1998
DOI: 10.1177/096032719801700307
|View full text |Cite
|
Sign up to set email alerts
|

α-Tocopherol (vitamin-E) ameliorates ferric nitrilotriacetate (Fe-NTA)-dependent renal proliferative response and toxicity: diminution of oxidative stress

Abstract: Ferric nitrilotriacetate (Fe-NTA) is a potent nephrotoxic agent. In this communication, we show the modulatory effect of DL-a-tocopherol (Vitamin-E) on ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative stress, toxicity and hyperproliferative response in rats. Fe-NTA-treatment enhances the susceptibility of renal microsomal membrane for iron-ascorbate-induced lipid peroxidation and hydrogen peroxide generation which are accompanied by a decrease in the activities of renal antioxidant enzymes, c… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

3
33
0

Year Published

2003
2003
2017
2017

Publication Types

Select...
10

Relationship

6
4

Authors

Journals

citations
Cited by 37 publications
(38 citation statements)
references
References 36 publications
3
33
0
Order By: Relevance
“…In similar to our results, a number of studies have reported that vitamin E concentration in plasma or tissue from cancer patients and animals treated with cisplatin. Elsendoorn et al (2001) reported no changes in vitamin E levels whereas others have reported decreases (Bogin et al, 1994;Appenroth et al, 1997;Iqbal et al, 1998;Halliwell and Gutteridge, 1999). In this study, ␤-carotene concentrations in the kidney and liver and vitamin E concentrations in the lens and liver of rats treated with cisplatin had significantly lower compared to control group rats.…”
Section: Discussionmentioning
confidence: 90%
“…In similar to our results, a number of studies have reported that vitamin E concentration in plasma or tissue from cancer patients and animals treated with cisplatin. Elsendoorn et al (2001) reported no changes in vitamin E levels whereas others have reported decreases (Bogin et al, 1994;Appenroth et al, 1997;Iqbal et al, 1998;Halliwell and Gutteridge, 1999). In this study, ␤-carotene concentrations in the kidney and liver and vitamin E concentrations in the lens and liver of rats treated with cisplatin had significantly lower compared to control group rats.…”
Section: Discussionmentioning
confidence: 90%
“…Glucose-6-phosphate dehydrogenase activity was assayed by the method of Zaheer et al (1965), as described by Iqbal et al (1998a). The reaction mixture in a total volume of 2.0 ml consisted of 0.45 ml Tris-HCl buffer (0.05 M, pH 7.6), 0.05 ml NADP (0.1 mM), 0.05 ml glucose 6-phosphate (0.8 mM), 0.25 ml MgCl 2 (8 mM), 0.2 ml of renal and hepatic PMS (10% w/v) and 1.0 ml distilled water.…”
Section: Methodsmentioning
confidence: 99%
“…Sesamum indicum extract treatment significantly decreased the levels of blood urea and serum uric acid and creatinine in diabetic rats, which could be due to the prevention of protein and nucleic acid degradation. These results may be attributed to the antioxidant nature of vitamin E present in sesame which acts as a protective agent by breaking the chain reactions of both hydroxyl and peroxyl radicals and by regulating the antioxidative defense enzyme system in the kidney tissues [210]. Azab et al [205] reported that the serum urea, uric acid, and creatinine parameters were significantly increased in mice received lead acetate (500 mg/kg diet) daily for 30 days.…”
Section: Sesame (Sesamum Indicum L)mentioning
confidence: 97%