinin induced cell cycle G 2 /M arrest and increased the expression of p53 and p21 proteins [38].…”

Section: Discussionmentioning

confidence: 99%

The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

et al. 2016

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Aflatoxin B1 (AFB1) has potent hepatotoxic, carcinogenic, genotoxic, immunotoxic and other adverse effects in human and animals. The aim of this study was to investigate the molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum of broilers. Broilers, as experimental animals, were fed 0.6 mg/kg AFB1 diet for 3 weeks. Our results showed that AFB1 reduced the jejunal villus height, villus height/crypt ratio and caused G2/M cell cycle arrest. The G2/M cell cycle was accompanied by the increase of ataxia telangiectasia mutated (ATM), p53, Chk2, p21 protein and mRNA expression, and the decrease of Mdm2, cdc25C, cdc2, cyclin B and proliferating cell nuclear antigen protein and mRNA expression. In conclusion, AFB1 blocked G2/M cell cycle by ATM pathway in the jejunum of broilers.

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Section: Discussionmentioning

confidence: 99%

The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

et al. 2016

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“…The purity, physical characteristics, and the structure of BM elucidated in this study was in accordance with literature standards previously documented to obtain from C. arborescens . 8 …”

Section: Methodsmentioning

confidence: 99%

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume

Sidahmed¹,

Hashim²,

Mohan³

et al. 2016

DDDT

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Purposeβ-Mangostin (BM) from Cratoxylum arborescens demonstrated various pharmacological activities such as anticancer and anti-inflammatory. In this study, we aimed to investigate its antiulcer activity against ethanol ulcer model in rats.Materials and methodsBM was isolated from C. arborescens. Gastric acid output, ulcer index, gross evaluation, mucus production, histological evaluation using hematoxylin and eosin and periodic acid–Schiff staining and immunohistochemical localization for heat shock protein 70 (HSP70) and Bax proteins were investigated. Possible involvement of reduced glutathione, lipid peroxidation, prostaglandin E2, antioxidant enzymes, superoxide dismutase and catalase enzymes, radical scavenging, nonprotein sulfhydryl compounds, and anti-Helicobacter pylori were investigated.ResultsBM showed antisecretory activity against the pylorus ligature model. The pretreatment with BM protect gastric mucosa from ethanol damaging effect as seen by the improved gross and histological appearance. BM significantly reduced the ulcer area formation, the submucosal edema, and the leukocytes infiltration compared to the ulcer control. The compound showed intense periodic acid–Schiff staining to the gastric mucus layer and marked amount of alcian blue binding to free gastric mucus. BM significantly increased the gastric homogenate content of prostaglandin E2 glutathione, superoxide dismutase, catalase, and nonprotein sulfhydryl compounds. The compound inhibited the lipid peroxidation revealed by the reduced gastric content of malondialdehyde. Moreover, BM upregulate HSP70 expression and downregulate Bax expression. Furthermore, the compound showed interesting anti-H. pylori activity.ConclusionThus, it could be concluded that BM possesses gastroprotective activity, which could be attributed to the antisecretory, mucus production, antioxidant, HSP70, antiapoptotic, and anti-H. pylori mechanisms.

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“…The AO and PI were intercalating nucleic acid‐specific fluorochromes (Lieca attached with Q‐Floro Software, Solms, Germany), which emitted green and red fluorescence respectively. Of the two, only AO can cross the plasma membrane of viable and early apoptotic cells …”

Section: Methodsmentioning

confidence: 99%

Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering

Al-Namnam

Hwi

Chai

et al. 2016

J of Applied Polymer Sci

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Bone tissue engineering offers high hopes in reconstructing bone defects that result from trauma, infection, tumors, and other conditions. However, there remains a need for novel scaffold materials that can effectively stimulate ossification with appropriate functional properties. Therefore, a novel injectable, biodegradable, and biocompatible scaffold made by incorporating modified poly(caprolactone trifumarate) (PCLTF) with embedded gelatin microparticles (GMPs) as porogen is developed. Specifically, in vitro and in vivo tests were carried out. For the latter, to determine the osteogenic ability of PCLTF-GMPs scaffolds, and to characterize bone-formation, these scaffolds were implanted into critical-sized defects of New Zealand white rabbit craniums. Field Emission Scanning Electron Microscope (FESEM) demonstrated cells of varying shapes attached to the scaffold surface in vitro. The PCLTF-GMPs demonstrated improved biocompatibility in vivo. Polyfluorochrome tracers detected bone growth occurring in the PCLTF-GMPs filled defects. By incorporating PCLTF with GMPs, we have fabricated a promising self-crosslinkable biocompatible and osteoconducive scaffold for bone tissue engineering.

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β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

Cited by 35 publications

References 46 publications

The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume

Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering

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β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

Cited by 35 publications

References 46 publications

The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

The molecular mechanism of G2/M cell cycle arrest induced by AFB1 in the jejunum

Evidence of the gastroprotective and anti-Helicobacter pylori activities of &beta;-mangostin isolated from Cratoxylum arborescens (vahl) blume

Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering

Contact Info

Product

Resources

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Evidence of the gastroprotective and anti-Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume