Effects of Arsenic Cell Metabolism and Cell Proliferation: Cytogenetic and Biochemical Studies

Abstract

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A New Method for the Analysis of Cohort Studies: Implications of the Multistage Theory of Carcinogenesis Applied to Occupational Arsenic Exposure

“…(cohort continuously exposed to arsenic) 30 For individuals whose exposure had stopped, i.e., those who terminated their employment, the multistage theory predicts that their excess cancer risk after cessation of employment will be an increasing function of exposure duration and concentration, and will also be independent of age started exposure (if only the first stage is affected) or follow-up time since exposure stopped (if only the penultimate stage is affected). The indirect adjustment method was applied to the data in Table 4 to produce excess lung cancer mortality rates for each of these four factors adjusted for the possible confounding effects of the other three factors.…”

The Carcinogenicity of Arsenic

“…Incorporation of radioactively labelled nucleotides in dermal cells and lymphocytes was reduced by sodium arsenate (84,85). Incorporation of radioactively labelled nucleotides in dermal cells and lymphocytes was reduced by sodium arsenate (84,85).…”

“…An increased frequency of chromosomal aberrations has been observed among workers exposed to inorganic arsenic compounds, as well as in patients who had taken drugs containing arsenic (85,89). Chromosomal aberrations have also been produced 96 Environmental Health Perspectives in vitro by inorganic arsenic salts (90,91).…”

Occupational and environmental risks in and around a smelter in northern Sweden VII. Reanalysis and follow-up of chromosomal aberrations in workers exposed to arsenic

“…PETRES et al (1970PETRES et al ( , 1977 found increased frequencies of chromosomal aberrations in psoriatic patients treated therapeutically with arsenic and in wine growers exposed to arsenic-containing pesticides. PETRES et al (1970PETRES et al ( , 1977 found increased frequencies of chromosomal aberrations in psoriatic patients treated therapeutically with arsenic and in wine growers exposed to arsenic-containing pesticides.…”