Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Noori, Shafaq; Mahboob, Tabassum

doi:10.1007/s12291-010-0018-x

Cited by 89 publications

(68 citation statements)

References 29 publications

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“…Pandir and Kara (2013) clarified that Superoxide Dismutase (SOD), catalase (CAT) and Glutathione Peroxidase (GPx) activities were decreased and malondialdehyde MDA levels were increased in the cisplatin nephrotoxicity group. The obtained results were not in accordance with Noori and Mahboob (2010) who found that oxidative stress is another participating factor associated with cisplatin-induced renal damage. SOD, CAT and GPx activities are increased in cellular membranes due to cisplatininduced nephrotoxicity.…”

Section: Discussioncontrasting

confidence: 94%

Factors Those Up Regulate <i>Klotho</i> and Glutathione Peroxidase-1 Gene Expression Improve Renal Function in Rats with Acute Renal Failure

Elgendey¹,

Hemeda²,

Sosa³

et al. 2015

American Journal of Biochemistry and Biotechnology

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Acute Renal Failure (ARF) has traditionally been defined as the abrupt and progressive loss of kidney functions resulting in the retention of urea and other nitrogenous waste products associated with interstitial inflammation, tubular injury and increasing Tumor Necrosis Factor (TNF). Mortality in patients with ARF remains high >50% in severely ill patients. Klotho gene is a new anti-aging gene. Genetic mutation of klotho gene causes multiple premature aging-like phenotypes and shortens lifespan. Klotho gene is highly expressed in the kidney and a soluble form of klotho functions as an endocrine substance that exerts multiple actions including the modulation of renal solute transport and the protection of the kidney. This study aimed to clarify the pre treatment and/or post treatment effect of vitamin E as an antioxidant on kidney functions, klotho gene expression and glutathione peroxidase-1 gene expression among rats with acute renal failure. Using glycerol as oxidative stress factor to cause acute renal failure and Real time PCR for assessment of gene expression of target gene in the control and treated groups. Our results demonstrated that the vitamin E (α tocopherol) as antioxidant factor decreased the kidney injuries as pre renal failure administer and improve kidney function as post renal failure administer. Those effects were through up regulating the Klotho as anti aging gene and the Glutathione Peroxidase (GPx-1) as antioxidant gene expression in the kidney tissue. We concluded that factors those up regulate the klotho gene expression can use as protective factors against kidney injuries and to improve kidney function in renal failure.

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Section: Discussioncontrasting

confidence: 94%

Factors Those Up Regulate <i>Klotho</i> and Glutathione Peroxidase-1 Gene Expression Improve Renal Function in Rats with Acute Renal Failure

Elgendey¹,

Hemeda²,

Sosa³

et al. 2015

American Journal of Biochemistry and Biotechnology

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“…Oxidative stress is another participating factor associated with cisplatin-induced renal damage. SOD, CAT, and GPx activities are increased in cellular membranes due to cisplatin-induced nephrotoxicity (25). Quercetin is a derivative of a natural flavonoid.…”

Section: Resultsmentioning

confidence: 99%

Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study

Pandır¹,

Kara²

2013

Turk J Med Sci

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IntroductionLactic acid fermentation (LAF) is one of the most practical and widely applied empirical methods for preserving and often enhancing the organoleptic and nutritional quality of fresh vegetables such as cucumbers, cabbages, and olives (Tamang et al. 2005;Di Cagno et al. 2008).Shalgam, a traditional Turkish lactic acid-fermented beverage, is obtained mainly by LAF of black carrot (Daucus carota L.), bulgur bran, rock salt, turnip (Brassica rapa L.), and sourdough, in which lactic acid bacteria (LAB) play an essential role. There are 2 main processing methods for commercial production: the traditional method and the direct method (Erten et al. 2008;Tanguler and Erten 2012a). The traditional method consists of 2 distinct steps: first fermentation and second fermentation (Canbas and Deryaoglu 1993;Erten et al. 2008;Tanguler and Erten 2012a). First fermentation is also called sourdough fermentation. It is carried out for the enrichment of LAB and yeasts. Bulgur flour (3%), rock salt (0.2%), sourdough (0.2%), and adequate table water are mixed and kneaded for the formation of dough. The dough is left for the first fermentation at ambient temperature for 3-5 days. The fermented mixture of bulgur flour and sourdough is extracted with adequate water 3 to 5 times (Erten et al. 2008;Tanguler and Erten 2012a). The second fermentation is also known as the main or carrot fermentation. The extracts obtained from the first fermentation are combined to perform the second fermentation with the roots of black carrot, rock salt (1%-2%), and, if available, sliced turnip (1%-2%) in a tank. Adequate drinkable water is added to fill the tank. The black carrot is washed if necessary. It is sorted to remove all the damaged and defective carrots. The carrot is then cut into pieces of 3-9 cm in length. The second fermentation is naturally carried out for 3 to 10 days at ambient temperature, which can vary from 10 °C to 35 °C (Canbas and Deryaoglu 1993;Erten et al. 2008).In the direct production method, dough fermentation is not carried out. The chopped black carrots, salt, bakers' yeast or sourdough, sliced turnip (if available), and adequate water are transferred to a tank and allowed to ferment at ambient temperature (Tanguler and Erten 2012b). During fermentation, it is mainly LAB that give

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“…Meanwhile, during cisplatin treatment, a robust inflammatory reaction occurs and inflammasomes are also stimulated, further exacerbating renal tissue damage. [18][19][20][21] In our present study, we found that the pretreatment with basal diet supplemented with 2% and 4% O. sanctum significantly attenuated cisplatin-induced nephrotoxicity not only by its antioxidation effect but also by decreasing the expressions of several proinflammatory cytokines. The above findings support the observation of histopathological studies.…”

Section: Discussionmentioning

confidence: 70%

Untitled

Manigauha¹

2017

IJGP

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Background: Nephrotoxicity is a frequent severe side effect of cisplatin chemotherapy, limiting its clinical use despite being one of the most potent chemotherapy drugs. In this study, we investigated the nephroprotective potential of dietary containing Ocimum sanctum against cisplatin-induced nephrotoxicity in rats. Materials and Methods: Adult male rats were randomly divided into four groups with six animals in each group. Groups 1 and 2 were fed basal diet (50% skimmed milk, 36% corn starch, 10% groundnut oil, and 4% mineral and vitamin premix) for 6 weeks. Groups 3 and 4 were fed basal diet supplemented with 2% and 4% O. sanctum leaves, respectively, for 6 weeks. Groups 2-4 received a single intraperitoneal dose of cisplatin (7.5 mg/kg BW) after the 5 th week of the experiment. Histopathological study of kidney was performed using light microscopy. Results: The blood urea, creatinine, uric acid, total protein, blood urea nitrogen (BUN), urine volume, and urine pH were analyzed. The administration of basal diet supplemented with 2% and 4% O. sanctum to rats significantly reduced the creatinine, urea, uric acid, urine pH, BUN, and total protein compared to cisplatin control group, while a significant increase in urine output was observed. Pretreatment with a basal diet supplemented with 2% and 4% O. sanctum were significantly prevented histopathological changes in kidney toward normal. Conclusion: These results suggest that dietary inclusion of O. sanctum could protect against cisplatin-induced nephrotoxicity.

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Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats

Abstract: ABSTRACT

Cited by 89 publications

References 29 publications

Factors Those Up Regulate <i>Klotho</i> and Glutathione Peroxidase-1 Gene Expression Improve Renal Function in Rats with Acute Renal Failure

Factors Those Up Regulate <i>Klotho</i> and Glutathione Peroxidase-1 Gene Expression Improve Renal Function in Rats with Acute Renal Failure

Cisplatin-induced kidney damage and the protective effect of bilberry (Vaccinium myrtillus L.): an experimental study

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