We investigated the influence of various nonoccupational factors on blood lead levels (PbB) in a sample from the general population of southern Germany. Some 1703 men and 1661 women, aged 28-67 years, were examined in the first follow-up examination of the MONICA Augsburg cohort study in 1987-1988. Their mean PbB was 90 micrograms/l (SD:35.9) for men and 65 micrograms/l (26.4) for women. Only 5% of the men and 1% of all women exceeded a PbB level of 150 micrograms/l indicating low-level lead exposure in this population. Blood lead was significantly associated with haematocrit values (P < 0.001) and the shape of this association was curvilinear. Per gram of alcohol consumed, intake of beer had a lower impact on PbB than wine, presumably due to differential lead content in these alcoholic beverages. The alcohol-PbB associations were stronger for women than for men. The impact of smoking was generally moderate but again more prominent in women. In particular, the covariate adjusted odds ratios for women of childbearing age (28-47 years) to have PbB levels above 100 micrograms/l were 2.5 (95% confidence interval (CI): 1.3-4.7) for smoking versus non-smoking females, 2.6 (95% CI: 1.1-6.0) for women drinking up to 40 g alcohol/day compared to abstainers, and 8.9 (95% CI: 3.2-25.1) for those drinking more than 40 g alcohol/day. Other factors like age, body mass, rural place of residence, and education or job position, had only minor influences on PbB. We conclude that haematocrit values should always be considered as potential confounders in low-level lead exposure research. High alcohol consumption and cigarette smoking are strongly related to elevated blood lead concentrations in the general population and may thereby convey additional health hazards such as impaired child development or blood pressure elevations. This deserves proper public health recognition [corrected].

h simple, rapid method is described for the determination of lead in whole blood by means of electrothermal atomic-absorption spectrophotometry. Aliquots (25-200 pl) of fingerprick and venous samples were treated with 2 M nitric acid for deproteinisation and matrix modification. After centrifuging, the supernatant was taken for the automated analysis for lead. The accuracy of the method was checked with independent methods and found to be satisfactory. Thus it was established that the accuracy obtainable of <30% lies almost within the confidence intervals ( p = 0.05) of precision.An evaluation of 282 pairs of randomly selected routine samples indicated an acceptable precision : the relative standard deviation for, for example, the normal level of 100 pg 1-1 is 8.4Oj,, and for an elevated level of 480 pg 1-1 is 3.47%. The shortened temperature programme makes up to 370 measurements per day possible and the computer coupling permits an immediate data evaluation during occupational and screening programmes and makes possible round-the-clock measurements.

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Urinary excretion of lead (Pb) was measured in the basal state and following the infusion of EDTA (1 g of calcium disodium edetate) in healthy German controls and in patients with chronic renal failure with and without gout. When evaluated with Zeeman-compensated atomic absorption spectroscopy using the L’vov platform and urine pretreated with nitric acid and Triton X-100, the control basal Pb excretion (median 28, range 11–19 nmol Pb/24 h) and the postinfusion Pb increment (306, range 131–1,587 nmol/4 days/1.73 m²) were considerably lower than most values reported previously in the literature. Elevated Pb body burden was found in 7 of 8 patients who developed gout in the course of renal failure, but only in 2 of 8 patients who had gout prior to development of renal failure; this confirms that appearance of gout in patients with renal failure points to prior Pb exposure. In 7 of 19 nongouty patients with impaired renal function secondary to known renal diseases, urinary Pb excretion was above the 95th percentile of normal. All these patients had occupational Pb exposure. The high prevalence of elevated Pb body burden in patients with renal failure of known cause may not be coincidental and raises the possibility that Pb adversely affects the course of renal disease.

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