Zur stimulierenden wirkung von arsenat auf den einbau von14C-thymidin in die DNA phytoh�magglutinin-behandelter menschlicher lymphocyten

Petres, J.; Baron, D.; Enderle, Janina

doi:10.1007/bf00562234

Cited by 7 publications

(2 citation statements)

References 35 publications

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“…It is, however, presumable that arsenic acts as an impediment to diverse enzyme-systems which interfere with nucleic acid metabolism, especially by interaction with those enzymes which contain sulfhydryl groups (8,(12)(13)(14). It is, however, presumable that arsenic acts as an impediment to diverse enzyme-systems which interfere with nucleic acid metabolism, especially by interaction with those enzymes which contain sulfhydryl groups (8,(12)(13)(14).…”

Section: Discussionmentioning

confidence: 99%

Effects of Arsenic Cell Metabolism and Cell Proliferation: Cytogenetic and Biochemical Studies

Petres¹,

Baron²,

Hagedorn³

1977

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) andBrogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives. Chromosome analysis of Iymphocytes from patients who had been exposed to arsenic showed frequent structural and numerical aberrations, even with an interval of decades since the last exposure.The in vitro addition of sodium arsenate induced the same chromosome changes-even to extreme of chromosome pulverizations-upon Iymphocyte cultures from healthy subjects. Radioactive incorporation studies showed that arsenate was able to inhibit dose-dependently the incorporation of radioactively labeled nucleotide in RNA and DNA. Beyond that, arsenic blocked the cells in the S-and G2-phase.A general explanation for the inhibitory effect of inorganic arsenic on cell metabolism is the known strong affinity of arsenic to enzymes, especially to those containing sulfllydryl groups.

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Section: Discussionmentioning

confidence: 99%

Effects of Arsenic Cell Metabolism and Cell Proliferation: Cytogenetic and Biochemical Studies

Petres¹,

Baron²,

Hagedorn³

1977

Environmental Health Perspectives

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show abstract

“…As III and As V inhibit DNA, RNA, and protein synthesis (Nakamuro and Sayato 1981) and replace phosphate in the nucleotides during DNA synthesis (Peters et al 1975). However, in contrast to other metal compounds such as those of nickel and chromium (which exhibit carcinogenic properties), arsenicals do not affect the fidelity of the polymerases involved in the biosynthesis of DNA (Tkeshelashvilli et al 1980), but apparently seriously affect repair systems (Abernathy et al 1999).…”

Section: Mutagenic Effectsmentioning

confidence: 99%