Multifunctional Injectable Hydrogel Dressings for Effectively Accelerating Wound Healing: Enhancing Biomineralization Strategy

Abstract

Bacterial infection can cause chronic nonhealing wounds, which may be a great threat to public health. It is highly desirable to develop an injectable wound dressing hydrogel with multifunctions including self‐healing, remodeling, antibacterial, radical scavenging ability, and excellent photothermal properties to promote the regeneration of damaged tissues in clinical practice. In this work, dopamine‐modified gelatin (Gel‐DA) is employed for the first time as a biotemplate for enhancing the biomineralization ability of gelatin to synthesize dopamine‐modified gelatin@Ag nanoparticles (Gel‐DA@Ag NPs). Further, the prepared Gel‐DA@Ag NPs with antioxidant activity and near‐infrared (NIR) laser irradiation synergistic antibacterial behavior are fixed in the guar gum based hydrogels through the formation of borate/didiol bonds to possess remolding, injectable, and self‐healing performance. In addition, the multifunctional hydrogels can completely cover the irregular wound shape to prevent secondary injury. More importantly, these hydrogel platforms under NIR can significantly accelerate wound healing with more skin appendages like hair follicles and blood vessels appearing. Therefore, it is expected that these hydrogels can serve as competitive multifunctional dressings in biomedical field, including bacteria‐derived wound infection and other tissue repair related to reactive oxygen species overexpression.

Eradication of Mature Bacterial Biofilms with Concurrent Improvement in Chronic Wound Healing Using Silver Nanoparticle Hydrogel Treatment

“…Taken together, these results demonstrate that AgNP hydrogel promotes wound healing, which is consistent with a previous study using a planktonic bacteria wound model, which also showed an improved rate of wound closure in response to AgNP hydrogel treatment [ 59 ]. These results could be attributed to the combined effect of hydrogel biocompatibility and cell proliferative and antibacterial properties of ultra-small AgNPs to effectively eliminate bacterial pathogens and allow wound regeneration.…”

Green Regenerative Hydrogel Wound Dressing Functionalized by Natural Drug‐Food Homologous Small Molecule Self‐Assembled Nanospheres

“…Considering the successful application of enhancing antibacterial and antioxidant strategies in the development of new multifunctional hydrogel wound dressings, [7,10,46] the antibacterial and antioxidant performances of CS-based hydrogels were further evaluated. First, the antibacterial properties of pure CS hydrogels, CA-TA NEs hydrogels and CA-TA-ZA NSs hydrogels were evaluated.…”

A Review on Hydrogels with Photothermal Effect in Wound Healing and Bone Tissue Engineering

“…To promote wound healing, many dressings have been developed to control infection, promote hemostasis, and improve angiogenesis [ 132 , 133 , 134 ]. The development of hydrogel with excellent antibacterial properties, good compatibility, and degradable ability is a promising strategy for wound healing [ 135 , 136 ]. Hydrogels with a photothermal conversion ability can regulate the temperature by changing the NIR irradiation intensity/time, photothermal initiator concentration/ratio, and cycling time [ 137 , 138 ].…”