or centuries, patients and physicians have sought a safe and effective method for treating skin changes associated with photoaging. Currently, a variety of modalities are used to treat facial rhytids, including dermabrasion, chemical peels, and laser skin resurfacing (LSR). Although these modalities are relatively effective for rhytid reduction, epidermal disruption or removal results in an open wound that places the patient at risk for bacterial, viral, and fungal infections. Abnormal or delayed wound healing may result in skin dyspigmentation and scarring. In addition, the wound resolves with significant erythema that often lasts for weeks or months and is cosmetically troubling to patients (Figure 1). The ideal method of skin rejuvenation would achieve optimal cosmetic improvement of photodamage while minimizing wound care and the risk of adverse effects.