Recent Advances in Antiinflammatory Material Design

Lebaudy, Eloïse; Fournel, Sylvie; Lavalle, Philippe; Vrana, Nihal Engin; Gribova, Varvara

doi:10.1002/adhm.202001373

Cited by 39 publications

(28 citation statements)

References 174 publications

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“…In addition, several studies have shown that modifications in polymer surface nanotopography (i.e., surface roughness) can lead to increased chondrocyte density and protein production due to enhanced protein binding on micro-and nano-rough surfaces (Storey and Webster, 2014). Advances in anti-inflammatory polymers or polymeric coatings may be of great use to this field as well-this is an active area of research for surgical implants in general, reviewed recently by both Sánchez-Bodón et al and Lebaudy et al (Bridges and García, 2008;Al-Khoury et al, 2019;Lebaudy et al, 2021;Sánchez-Bodón et al, 2021). Recent work in this field has also evolved to incorporate decellularized extracellular matrix (dECM) from cartilage and IVD into 3D-printable bioinks to aid in guiding cell proliferation, attachment, and differentiation (Vernengo et al, 2020).…”

Section: Future Outlookmentioning

confidence: 99%

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

Perera

Ivone

Natekin

et al. 2021

Front. Bioeng. Biotechnol.

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Cartilage defects pose a significant clinical challenge as they can lead to joint pain, swelling and stiffness, which reduces mobility and function thereby significantly affecting the quality of life of patients. More than 250,000 cartilage repair surgeries are performed in the United States every year. The current gold standard is the treatment of focal cartilage defects and bone damage with nonflexible metal or plastic prosthetics. However, these prosthetics are often made from hard and stiff materials that limits mobility and flexibility, and results in leaching of metal particles into the body, degeneration of adjacent soft bone tissues and possible failure of the implant with time. As a result, the patients may require revision surgeries to replace the worn implants or adjacent vertebrae. More recently, autograft – and allograft-based repair strategies have been studied, however these too are limited by donor site morbidity and the limited availability of tissues for surgery. There has been increasing interest in the past two decades in the area of cartilage tissue engineering where methods like 3D bioprinting may be implemented to generate functional constructs using a combination of cells, growth factors (GF) and biocompatible materials. 3D bioprinting allows for the modulation of mechanical properties of the developed constructs to maintain the required flexibility following implantation while also providing the stiffness needed to support body weight. In this review, we will provide a comprehensive overview of current advances in 3D bioprinting for cartilage tissue engineering for knee menisci and intervertebral disc repair. We will also discuss promising medical-grade materials and techniques that can be used for printing, and the future outlook of this emerging field.

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Section: Future Outlookmentioning

confidence: 99%

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

Perera

Ivone

Natekin

et al. 2021

Front. Bioeng. Biotechnol.

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“…[ 1a ] Materials trying to overcome this problem, and more particularly inducing macrophage differentiation into M2 (proresolving) instead of M1 (proinflammatory) phenotype are also under development. [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

Polyarginine as a Simultaneous Antimicrobial, Immunomodulatory, and miRNA Delivery Agent within Polyanionic Hydrogel

Gribova

Petit

Seguin

et al. 2022

Macromolecular Bioscience

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Implantation of biomedical devices is followed by immune response to the implant, as well as occasionally bacterial, yeast, and/or fungal infections. In this context, new implant materials and coatings that deal with medical device‐associated complications are required. Antibacterial and anti‐inflammatory materials are also required for wound healing applications, especially in diabetic patients with chronic wounds. In this work, hyaluronic acid (HA) hydrogels with triple activity: antimicrobial, immunomodulatory, and miRNA delivery agent, are presented. It is demonstrated that polyarginine with a degree of polymerization of 30 (PAR30), which is previously shown to have a prolonged antibacterial activity, decreases inflammatory response of lipopolysaccharide‐stimulated macrophages. In addition, PAR30 accelerates fibroblast migration in macrophage/fibroblast coculture system, suggesting a positive effect on wound healing. Furthermore, PAR30 allows to load miRNA into HA hydrogels, and then to deliver them into the cells. To the authors knowledge, this study is the first describing miRNA‐loaded hydrogels with antibacterial effect and anti‐inflammatory features. Such system can become a tool for the treatment of infected wounds, e.g., diabetic ulcers, as well as for foreign body response modulation.

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“…Biomaterial-based therapy is a useful method to improve bone regeneration; however, its underlying repair mechanism is not yet elucidated [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. About 30 years ago, the French surgeon Alain-Charles Masquelet developed a new technique to repair bone defects called the Masquelet induced membrane [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Macrophages Characterization in an Injured Bone Tissue

Nikovics¹,

Durand

Castellarin³

et al. 2022

Biomedicines

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Biomaterial use is a promising approach to facilitate wound healing of the bone tissue. Biomaterials induce the formation of membrane capsules and the recruitment of different types of macrophages. Macrophages are immune cells that produce diverse combinations of cytokines playing an important role in bone healing and regeneration, but the exact mechanism remains to be studied. Our work aimed to identify in vivo macrophages in the Masquelet induced membrane in a rat model. Most of the macrophages in the damaged area were M2-like, with smaller numbers of M1-like macrophages. In addition, high expression of IL-1β and IL-6 cytokines were detected in the membrane region by RT-qPCR. Using an innovative combination of two hybridization techniques (in situ hybridization and in situ hybridization chain reaction (in situ HCR)), M2b-like macrophages were identified for the first time in cryosections of non-decalcified bone. Our work has also demonstrated that microspectroscopical analysis is essential for macrophage characterization, as it allows the discrimination of fluorescence and autofluorescence. Finally, this work has revealed the limitations of immunolabelling and the potential of in situ HCR to provide valuable information for in vivo characterization of macrophages.

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Recent Advances in Antiinflammatory Material Design

Cited by 39 publications

References 174 publications

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

3D Bioprinted Implants for Cartilage Repair in Intervertebral Discs and Knee Menisci

Polyarginine as a Simultaneous Antimicrobial, Immunomodulatory, and miRNA Delivery Agent within Polyanionic Hydrogel

Macrophages Characterization in an Injured Bone Tissue

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