α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice

Gonçalves, Rodrigo Lopes Gomes; Cunha, Francisco Valmor Macedo; Sousa-Neto, Benedito P; Oliveira, Leonardo S.; Lopes, M E; Rezende, Diana Carvalho de; Sousa, Ian Jhemes Oliveira; Nogueira, Kerolayne M.; Souza, Luan Kelves Miranda de; Medeiros, Jand Venes Rolim; Wong, Deysi Viviana Tenazoa; Pereira, Vítor Magno; Lima-Júnior, Roberto César Pereira; Sousa, Damião Pergentino de; Oliveira, C P C; Almeida, Fernanda Campos Sousa de; Oliveira, Francisco de Assis

doi:10.1007/s00210-020-01869-3

Cited by 19 publications

(32 citation statements)

References 59 publications

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“…For example, some terpenes (D-Limonene, α-Phellandrene, Terpinolene, Borneol, Linalool, and triterpene glycosides) can reduce the expression of TNF-α, IL-1, and IL-6 in the Raw 264.7 macrophages cell line (Yoon et al, 2010;Huo et al, 2013;de Christo Scherer et al, 2019;Li et al, 2019). Similar results were obtained in experiments using in vivo models such as swiss mice, Wistar rats, and albino mice (BALB/C) (Ramalho et al, 2015;Li et al, 2016;Gonçalves et al, 2020). The authors consider that the inhibitory effects involve the inhibition of the NF-κB signaling pathway.…”

Section: Effect Of Terpenes In Pro-inflammatory Moleculessupporting

confidence: 72%

Therapeutic Applications of Terpenes on Inflammatory Diseases

et al. 2021

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In the last decades, the search for natural products with biological applications as alternative treatments for several inflammatory diseases has increased. In this respect, terpenes are a family of organic compounds obtained mainly from plants and trees, such as tea, cannabis, thyme, and citrus fruits like lemon or mandarin. These molecules present attractive biological properties such as analgesic and anticonvulsant activities. Furthermore, several studies have demonstrated that certain terpenes could reduce inflammation symptoms by decreasing the release of pro-inflammatory cytokines for example, the nuclear transcription factor-kappa B, interleukin 1, and the tumor necrosis factor-alpha. Thus, due to various anti-inflammatory drugs provoking side effects, the search and analysis of novel therapeutics treatments are attractive. In this review, the analysis of terpenes’ chemical structure and their mechanisms in anti-inflammatory functions are addressed. Additionally, we present a general analysis of recent investigations about their applications as an alternative treatment for inflammatory diseases. Furthermore, we focus on terpenes-based nanoformulations and employed dosages to offer a global perspective of the state-of-the-art.

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Section: Effect Of Terpenes In Pro-inflammatory Moleculessupporting

confidence: 72%

Therapeutic Applications of Terpenes on Inflammatory Diseases

et al. 2021

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“…Curcumin, ternatin, spirulina, Phyllanthus niruri , alpha phellandrene, Ipomoea obscura , and the inner bark of Caesalpinia pyramidalis have all been proven to be effective antioxidants in the treatment of CYP-induced IC. 7 , 15 , 16 , 21 …”

Section: Discussionmentioning

confidence: 99%

“…Bladder edema was reported as an increase in bladder wet weight, expressed in milligrams. 16 Gray’s criteria was followed for the gross examination of hemorrhage and edema of urinary bladders. All bladders were excised and transacted at the bladder neck.…”

Section: Methodsmentioning

confidence: 99%

“…After being weighing and microtomized, bladders were preserved in formalin solution (10%), diaphanized, and embedded in paraffin; these were stained with haematoxylin and eosin (H&E) and assessed in an optical microscope by two trained clinical analysts through blind inspection, each specimen was examined by a pathologist who was unaware of the treatment and took into consideration the existence and severity of edema, tissue damage, and hemorrhage. 16 …”

Section: Methodsmentioning

confidence: 99%

“…Following the rats having been euthanized, an explorative laparotomy was performed, and the animal’s bladder was removed, drained, and weighed. Bladder edema was reported as an increase in bladder wet weight, expressed in milligrams . Gray’s criteria was followed for the gross examination of hemorrhage and edema of urinary bladders.…”

Section: Methodsmentioning

confidence: 99%

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Boswellic Acids, Pentacyclic Triterpenes, Attenuate Oxidative Stress, and Bladder Tissue Damage in Cyclophosphamide-Induced Cystitis

et al. 2022

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Boswellic acids, derived from the Boswellia serrata plant, have been demonstrated to have anti-inflammatory properties in experimental animal models. The present study was aimed to evaluate the uro-protective effect of boswellic acids in rats with cyclophosphamide-induced cystitis. Interstitial cystitis was induced by cyclophosphamide (CYP). In order to analyze the reduction of the urothelial damage, the bladder weight, the nociception response, and the Evans blue dye extravasation from the bladder were evaluated. To investigate the involvement of lipid peroxidation and enzymatic antioxidants CAT, SOD, and GPX and MPO and NO were evaluated. IL-6 and TNF-α were measured by the ELISA immunoassay technique. The results showed that pretreatment with boswellic acids significantly reduced urothelial damage which was accompanied by a decrease in the activity of MDA, CPO, and NO levels and prevention of the depletion of CAT, SOD, and GPX. The levels of IL-6 and TNF-α were dramatically reduced by boswellic acids. Histopathological findings revealed a considerable reduction in cellular infiltration, edema, epithelial denudation, and bleeding. Our findings showed that boswellic acids, by their antioxidant and anti-inflammatory properties, negate the detrimental effects of cyclophosphamide on the bladder, suggesting boswellic acids as promising therapeutic alternatives for cystitis.

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Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and in Silico Investigations

Anjum,

Ali,

Bourhia

et al. 2023

Chemistry & Biodiversity

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This study aimed to investigate the effect of aqueous ethanol extract of Cuminum cyminum (AEECC) on oxidative stress, inflammation and overactivity of the urinary bladder induced by cyclophosphamide (CYP). The enhanced nociception behavior, bladder weight, vascular permeability, edema, hemorrhage, nitric oxide, IL‐6 and TNF‐α levels by CYP administration were significantly reduced by AEECC (250 and 500 mg/kg). A significant increase in serum antioxidant systems such as CAT and GPx was also observed in AEECC‐treated rats. The AEECC (3 mg/ml) significantly reduced urinary bladder tone in the strips pre‐contracted with carbachol in both control and CYP‐treated rats. This relaxation was demolished by atropine, nifedipine, glibenclamide, and indomethacin but not with propranolol. The plant extract showed the presence of antioxidant and anti‐inflammatory phytochemicals. These results suggest that Cuminum cyminum offers uroprotective activity and can ameliorate CYP‐induced bladder toxicity by modulating antioxidant parameters, pro‐inflammatory cytokine levels and bladder smooth muscle overactivity. The in silico binding interactions of anti‐oxidant 2I3Y and anti‐inflammatory protein 1TNF with various ligands from Cuminum cyminum seeds reveal potential bioactive compounds with promising anti‐oxidant and anti‐inflammatory properties, providing valuable insights for drug development and nutraceutical research

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α-Phellandrene attenuates tissular damage, oxidative stress, and TNF-α levels on acute model ifosfamide-induced hemorrhagic cystitis in mice

Cited by 19 publications

References 59 publications

Therapeutic Applications of Terpenes on Inflammatory Diseases

Therapeutic Applications of Terpenes on Inflammatory Diseases

Boswellic Acids, Pentacyclic Triterpenes, Attenuate Oxidative Stress, and Bladder Tissue Damage in Cyclophosphamide-Induced Cystitis

Cuminum cyminum Ameliorates Urotoxic Effects of Cyclophosphamide by Modulating Antioxidant, Inflammatory Cytokines, and Urinary Bladder Overactivity: In vivo and in Silico Investigations

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