α-Amylase and α-glucosidase inhibitory activities of the herbs of Artemisia dracunculus L. and its active constituents

Güvenalp, Zühal; Özbek, Hikmet; Dursunoğlu, B; Yuca, Hafize; Gözcü, Sefa; Çil, Yeşim Mualla; Kazaz, Cavit; Kara, Kemalettin; Demirezer, Ömür L.

doi:10.1007/s00044-017-2014-7

Cited by 25 publications

(16 citation statements)

References 17 publications

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“…(5) (6) Previous reports demonstrated that alkylamides such as pellitorine, neopellitorine A, neopellitorine B, undeca-2E,4E-dien-8,10-dynoic acid isobutylamide (4) and undeca-2E,4E-dien-8,10-dynoic acid piperidylamide (5) are the characteristic metabolites of A. dracunculus, besides herniarin (3), which is the characteristic and major metabolite. [1,5,14,16]. As shown in Figure 1, in the current study, two alkylamides, undeca-2E,4E-dien-8,10-dynoic acid isobutylamide (4) and undeca-2E,4E-dien-8,10-dynoic acid piperidylamide (5) were isolated.…”

Section: Chemical Composition Of a Dracunculussupporting

confidence: 55%

“…This species is cultivated in the various region of the world such as southern Europe, Russia, Turkey as well as United States due to its usage as a spice in sauces and soups. Like many Artemisia species, A. dracunculus, an important medicinal and aromatic plant has been used in the treatment of various diseases in traditional medicine since centuries [1,5]. In traditional medicine in Anatolia, it possesses the common uses as digestive, diuretic, appetitive, emmenagogue, carminative, anthelmintic and antidiarrheal [5].…”

Section: Introductionmentioning

confidence: 99%

“…Like many Artemisia species, A. dracunculus, an important medicinal and aromatic plant has been used in the treatment of various diseases in traditional medicine since centuries [1,5]. In traditional medicine in Anatolia, it possesses the common uses as digestive, diuretic, appetitive, emmenagogue, carminative, anthelmintic and antidiarrheal [5]. In the past, it was also used to malign ulcer treatment and plague epidemic in Armenia and it was used to for treat the epilepsy in traditional medicine in Europe [4].…”

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic Anhydrase I (hCA I) and II (hCA II)

Aydın¹,

Yurtvermez²,

Şentürk³

et al. 2019

Rec.Nat.Prod.

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Tarragon or Dragon's-wort (Artemisia dracunculus L.) is widely used as spice and in traditional medicine in various regions of the world. Inhibitory effects of the n-hexane, dichloromethane, ethanol and methanol extracts of the leaves of tarragon on the human carbonic anhydrase (hCA) I and II enzymes were investigated. Dichloromethane extract exhibited the strongest activity with lowest IC50 value (0.020 and 0.031 μg/mL, respectively). The chromatographic studies on the dichloromethane extract of tarragon allowed the isolation of six known strong inhibitors of hCA isozymes as trans-anethole, stigmasterol, herniarin, (2E,4E)-N-isobutylundeca-2,4-dien-8,10diynamide, (2E,4E)-1-(piperidin-1-yl)undeca-2,4-diene-8,10-diyn-1-one and 1-(4'-methoxyphenyl)-1,2,3trihydroxypropane. The compound, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane was isolated from tarragon for the first time in this study. Among the tested compounds, 1-(4'-methoxyphenyl)-1,2,3-trihydroxypropane showed the highest inhibitiory impact on both hCA isozymes. Also its IC50 values were found lower than positive control, acetazolamide.

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Section: Chemical Composition Of a Dracunculussupporting

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic Anhydrase I (hCA I) and II (hCA II)

Aydın¹,

Yurtvermez²,

Şentürk³

et al. 2019

Rec.Nat.Prod.

Self Cite

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“…Lippia sidoides Aqueous extract Ethanolic extract Inhibition before exposure Inhibition after exposure Inhibition before exposure Inhibition after exposure (IEU) [a] (%) (IEU) [ decreased absorption and consequent reduction of postprandial glucose levels and caloric availability. [38] Acarbose and miglitol are allopathic oral hypoglycemic agents with the mechanism of action related to the inhibition of α-glycosidase. However, they cause side effects such as diarrhea, abdominal cramps, and flatulence.…”

Section: Enzymementioning

confidence: 99%

Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis

Braga

Abreu

Trento

et al. 2019

Chemistry & Biodiversity

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The aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A2 present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. jararacussu and B. moojeni venoms in the proportions between 1 : 0.5 and 1 : 5 (venom/extracts (w/w)). They inhibited the thrombolysis induced by B. moojeni (10 to 25 %), potentiated the thrombolysis induced by the Lachesis muta muta venom (30 to 80 %), prolonged the coagulation time induced by B. moojeni and L. muta muta venoms, and presented antigenotoxic action. Both extracts reduced the activity of α‐glycosidases, the aqueous extract inhibited lipases, and the ethanolic extract inhibited α‐amylases. The results demonstrate the modulatory action of the extracts on proteases, phospholipases, and digestive enzymes. In addition, the rich phenolic composition of these extracts highlights their potential for nutraceutical use.

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“…The standard drugs available in the market to control lipase enzyme is orlistat, and for α-amylase inhibition [12], Acarbose is the marketed drug. They have various side-effects like liquid stools, steatorrhea, abdominal cramping and fat-soluble vitamin deficiencies, fecal urgency, incontinence, flatulence [10].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Evaluation of α-Amylase and Lipase Inhibitory Activities of Synthetic Coumarin Derivatives

Mangalpady¹,

Anil²,

N³

2019

Preprint

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This research work involved synthesis of nine Coumarin-hydrazone derivatives and study of their enzyme inhibition activity. The purpose of the study was to investigate the α-amylase and lipase inhibition activity of the synthesized coumarin derivatives. The experiment was performed by taking 5, 10, 50,100 μg/mL of each of the compounds and Acarbose and Orlistat was taken as a positive control. The studies showed that compound 5d (120.6 μM), 5e (111.5 μM) and 5h (124.0 μM) was showing better inhibition activity against α-amylase enzyme, in comparison with the standard (IC50=81.70 μM). The lipase enzyme inhibition revealed that the compounds, 5c (142.3 μM), 5d (82.3 μM) and 5i (93.6 μM) showed better inhibition compared to the standard (IC50=236.4±2.83 μM). The enzyme kinetics study also revealed good results and it has been discussed in the results section.

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α-Amylase and α-glucosidase inhibitory activities of the herbs of Artemisia dracunculus L. and its active constituents

Cited by 25 publications

References 17 publications

Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic Anhydrase I (hCA I) and II (hCA II)

Inhibitory Effects of Metabolites Isolated from Artemisia dracunculus L. Against the Human Carbonic Anhydrase I (hCA I) and II (hCA II)

Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis

Synthesis and Evaluation of α-Amylase and Lipase Inhibitory Activities of Synthetic Coumarin Derivatives

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