Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants

Golabchi, Asiyeh; Wu, Bingchen; Cao, Bin; Bettinger, Christopher J.; Cui, Xiufang

doi:10.1016/j.biomaterials.2019.119519

Cited by 91 publications

(106 citation statements)

References 111 publications

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“…For example, another antifouling coating made of PSBMA and polydopamine composite has been shown to reduce glial reaction around coated probes 1 week postimplantation in mice. [ 62 ] In addition, a neuroadhesive protein L1 coating was found to reduce the initial microglial surface coverage at 2 and 6 h postimplant, [ 71 ] and the same coating elicited significantly less chronic inflammatory gliosis after 1, 4, and 8 weeks. [ 96,105 ]…”

Section: Discussionmentioning

confidence: 99%

“…PDA was codeposited to improve the stability of zwitterionic catechol–PSBMA. [ 62 ] Histological results revealed decreased activation of microglia and astrocytes near the catechol–PSBMA–PDA coated neural implants at 1 week postimplant. This promising result motivated us to further optimize the zwitterionic coating and investigate how zwitterionic coatings interact with the brain tissue at high temporal and spatial resolution.…”

Section: Introductionmentioning

confidence: 99%

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Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo

Yang

Eles

et al. 2020

Adv. Biosys.

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For brain computer interfaces (BCI), the immune response to implanted electrodes is a major biological cause of device failure. Bioactive coatings such as neural adhesion molecule L1 have been shown to improve the biocompatibility, but are difficult to handle or produce in batches. Here, a synthetic zwitterionic polymer coating, poly(sulfobetaine methacrylate) (PSBMA) is developed for neural implants with the goal of reducing the inflammatory host response. In tests in vitro, the zwitterionic coating inhibits protein adsorption and the attachment of fibroblasts and microglia, and remains stable for at least 4 weeks. In vivo two‐photon microscopy on CX3CR1‐GFP mice shows that the zwitterionic coating significantly suppresses the microglial encapsulation of neural microelectrodes over a 6 h observation period. Furthermore, the lower microglial encapsulation on zwitterionic polymer‐coated microelectrodes is revealed to originate from a reduction in the size but not the number of microglial end feet. This work provides a facile method for coating neural implants with zwitterionic polymers and illustrates the initial interaction between microglia and coated surface at high temporal and spatial resolution.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo

Yang

Eles

et al. 2020

Adv. Biosys.

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“…Zwitterionic polymers such as poly(sulfobetaine methacrylate) with antifouling properties can be deposited by dipcoating, which is a widely used method for the deposition of polymers. [74] Combined with polydopamine, the zwitterionic polymer improved anti-inflammatory response by the host. Polydopamine can thus be used for the improvement of coating stability, but also the immobilization of molecules on the surface, thanks to its adhesive properties.…”

Section: Surface Modification By Macromoleculesmentioning

confidence: 99%

Recent Advances in Antiinflammatory Material Design

Lebaudy

Fournel

Lavalle

et al. 2020

Adv Healthcare Materials

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Implants and prostheses are widely used to replace damaged tissues or to treat various diseases. However, besides the risk of bacterial or fungal infection, an inflammatory response usually occurs. Here, recent progress in the field of anti‐inflammatory biomaterials is described. Different materials and approaches are used to decrease the inflammatory response, including hydrogels, nanoparticles, implant surface coating by polymers, and a variety of systems for anti‐inflammatory drug delivery. Complex multifunctional systems dealing with inflammation, microbial infection, bone regeneration, or angiogenesis are also described. New promising stimuli‐responsive systems, such as pH‐ and temperature‐responsive materials, are also being developed that would enable an “intelligent” antiinflammatory response when the inflammation occurs. Together, different approaches hold promise for creation of novel multifunctional smart materials allowing better implant integration and tissue regeneration.

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“…Non-specific adhesion or host response, is one of the most important problems in biological safety evaluation [ 1–5 ]. The host response is usually accompanied with acute inflammation, which may lead to severe complications of intravenous devices.…”

Section: Introductionmentioning

confidence: 99%

“…To avoid non-specific adhesion of molecules and cells onto the device, surface with good anti-adhesion property is required. The introduction of functional molecules [ 1 , 3–6 , 18–21 ] has become one of the most important strategies for surface modification due to the optionality of raw materials. Up to now, immobilization of one kind of molecule and co-immobilization of more than two kinds of molecules have been reported in PUs surface modifications and great progress has been realized [ 22–28 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

Cai

et al. 2020

Regenerative Biomaterials

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Polyurethanes are widely used in interventional devices due to the excellent physicochemical property. However, non-specific adhesion and severe inflammatory response of ordinary polyurethanes may lead to severe complications of intravenous devices. Herein, a novel phospholipid-based polycarbonate urethanes (PCUs) were developed via two-step solution polymerization by direct synthesis based on functional raw materials. Furthermore, PCUs were coated on biomedical metal sheets to construct biomimetic anti-fouling surface. The results of stress–strain curves exhibited excellent tensile properties of PCUs films. Differential scanning calorimetry results indicated that the microphase separation of such PCUs polymers could be well regulated by adjusting the formulation of chain extender, leading to different biological response. In vitro blood compatibility tests including bovine serum albumin adsorption, fibrinogen adsorption and denaturation, platelet adhesion and whole-blood experiment showed superior performance in inhibition non-specific adhesion of PCUs samples. Endothelial cells and smooth muscle cells culture tests further revealed a good anti-cell adhesion ability. Finally, animal experiments including ex vivo blood circulation and subcutaneous inflammation animal experiments indicated a strong ability in anti-thrombosis and histocompatibility. These results high light the strong anti-adhesion property of phospholipid-based PCUs films, which may be applied to the blood-contacting implants such as intravenous catheter or antithrombotic surface in the future.

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Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants

Cited by 91 publications

References 111 publications

Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo

Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo

Recent Advances in Antiinflammatory Material Design

Preparation of phospholipid-based polycarbonate urethanes for potential applications of blood-contacting implants

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