Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats

Nazıroğlu, Mustafa; Karaoğlu, Aziz; Aksoy, Asude

doi:10.1016/j.tox.2003.10.012

Cited by 324 publications

(234 citation statements)

References 25 publications

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“…Several investigators (18) reported that the alterations induced by cisplatin in the kidney functions were characterized by signs of injury such as increase of products of LPO (lipid peroxide) and changes in GSH levels in kidney tissue, creatinine and urea levels in plasma. The present study showed that administration of cispaltin to rats caused a reduction in glomerular filtration rate, which correlated with increased creatinine and urea in plasma (Table II).…”

Section: Discussionmentioning

confidence: 99%

“…The depletion in the renal GSH level has been observed in rats in response to oxidative stress caused by CDDP treatment (29). It has been suggested that cisplatin is able to generate reactive oxygen species, and that is also inhibits the activity of antioxidant enzymes in renal tissue such as CAT, SOD, GSH-Px (30,18). The antioxidant property of carnosine is important manifestation as it directly interacts with lipid peroxidation products (30).…”

Section: Antioxidant Effect Of Carnosine Pretreatment In Ratsmentioning

confidence: 99%

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Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Noori

Mahboob

2010

Indian J Clin Biochem

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Section: Discussionmentioning

confidence: 99%

Section: Antioxidant Effect Of Carnosine Pretreatment In Ratsmentioning

confidence: 99%

Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Noori

Mahboob

2010

Indian J Clin Biochem

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“…The administration of antioxidants such as vitamin E, vitamin C, lycopene, and melatonin, before or after treatment with cisplatin, has been used to protect or ameliorate against nephrotoxicity in human and animals. [5,6,20,[39][40][41] Much attention has been given to the possible role that dietary antioxidants play in protecting against cisplatin-induced nephrotoxicity. [6,42] Vitamin C is a watersoluble dietary antioxidant that plays an important role in controlling the oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic Study

2008

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The present study was performed to investigate whether the chronic administration of antioxidant vitamin C provided morphological protection on cisplatin-induced renal damage. Wistar albino male rats were divided into control and two experiment groups, each consisting of six rats. Cisplatin (5 mg/kg/ month) was administered intravenously to the second and third group for three months. After the first application of cisplatin, vitamin C (8 mg/kg/day) to the third group was administered intramuscular for 3 months. At the end of the third month, the kidney specimens of the all groups were obtained. All of these kidney specimens were processed for light and electron microscopical examination. In the second group, most of the renal corpuscle lost their normal appearance and size, especially in the corticomedullary region. The most obvious changes were encountered in the proximal tubules. These changes were tubular dilation, thickening of basement membrane, loss of brush border, vacuolization, and swollenness of mitochondria in the proximal tubule epithelial cells. In addition, infiltration foci were observed mainly in the cortical region. In the third group, which was administered cisplatin plus vitamin C, although the structural damages and morphometric changes were lessened, mononuclear cell infiltration was still observed. This study suggests that the chronic administration of vitamin C may be of therapeutic benefit on cisplatin nephrotoxicity.

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“…Nephrotoxicity is a common side effect of cisplatin-based chemotherapeutic regimens (41)(42)(43)(44). Our previous studies demonstrated reduced protein expression and enzyme activities of several kidney PPARα target genes in response to cisplatin nephrotoxicity, and also that the use of PPARα ligands such as fibrate compound Wy-14,643 protected renal function by preventing proximal tubule cell death in the animal models of ischemia-reperfusion and cisplatin-induced acute renal failure (ARF).…”

Section: Metabolomic Study Of Cisplatin Induced Acute Renal Failurementioning

confidence: 99%

Metabolomics as an Extension of Proteomic Analysis: Study of Acute Kidney Injury

Portilla

Schnackenberg

Beger

2007

Seminars in Nephrology

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While proteomics studies the global expression of proteins, metabolomics characterizes and quantifies their end products: the metabolites, produced by an organism under certain set of conditions. From this perspective it is apparent that proteomics and metabolomics are complementary and when joined allow a fuller appreciation of an organism's phenotype. Our studies using 1 H-nuclear magnetic resonance (NMR) spectroscopic analysis demonstrated the presence of glucose, aminoacids, and trichloroacetic acid cycle metabolites in the urine after 48 hr of cisplatin administration. These metabolic alterations precede changes in serum creatinine. Biochemical studies confirmed the presence of glucosuria, but also demonstrated the accumulation of nonesterified fatty acids, and triglycerides in serum, urine, and kidney tissue, in spite of increased levels of plasma insulin. These metabolic alterations were ameliorated by the use of fibrates. We propose that the injury-induced metabolic profile may be used as a biomarker of cisplatin-induced nephrotoxicity. These studies serve to illustrate that metabolomic studies add insight into pathophysiology not provided by proteomic analysis alone.

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Selenium and high dose vitamin E administration protects cisplatin-induced oxidative damage to renal, liver and lens tissues in rats

Cited by 324 publications

References 25 publications

Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Protective Effects of Vitamin C on Cisplatin-Induced Renal Damage: A Light and Electron Microscopic Study

Metabolomics as an Extension of Proteomic Analysis: Study of Acute Kidney Injury

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