β-Hydroxybutyrate dehydrogenase decorated MXene nanosheets for the amperometric determination of β-hydroxybutyrate

Koyappayil, Aneesh; Chavan, Sachin Ganpat; Go, Anna; Hwang, Sei Young

doi:10.1007/s00604-020-04258-y

Cited by 39 publications

(16 citation statements)

References 35 publications

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“…For example, Koyappayil et al reported that Ti 3 C 2 Tx nanosheets decorated with β-hydroxybutyrate dehydrogenase as a transducer platform for developing an electrochemical β-hydroxybutyrate biosensor with amperometric β-hydroxybutyric acid detection. The biosensor displayed a sensitivity of 0.480 µA/(Mm•cm 2 ), a wide linear range from 0.36 to 17.9 mM, and a LOD of 45 µM [168]. Another breakthrough in developing peptide-based electrochemical biosensors was reported by Xu et al, who designed a universal strategy for constructing ratiometric antifouling electrochemical biosensors based on multifunctional peptides 2D MXene nanomaterials loaded with AuNPs and methylene blue (MB) to PSA detection.…”

Section: Examples Of Nanobioengineered Platforms For Electrochemical ...mentioning

confidence: 99%

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

Soto

Orozco

2022

Molecules

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Nanoengineering biosensors have become more precise and sophisticated, raising the demand for highly sensitive architectures to monitor target analytes at extremely low concentrations often required, for example, for biomedical applications. We review recent advances in functional nanomaterials, mainly based on novel organic-inorganic hybrids with enhanced electro-physicochemical properties toward fulfilling this need. In this context, this review classifies some recently engineered organic-inorganic metallic-, silicon-, carbonaceous-, and polymeric-nanomaterials and describes their structural properties and features when incorporated into biosensing systems. It further shows the latest advances in ultrasensitive electrochemical biosensors engineered from such innovative nanomaterials highlighting their advantages concerning the concomitant constituents acting alone, fulfilling the gap from other reviews in the literature. Finally, it mentioned the limitations and opportunities of hybrid nanomaterials from the point of view of current nanotechnology and future considerations for advancing their use in enhanced electrochemical platforms.

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Section: Examples Of Nanobioengineered Platforms For Electrochemical ...mentioning

confidence: 99%

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

Soto

Orozco

2022

Molecules

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“…Operating at −0.35 V vs. Ag/AgCl, the developed biosensor displayed a linear range between 0.36 and 17.9 mM as well as a LOD of 45 µM. The sensor was tested for the determination of β-hydroxybutyrate analyte in (spiked) real serum samples [ 46 ]. Moreover, a mediator-free amperometric biosensor was designed for the detection of phenol.…”

Section: 2d Nanostructures: Synthesis Properties and Integration In Biosensing Designmentioning

confidence: 99%

Two-Dimensional Nanostructures for Electrochemical Biosensor

Khan

Radoi

Rashid

et al. 2021

Sensors

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Current advancements in the development of functional nanomaterials and precisely designed nanostructures have created new opportunities for the fabrication of practical biosensors for field analysis. Two-dimensional (2D) and three-dimensional (3D) nanomaterials provide unique hierarchical structures, high surface area, and layered configurations with multiple length scales and porosity, and the possibility to create functionalities for targeted recognition at their surface. Such hierarchical structures offer prospects to tune the characteristics of materials—e.g., the electronic properties, performance, and mechanical flexibility—and they provide additional functions such as structural color, organized morphological features, and the ability to recognize and respond to external stimuli. Combining these unique features of the different types of nanostructures and using them as support for bimolecular assemblies can provide biosensing platforms with targeted recognition and transduction properties, and increased robustness, sensitivity, and selectivity for detection of a variety of analytes that can positively impact many fields. Herein, we first provide an overview of the recently developed 2D nanostructures focusing on the characteristics that are most relevant for the design of practical biosensors. Then, we discuss the integration of these materials with bio-elements such as bacteriophages, antibodies, nucleic acids, enzymes, and proteins, and we provide examples of applications in the environmental, food, and clinical fields. We conclude with a discussion of the manufacturing challenges of these devices and opportunities for the future development and exploration of these nanomaterials to design field-deployable biosensors.

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“…The developed biosensor best operated at a potential of −0.35 V (vs. Ag/AgCl), displayed a linear range between (0.36 to 17.9 mM), a sensitivity of 0.480 μA mM −1 cm −2 , and a LOD of 45 μM. Later, the biosensor was successfully applied to the determination of β-hydroxybutyrate in (spiked) real serum samples [ 68 ].…”

Section: Classes Of Bioanalytical Sensors Based On Mxenesmentioning

confidence: 99%

MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

Khan

Andreescu

2020

Sensors

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MXenes are recently developed 2D layered nanomaterials that provide unique capabilities for bioanalytical applications. These include high metallic conductivity, large surface area, hydrophilicity, high ion transport properties, low diffusion barrier, biocompatibility, and ease of surface functionalization. MXenes are composed of transition metal carbides, nitrides, or carbonitrides and have a general formula Mn+1Xn, where M is an early transition metal while X is carbon and/or nitrogen. Due to their unique features, MXenes have attracted significant attention in fields such as clean energy production, electronics, fuel cells, supercapacitors, and catalysis. Their composition and layered structure make MXenes attractive for biosensing applications. The high conductivity allows these materials to be used in the design of electrochemical biosensors and the multilayered configuration makes them an efficient immobilization matrix for the retention of activity of the immobilized biomolecules. These properties are applicable to many biosensing systems and applications. This review describes the progress made on the use and application of MXenes in the development of electrochemical and optical biosensors and highlights future needs and opportunities in this field. In particular, opportunities for developing wearable sensors and systems with integrated biomolecule recognition are highlighted.

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β-Hydroxybutyrate dehydrogenase decorated MXene nanosheets for the amperometric determination of β-hydroxybutyrate

Cited by 39 publications

References 35 publications

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

Hybrid Nanobioengineered Nanomaterial-Based Electrochemical Biosensors

Two-Dimensional Nanostructures for Electrochemical Biosensor

MXenes-Based Bioanalytical Sensors: Design, Characterization, and Applications

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