β‐Cyclodextrin: A Green and Efficient Supramolecular Catalyst for Organic Transformations

Abstract

β-Cyclodextrin is cyclic oligosaccharide possessing hydrophobic cavity, which binds the substrates selectively and catalyze number of organic transformations with high selectivity. It catalyzes the reaction by non-covalent supramolecular bonding with reversible formation of host-guest complexes as seen in enzymes. This account summarizes our efforts in designing a good number of important organic transformations using β-cyclodextrin and its derivatives. These reactions were performed in neat, aqueous as well as organic media. Greener synthetic routes to a variety of biologically relevant organic molecules has been developed. The temperature, solvent and catalyst amount plays in important role in these reactions. β-Cyclodextrin activates variety of organic compounds like aldehydes, ketones, anhydride, oximes, amines, nitriles and increases the rate of reactions.

Heat-set supramolecular polymer gel and decomposition by guests

“…b-CD can accommodate different guest molecules. [37][38][39] So, the effects of adding guest molecules to stearic acid appended L-lysine 40 1 to the thermo-setting gelB systems were investigated. Due to the formation of the supramolecular polymer through host-guest interaction [41][42][43][44] with compound 1 and b-CD, gelB is thermo irreversible.…”

Cyclodextrin‐Functionalised Nanomaterials for Enantiomeric Recognition

“…[41] They are exploited in differential pulse voltammetry, [42] square wave voltammetry, [43] cyclic voltammetry, [44] and linear sweep voltammetry. [45] Further, CDs are for example used in asymmetric synthesis, [46] as a part of enantioselective sensors [47] and also in nuclear magnetic resonance (NMR) as chiral nuclear magnetic resonance shift reagents. [48] CDs can provide multiple types of interactions to molecules, such as hydrogen bonds, hydrophobic interactions, van der Waals interactions, and charge-transfer interactions [49] (and additional forms in cases with CD derivatives).…”

“…They are exploited in differential pulse voltammetry, square wave voltammetry, cyclic voltammetry, and linear sweep voltammetry . Further, CDs are for example used in asymmetric synthesis, as a part of enantioselective sensors and also in nuclear magnetic resonance (NMR) as chiral nuclear magnetic resonance shift reagents …”

β-Cyclodextrin: a green supramolecular catalyst assisted eco-friendly one-pot three-component synthesis of biologically active substituted pyrrolidine-2-one

“…β-Cyclodextrin activates a variety of organic compounds like aldehydes, ketones, anhydride, oximes, amines, nitriles and increases the rate of reactions. 18 These properties of β-CD recognises it as an important asset for pharmaceutical industries, as well as for synthetic chemistry. Moreover, β-CD is easily available, recyclable, inexpensive, and water-soluble due to the presence of a hydrophilic external part, and is a mild and non-toxic supramolecule.…”