Zwitterionic Polydopamine Engineered Interface for In Vivo Sensing with High Biocompatibility

Abstract

Electrochemical sensing performance is often compromised by electrode biofouling (e.g., proteins nonspecific binding) in complex biological fluids; however, the design and construction of a robust biointerface remains a great challenge. Herein, inspired by nature, we demonstrate a robust polydopamine‐engineered biointerfacing, to tailing zwitterionic molecules (i.e., sulfobetaine methacrylate, SBMA) through Michael Addition. The SBMA‐PDA biointerface can resist proteins nonspecific binding in complex biological fluids while enhancing interfacial electron transfer and electrochemical stability of the electrode. In addition, this sensing interface can be integrated with tissue‐implantable electrode for in vivo analysis with improved sensing performance, preserving ca. 92.0% of the initial sensitivity after 2 h of implantation in brain tissue, showing low acute neuroinflammatory responses and good stability both in normal and in Parkinson′s disease (PD) rat brain tissue.

Polydopamine/poly(sulfobetaine methacrylate) Co-deposition coatings triggered by CuSO4/H2O2 on implants for improved surface hemocompatibility and antibacterial activity

“…1 c), which became more hydrophilic after incorporation of PSBMA. The increase of thickness makes the surface of the coating contain more copper ions and zwitterions, which endows the surface with antibacterial and hydrophilic properties, and good hydrophilicity to effectively inhibit the adsorption of bacteria, platelets and non-specific proteins on the surface [ 48 , 49 ].…”

Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

“…The strong reducibility of catechol groups inspired us to introduce them to gelatin backbone to enhance the biomineralization ability of gelatin. [ 8c,9 ] To the best of our knowledge, there have been literatures that grafting dopamine (DA) on the macromolecule, such as hyaluronic acid, [ 21 ] sodium alginate, [ 22 ] and sulfobetaine methacrylate, [ 23 ] can endow them with various excellent properties. However, it has not been reported to enhance the biomineralization ability of gelatin by DA‐modification, thereby giving it a wider range of applications in wound dressings.…”

Mesoporous Polydopamine Nanoparticles Attenuate Morphine Tolerance in Neuropathic Pain Rats by Inhibition of Oxidative Stress and Restoration of the Endogenous Antioxidant System

“…Due to its ease of synthesis and comparable chemical and physical properties to that of natural melanin, PDA has attracted considerable attention in the fields of biomedicine [ 17 ]. PDA has excellent biocompatibility and biodegradability in vivo without any cytotoxic effects [ 18 , 19 ]. Furthermore, its antibacterial, cell adhesion and cell proliferation properties make it an ideal material for surface coating of implants and other inorganic nanocarriers used for biological applications [ 20 , 21 ].…”