2019
DOI: 10.1002/cbdv.201800558
|View full text |Cite
|
Sign up to set email alerts
|

Prospection of Enzyme Modulators in Aqueous and Ethanolic Extracts of Lippia sidoides Leaves: Genotoxicity, Digestion, Inflammation, and Hemostasis

Abstract: The aqueous and ethanolic extracts of Lippia sidoides Cham. were chemically characterized and tested for their action on enzymes involved in processes such as inflammation, blood coagulation, and digestion. Both extracts potentiated the activity of phospholipases A2 present in the venom of Bothrops atrox in 12 % and completely inhibited the hemolysis induced by B. jararacussu and B. moojeni venoms in the proportions between 1 : 0.5 and 1 : 5 (venom/extracts (w/w)). They inhibited the thrombolysis induced by B.… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2021
2021
2023
2023

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 54 publications
0
2
0
Order By: Relevance
“…A recent report by Aparecida Braga et al (2019), evaluated the α‐glucosidase and α‐amylase inhibitory of aqueous and ethanolic extracts from the leaves of Lippia sidoides . Their results showed that ethanolic extracts had an α‐amylase inhibitory activity of 62.50 μmol/min g, which equals around 68.12% inhibition; the inhibitory effect was maintained after simulated gastrointestinal digestion.…”
Section: Protective Effects Of Oregano Phenolic Compounds Against Dia...mentioning
confidence: 99%
“…A recent report by Aparecida Braga et al (2019), evaluated the α‐glucosidase and α‐amylase inhibitory of aqueous and ethanolic extracts from the leaves of Lippia sidoides . Their results showed that ethanolic extracts had an α‐amylase inhibitory activity of 62.50 μmol/min g, which equals around 68.12% inhibition; the inhibitory effect was maintained after simulated gastrointestinal digestion.…”
Section: Protective Effects Of Oregano Phenolic Compounds Against Dia...mentioning
confidence: 99%
“…Several investigations involve mechanisms of action of natural compounds that act as enzymatic inhibitors, and the main classes of toxins used as targets are those involved in inflammatory response and hemostasis (phospholipases A2, metalloproteases, and serine proteases) (Bijak et al, 2014;Braga et al, 2019;Marques et al, 2019). However, mechanisms of interaction between enzymes and natural compounds are poorly described and require extensive studies of structural and functional characterization (Mourada-Silva et al, 2016), thus enabling future applications of these compounds in the therapy of human diseases.…”
Section: Introductionmentioning
confidence: 99%