α<sub>2</sub>
-Adrenergic mechanism in menopausal hot flushes

Freedman, R R; Woodward, Suzanne; Sabharwal, SC

doi:10.1016/0020-7292(91)90315-v

Cited by 63 publications

(68 citation statements)

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“…Leading models characterize vasomotor symptoms as thermoregulatory events with involvement of the reproductive hormonal, central adrenergic, and seroto-nergic systems. [30][31][32][33][34][35] The aim of this investigation was to examine the association between childhood abuse and vasomotor symptoms (hot flashes, night sweats) over the menopausal transition. Given the association between childhood abuse and other physical symptoms, reporting of vasomotor symptoms may be elevated among women who have experienced childhood abuse or neglect.…”

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confidence: 99%

“…Given the association between childhood abuse and other physical symptoms, reporting of vasomotor symptoms may be elevated among women who have experienced childhood abuse or neglect. Moreover, childhood abuse and neglect have been associated with behavioral, affective, and neuroendocrine factors also linked to vasomotor symptoms, 15,[30][31][32][33][34][35] including smoking and obesity, [36][37][38] depression and anxiety, 2 and alterations in key neuroendocrine [39][40][41][42][43] and reproductive hormone 44 systems. Thus, we hypothesized that women exposed to childhood abuse or neglect would be more likely to report vasomotor symptoms than women who had not been exposed to abuse or neglect.…”

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Childhood abuse or neglect is associated with increased vasomotor symptom reporting among midlife women

et al. 2008

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Objectives-This study tested the hypothesis that women exposed to childhood abuse or neglect would have an increased likelihood of reporting hot flashes and night sweats during the menopausal transition.Design-This hypothesis was evaluated in 332 white and African American women participating in the Study of Women's Health Across the Nation Mental Health Study, a prospective investigation of women transitioning through menopause. Childhood abuse and neglect were measured once with the Child Trauma Questionnaire. Vasomotor symptoms (any/none hot flashes, night sweats) were reported annually over 8 years. Associations between maltreatment and vasomotor symptoms were estimated with generalized estimating equations.Results-Childhood abuse or neglect was associated with increased reporting of hot flashes (odds ratio = 1.73, 95% CI: 1.23-2.43) and night sweats (odds ratio = 1.75, 95% CI: 1.26-2.43) in ageadjusted models. Results persisted in multivariable models and across several types of abuse and neglect.Conclusions-The experience of childhood abuse and neglect is associated with increased vasomotor symptom reporting in adulthood. The sequelae of childhood abuse and neglect may persist well into adulthood to influence the occurrence of vasomotor symptoms at midlife. KeywordsMenopause; Vasomotor symptoms; Hot flashes; Child abuse; Neglect; Maltreatment Childhood abuse and neglect are highly prevalent in the United States, with estimates in 2004 from the Administration on Children, Youth, and Families indicating rates at 11.2 per 1,000 boys and 12.6 per 1,000 girls. 1 Across multiple investigations experiences of abuse and neglect in childhood have been linked to significantly elevated risk of several adverse health outcomes, including a range of psychiatric disorders, 2-5 substance abuse problems, 2,6 eating disorders, 7,8 and poor self-rated health. 6,9 In the case of physical health conditions, significant associations are most consistently observed for symptomatic conditions that include headache, The aim of this investigation was to examine the association between childhood abuse and vasomotor symptoms (hot flashes, night sweats) over the menopausal transition. Given the association between childhood abuse and other physical symptoms, reporting of vasomotor symptoms may be elevated among women who have experienced childhood abuse or neglect. Moreover, childhood abuse and neglect have been associated with behavioral, affective, and neuroendocrine factors also linked to vasomotor symptoms, 15,[30][31][32][33][34][35] including smoking and obesity, 36-38 depression and anxiety, 2 and alterations in key neuroendocrine [39][40][41][42][43] and reproductive hormone 44 systems. Thus, we hypothesized that women exposed to childhood abuse or neglect would be more likely to report vasomotor symptoms than women who had not been exposed to abuse or neglect. Secondary aims, examined in an exploratory fashion, were (1) to evaluate the association between different types of maltreatment (emotional abuse, physical abuse...

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Childhood abuse or neglect is associated with increased vasomotor symptom reporting among midlife women

et al. 2008

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“…Todo ello se ve refrendado tras la administración de yohimbina (α 2 -antagonista) que eleva las concentraciones hipotalámicas de NA generando sofocos en mujeres ya sintomáticas, mientras que estos ceden tras la administración de clonidina (α 2 -agonista) 44 . La elevada activación neurovegetativa simpática, vehiculizada por el receptor α 2 -adrenérgico juega el papel principal en la activación del sofoco.…”

Section: Resultado: Fisiopatogénesisunclassified

Mecanismo fisiopatológico de los sofocos-sudores inducidos por deprivación androgénica en el carcinoma prostático

et al. 2009

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E l cáncer de próstata es el segundo tumor en importancia en el varón, con aproximadamente 680.000 nuevos casos al año en el mundo y representa el 11,7% de todos los tumores masculinos. En España se diagnostican unos 13.300 casos anuales, lo que representa el 13,6% de los tumores entre los hombres. La incidencia en España, comparada con el resto de países desarrollados, se puede considerar baja (tasa ajustada mundial en 2002: 36 nuevos casos/100.000 habitantes/año) 1,2 .La terapia de deprivación androgénica que se asocia al tratamiento de determinados cánceres de próstata, sea con análogos de la hormona liberadora de gonadotrofinas (LH-RH), antiandrogénicos orales y/o orquidectomía bilateral, inducen a una variada sintomatología hormonodependiente de entre la cual nos referiremos a los sofocos-sudores 3 . A partir de ahora nos referiremos a ellos únicamente como sofocos.En 1896, Cabot estudió los efectos de la castración en el tratamiento del carcinoma prostático describién-dolos por primera vez 4 . Medio siglo después, en 1941 Huggins y Hodges, demostraron la correlación entre cáncer de próstata y andrógenos 5 . También describieron las crisis de sofocos en 9 de 21 pacientes castrados, tras 2 a 3 semanas de la cirugía. ResumenLos sofocos-sudores son problemas frecuentes durante el tratamiento con deprivación androgénica en pacientes afectos de carcinoma prostático. Estos efectos secundarios contribuyen en gran medida al deterioro de la calidad de vida.Se han postulado diferentes hipótesis sobre los mecanismos fisiopatogénicos implicados, todos ellos de una alta complejidad debida básicamente a su multicausalidad.El objetivo de esta revisión es aportar una visión meditada y actualizada de su génesis. La retroalimentación negativa de las hormonas sexuales plasmáticas sobre la secreción hipotalámica de noradrenalina y serotonina serían la causa principal.Asimismo la acción directa de estos mecanismos sobre el centro hipotalámico productor de LH-RH cercano al centro termorregulador, junto al acortamiento del intervalo termoneutral también estarían implicados.La mejor comprensión de su mecanismo de producción nos puede hacer enfocar mas correctamente su tratamiento.Palabras clave: Carcinoma prostático. Sofocos. Deprivación hormonal. Physiopathological mechanism of hot flushes-perspiration induced by androgen deprivation in prostate carcinoma AbstractHot flushes and perspiration are common problems during androgen deprivation therapy for prostate carcinoma, and largely contribute to worsen patient quality of life.Different hypotheses have been proposed to explain the underlying physiopathological mechanisms, though all are very complex, basically because of the multiple causal factors involved.The present review offers a pondered and updated perspective of the origin of hot flushes-perspiration in such patients. Negative feedback of the plasma sexual hormones upon the hypothalamic secretion of noradrenalin and serotonin appears to be the main cause. Likewise, the direct action of such mechanisms upon the LH-RH produ...

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“…But the beliefs regarding menopausal syndrome are different at rural and urban population, thus the present study is an attempt to rule out the myths and to know the prevalence of postmenopausal symptoms among rural and urban population. 6 …”

Section: Introductionmentioning

confidence: 99%

A comparative study on postmenopausal symptoms in rural and urban women

Shilpa

Ugargol

2015

Int J Community Med Public Health

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α₂ -Adrenergic mechanism in menopausal hot flushes

Cited by 63 publications

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Childhood abuse or neglect is associated with increased vasomotor symptom reporting among midlife women

Childhood abuse or neglect is associated with increased vasomotor symptom reporting among midlife women

Mecanismo fisiopatológico de los sofocos-sudores inducidos por deprivación androgénica en el carcinoma prostático

A comparative study on postmenopausal symptoms in rural and urban women

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α2 -Adrenergic mechanism in menopausal hot flushes

Cited by 63 publications

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Childhood abuse or neglect is associated with increased vasomotor symptom reporting among midlife women

Childhood abuse or neglect is associated with increased vasomotor symptom reporting among midlife women

Mecanismo fisiopatológico de los sofocos-sudores inducidos por deprivación androgénica en el carcinoma prostático

A comparative study on postmenopausal symptoms in rural and urban women

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α₂ -Adrenergic mechanism in menopausal hot flushes