The role of lasers and intense pulsed light technology in dermatology

Husain, Zain; Alster, Tina S.

doi:10.2147/ccid.s69106

Cited by 58 publications

(62 citation statements)

References 194 publications

(110 reference statements)

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“…IPL is wellabsorbed by cutaneous chromophores such as hemoglobin, melanin, and water molecules. Thus, IPL is effective in improving pigmented lesions, telangiectasias, and skin texture [2,3]. IR, poorly absorbed by the superficial chromophores, Min Jiang and Fang Yan contributed equally to this paper and are co-first author.…”

Section: Introductionmentioning

confidence: 99%

A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging

et al. 2017

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The clinical features of photoaging include: skin texture changes, laxity, rhytides, pigmentary changes, and vascular changes such as erythema and telangiectasias. In order to meet patients' increasing demands for improving all aspects of photoaging at one office visit, employing a multi-modality treatment for all aspects of photoaging has become increasingly desirable for the physician and patient alike. We examine a novel device that employs bipolar radiofrequency (RF), intense pulsed light (IPL), and infrared diode laser. These laser and light source treatments are performed sequentially. This study aims to evaluate the clinical efficacy and safety of this device (i.e., ELOS Triniti™). Twenty-six subjects received four ELOS Triniti™ treatments at 1-month intervals. They were followed up 1, 3, and 6 months after completing the treatments. Two blinded dermatologists used a comprehensive grading scale to evaluate the degree of the photoaging in terms of rhytides, laxity, dyschromia, erythema, telangiectasias, and texture. Subjects used a 0-10 grading scale for self-assessment of photoaging. Additionally, we measured the Erythema Index (EI), Melanin Index (MI), transepidermal water loss scores (TEWL), stratum corneum moisture scores (SC), and dermis moisture scores (D) before treatment and 1, 3, and 6 months after treatment. There was a statistically significant improvement in all five aspects of the comprehensive grading scale. Overall, it had excellent efficacy for improving erythema, telangiectasias, and skin texture. It also had a relatively long effect on improving skin laxity; however, it had only a limited ability to improve rhytides and dyschromia. It can mildly to moderately improve the global photoaging. This global effect can be noted 1 month after treatment and becomes most clinically apparent 3 months after treatment. This is maintained at least 6 months after treatment. MI index and SC and D values increased while EI index and TEWL values decreased after the treatment. The subjects' self-assessment improved by 2.7 ± 1.2 points. The overall satisfaction rate was 88%. The degree of pain measured 2.5 ± 1.9 points on average. There was no downtime and no severe side effects reported. The sequential implementation of bipolar radiofrequency based optical combination devices (IPL, IR, diode laser) is effective and safe for global facial photoaging.

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Section: Introductionmentioning

confidence: 99%

A prospective study of the safety and efficacy of a combined bipolar radiofrequency, intense pulsed light, and infrared diode laser treatment for global facial photoaging

et al. 2017

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“…PDL treatment caused the development of purpura due to extravasation of overheated erythrocytes in the dermis and associated with side effects, such as crusts, edema, depigmentation or hyperpigmentation due to deterioration of skin extravasal components. 20 Our data of the numerical simulation of the photothermal response of dysplastic vessels exposed to different laser irradiation showed the higher risk for the loss of selectivity in laser treatment with PDL irradiation to the smallest vessels due to the very high temperature of blood vessels. 21,22 It is of special value for the clinical application of PDL in the hemangioma infants treatment from the view of results of investigations performed in the framework of bench-bedside medicine.…”

Section: Discussionmentioning

confidence: 73%

Numerical Modeling and Clinical Evaluation of Pulsed Dye Laser and Copper Vapor Laser in Skin Vascular Lesions Treatment

2018

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Introduction: Different yellow lasers have been successfully used for the treatment of vascular lesions. This study is aimed to ascertain the role and efficiency of copper vapor lasers (CVLs) and pulsed dye lasers (PDLs) for the treatment of vascular lesions using numerical modeling and to compare results with our clinical experience. In this study we aimed to develop criteria for the choice of more efficient laser exposure mode, investigate more relevant modes of laser irradiation to ensure selective photothermolysis of target vessels, and compare the CVL and PDL efficiency in the course of patients with skin vascular lesions (SVL) treatment. Methods: We performed numerical simulation of the processes of heating a vessel with CVL and PDL to temperatures at which its coagulation could occur. Calculated fluencies were compared with clinical results of laser therapy performed on 1242 patients with skin hemangiomas and vascular malformations (SHVM), including 635 patients treated with CVL and 607 patients treated with PDL. PDL and CVL provided excellent results in 40 and ten days after treatment. The treatment was not painful. Patients did not need anesthesia. Postoperative crusts were greater with PDL than with CVL. Results: Results of computer simulation of a selective vessel heating using PDL and CVL radiation are presented. By results obtained, depth of the location and sizes of vessels that could be selectively heated to more than 75°C are determined. Conclusion: Based on calculated and clinical data, the heating mode for dysplastic vessels using a series of CVL micropulses could be regarded to be safer and more efficient than the mode of a PDL short, powerful pulse.

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“…To obtain a maximum effect, complementary therapies such as intralesional corticosteroids or 5-fluorouracil in case of resistant keloids can be added to these techniques. The numerous lasers types are subject to continuous development providing significant results in a wide range of skin conditions (10,11).…”

Section: Anothermentioning

confidence: 99%