β‐adrenoceptor‐stimulated lipolysis of subcutaneous abdominal adipocytes as a determinant of fat oxidation in obese men

Imbeault,; Tremblay,; Després,; Mauriège,

doi:10.1046/j.1365-2362.2000.00634.x

Cited by 8 publications

(5 citation statements)

References 29 publications

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“…We investigated whether in vitro cellular lipolysis was associated with whole‐body substrate oxidation to establish a possible mechanistic link through which adipocyte lipolysis could affect body weight. Imbeault et al found that in vitro isoproterenol‐stimulated lipolysis was associated with whole‐body oxidation in a study of 20 Caucasian males with obesity . However, substrate oxidation in that study was measured for 15 min in an exclusively fasting state, which may not reflect free‐living substrate oxidation.…”

Section: Discussionmentioning

confidence: 94%

In Vitrolipolysis is associated with whole‐body lipid oxidation and weight gain in humans

Frankl

Piaggi

Foley

et al. 2016

Obesity

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Objectives To assess the association of adipocyte size with cellular lipolysis, and between cellular lipolysis and whole body lipid oxidation. Then, to assess the association between adipocyte size and cellular lipolysis with weight and fat mass gain. Methods Subjects had assessment of percent body fat (%fat) and adipose tissue biopsy for in vitro lipolysis (n=325), and a subset of subjects had measurement of whole body lipid oxidation (n=112). A subset of subjects (n=243) returned for repeat measurements of body weight and composition (mean follow-up 8.2 ± 5.5 years). Results In vitro lipolysis (r=0.47, p<0.0001) and adipocyte size (r=0.49, p<0.0001) were strongly associated with %fat. In vitro lipolysis (p=0.04) but not adipocyte size (p=0.44) was associated with whole body fat oxidation. Adipocyte size was not associated with rate of percent weight gain (p=0.20), but was negatively associated with rate of percent fat mass gain (p=0.01). In vitro lipolysis was negatively associated with rate of percent weight gain (p=0.02) and had a marginal negative association with rate of percent fat mass gain (p=0.08). Conclusions These results indicate inherent characteristics of adipocytes, including size and lipolytic activity, may be important determinants of whole body lipid oxidation and subsequent weight gain.

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Section: Discussionmentioning

confidence: 94%

In Vitrolipolysis is associated with whole‐body lipid oxidation and weight gain in humans

Frankl

Piaggi

Foley

et al. 2016

Obesity

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“…Numerous studies have demonstrated a tight link between lipolysis and FA oxidation during exercise. Indeed, a positive correlation has been observed between lipolytic rate measured in vitro in isolated adipocytes and whole-body resting FA oxidation in healthy individuals (Imbeault et al, 2000). In addition, a strong positive relationship has been described between subcutaneous abdominal WAT lipolysis and whole-body FA oxidation measured during an exercise bout in endurancetrained subjects (Moro et al, 2014).…”

Section: Main Fa Sourcesmentioning

confidence: 99%

Influence of Acute and Chronic Exercise on Abdominal Fat Lipolysis: An Update

et al. 2020

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Exercise is a powerful and effective preventive measure against chronic diseases by increasing energy expenditure and substrate mobilization. Long-duration acute exercise favors lipid mobilization from adipose tissue, i.e., lipolysis, as well as lipid oxidation by skeletal muscles, while chronic endurance exercise improves body composition, facilitates diet-induced weight loss and long-term weight maintenance. Several hormones and factors have been shown to stimulate lipolysis in vitro in isolated adipocytes. Our current knowledge supports the view that catecholamines, atrial natriuretic peptide and insulin are the main physiological stimuli of exercise-induced lipolysis in humans. Emerging evidences indicate that contracting skeletal muscle can release substances capable of remote signaling to organs during exercise. This fascinating crosstalk between skeletal muscle and adipose tissue during exercise is currently challenging our classical view of the physiological control of lipolysis, and provides a conceptual framework to better understand the pleotropic benefits of exercise at the whole-body level.

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“…However, recent research has shown that whole-body lipolytic activity of abdominal adipose tissue is impaired in upper-body obese women (Horowitz and Klein, 2000), and that impaired β-adrenergic-mediated lipolysis is a determinant of low fat oxidation rates in obese men (Imbeault et al, 2000;Snitker et al, 1998). The obese state may then render it difficult to achieve an acute state of negative lipid balance independent of the effects of physical activity.…”

Section: Adrenergic Regulation Of Lipolysismentioning

confidence: 99%

Maximizing Acute Fat Utilization: Effects of Exercise, Food, and Individual Characteristics

Bennard¹,

Imbeault²,

Doucet³

2005

Can. J. Appl. Physiol.

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In discussion of the physiological mechanisms that regulate fat metabolism, and with consideration of the metabolic stimuli that modulate substrate metabolism, the issue of how an acute state of negative lipid balance can be maximized is addressed. The regulation of lipolysis by catecholamines and insulin is reviewed, and the mechanisms of fatty acid mobilization and uptake by muscle are also briefly discussed. The implications of substrate availability and the hormonal response during physiological states such as fasting, exercise, and after food intake are also addressed, with particular regard to the influences on fatty acid mobilization and/or oxidation from eliciting these stimuli conjointly. Finally, a brief discussion is given of both the nature of exercise and the exercising individual, and how these factors influence fat metabolism during exercise. It is also a primary thrust of this paper to underline gaps in the existing literature with regard to exercise timing concerning food ingestion for maximizing acute lipid utilization.

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β‐adrenoceptor‐stimulated lipolysis of subcutaneous abdominal adipocytes as a determinant of fat oxidation in obese men

Abstract: These results suggest that adipose tissue lipolytic activity of subc abdominal adipocytes acts as a determinant of fat oxidation in obese men.

Cited by 8 publications

References 29 publications

In Vitrolipolysis is associated with whole‐body lipid oxidation and weight gain in humans

In Vitrolipolysis is associated with whole‐body lipid oxidation and weight gain in humans

Influence of Acute and Chronic Exercise on Abdominal Fat Lipolysis: An Update

Maximizing Acute Fat Utilization: Effects of Exercise, Food, and Individual Characteristics

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