2018
DOI: 10.1038/s41374-017-0009-0
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Abstract: Recently, the significantly higher incidence of Alzheimer's disease (AD) in women than in men has been attributed to the loss of neuroprotective estrogen after menopause. Does phytoestrogen have the ability to protect against amyloid-β (Aβ) toxicity? The aim of this study was to evaluate hypothesis that β-ecdysterone (β-Ecd) protects SH-SY5Y cells from Aβ-induced apoptosis by separate signaling pathways involving protein kinase B (Akt) and c-Jun N-terminal kinase (JNK). Here, we demonstrate that phytoestrogen … Show more

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Cited by 37 publications
(19 citation statements)
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“…14 A recent study reported that βEcd possesses multiple pharmacological actions, including protection against β-amyloid-induced apoptosis. 15,16 Previously, βEcd was shown to increase the differentiation of mesenchymal progenitor cells towards osteoblasts in vitro, which is consistent with the observation of an increased osteoblast surface following in vivo βEcd treatment. 17 In the present study, hBMSCs were cultured with different concentrations of βEcd, and βEcd at 0, 25 and 50 μmol/l had no significant inhibitory effect on hBMSC viability.…”
Section: Discussionsupporting
confidence: 80%
“…14 A recent study reported that βEcd possesses multiple pharmacological actions, including protection against β-amyloid-induced apoptosis. 15,16 Previously, βEcd was shown to increase the differentiation of mesenchymal progenitor cells towards osteoblasts in vitro, which is consistent with the observation of an increased osteoblast surface following in vivo βEcd treatment. 17 In the present study, hBMSCs were cultured with different concentrations of βEcd, and βEcd at 0, 25 and 50 μmol/l had no significant inhibitory effect on hBMSC viability.…”
Section: Discussionsupporting
confidence: 80%
“…Although AD is the most prevalent neurodegenerative disease, affecting over 47 million people globally, no satisfactory treatment has been reported so far (30). Neuronal apoptosis is believed to be one of the key events precipitating AD (31).…”
Section: Discussionmentioning
confidence: 99%
“…Alzheimer's disease (AD), which is caused by the loss of neurons and synapse degeneration, is clinically characterized by changes in cognitive function ( 1 ), which affects >47 million people worldwide ( 2 ). Due to its complex pathological mechanism, its therapeutic targets have not yet been identified ( 3 ).…”
Section: Introductionmentioning
confidence: 99%