Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering

Al-Namnam, Nisreen Mohammed; Hwi, Kim Kah; Chai, Wen Lin; Ha, Kien Oon; Siar, Chong Huat; Ngeow, Wei Cheong

doi:10.1002/app.43711

Cited by 5 publications

(4 citation statements)

References 45 publications

(55 reference statements)

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“…These characteristics precisely provide a window of opportunity to regulate the scaffold properties such as biocompatibility, mechanical properties, porosity, biodegradation topography and wettability that directly affect the bone regeneration efficiency [ 91 ]. They can be shaped in different forms or 3D printed into the desired 3D scaffold or can be made available as an injectable form [ 92 ].…”

Section: Polymer-based Bone Substitutesmentioning

confidence: 99%

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

et al. 2021

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Alloplasts are synthetic, inorganic, biocompatible bone substitutes that function as defect fillers to repair skeletal defects. The acceptance of these substitutes by host tissues is determined by the pore diameter and the porosity and inter-connectivity. This narrative review appraises recent developments, characterization, and biological performance of different synthetic materials for bone, periodontal, and dental tissue regeneration. They include calcium phosphate cements and their variants β-tricalcium phosphate (β-TCP) ceramics and biphasic calcium phosphates (hydroxyapatite (HA) and β-TCP ceramics), calcium sulfate, bioactive glasses and polymer-based bone substitutes which include variants of polycaprolactone. In summary, the search for synthetic bone substitutes remains elusive with calcium compounds providing the best synthetic substitute. The combination of calcium sulphate and β-TCP provides improved handling of the materials, dispensing with the need for a traditional membrane in guided bone regeneration. Evidence is supportive of improved angiogenesis at the recipient sites. One such product, (EthOss® Regeneration, Silesden UK) has won numerous awards internationally as a commercial success. Bioglasses and polymers, which have been used as medical devices, are still in the experimental stage for dental application. Polycaprolactone-TCP, one of the products in this category is currently undergoing further randomized clinical trials as a 3D socket preservation filler. These aforementioned products may have vast potential for substituting human/animal-based bone grafts.

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Section: Polymer-based Bone Substitutesmentioning

confidence: 99%

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

et al. 2021

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“…Biomacromolecules that act as coating layers, like dextran, [89,164,165] chitosan, [166,167] gelatin, [168,169] and bovine serum albumin (BSA), [157,170,171] play a prominent role in improving the biocompatibility of tracers.…”

Section: Biomacromoleculementioning

confidence: 99%

Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

Xie,

Zhai,

Zhou

et al. 2023

Advanced Materials

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Magnetic particle imaging (MPI) is an emerging non‐invasive tomographic technique based on the response of magnetic nanoparticles (MNPs) to oscillating drive fields at the center of a static magnetic gradient. In contrast with magnetic resonance imaging (MRI), which is driven by uniform magnetic fields and projects the anatomic information of the subjects, MPI directly tracks and quantifies MNPs in vivo without background signals. Moreover, it does not require radioactive tracers and has no limitations on imaging depth. This review first introduces the basic principles of MPI and important features of MNPs for advanced imaging sensitivity, spatial resolution, and targeted biodistribution. The latest research on optimized MPI tracers is reviewed based on their material composition, physical properties, and surface modifications. Since all the imaging benefits have led to a series of promising biomedical applications, we also discuss recent relational practices of MPI in vascular abnormalities, including cardiovascular and cerebrovascular systems, and cancers. Finally, some considerations of obstructions and recent progress closely related to the clinical translation of MPI are summarized to provide possible direction for future research and development.This article is protected by copyright. All rights reserved

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“…Various natural and synthetic polymers have been employed as scaffolds with fibrous matrices for tissue regeneration . The advantage of synthetic polymers is that they are manufactured in reproducible large‐scale production processes with controlled mechanical properties, degradation rates, and microstructures.…”

Section: Introductionmentioning

confidence: 99%

Polyurethane fibrous membranes tailored by rotary jet spinning for tissue engineering applications

Rodrigues

Tamborlin

Rodrigues

et al. 2019

J of Applied Polymer Sci

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Polymeric membranes have gained popularity as fibrous structures for tissue regeneration. This research focuses on the rotary jet spinning (RJS) process combined with a polymer as a strategy for designing membranes. To this end, RJS‐polyurethane (RJS‐PU) membranes with different microstructures were produced. Considering the effects of solution properties on fiber production, the viscosity of PU solutions was evaluated. Membrane morphology was studied based on scanning electron microscopy and 2D fast Fourier transform analysis. The chemical and thermal properties were characterized by Fourier‐transform infrared spectroscopy and thermogravimetric analysis, respectively. 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide and Live/Dead cell assays were performed to determine the material cytotoxicity by assessment of the profile of proliferation and cell viability. The results indicated that the combination of PU and RJS was an effective one for the production of fibrous structures for tissue engineering applications, demonstrating good compatibility with the cultured osteoblastic cell line. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2020, 137, 48455.

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Modified poly(caprolactone trifumarate) with embedded gelatin microparticles as a functional scaffold for bone tissue engineering

Cited by 5 publications

References 45 publications

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Synthetic Material for Bone, Periodontal, and Dental Tissue Regeneration: Where Are We Now, and Where Are We Heading Next?

Magnetic Particle Imaging: From Tracer Design to Biomedical Applications in Vasculature Abnormality

Polyurethane fibrous membranes tailored by rotary jet spinning for tissue engineering applications

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