Zolpidem test and catatonia

Javelot, Hervé; Michel, Bruno; Steiner, Riccardo; Javelot, Thierry; Cottencin, Olivier

doi:10.1111/jcpt.12330

Cited by 13 publications

(9 citation statements)

References 15 publications

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“…To this day, benzodiazepines remain the first-line treatment for catatonic patients, albeit significantly less effective in cases of schizophrenic catatonia compared to mood disorder-related catatonia (60% and over 90% response rates, respectively [2,12]). Other GABA-A agonists such as zolpidem have also been studied with encouraging results [6] and even in order to make a diagnosis test [28]. In case of partial or nonresponse to lorazepam treatment, ECT appears to be the treatment of choice [7,8] with a high efficacy, although also significantly lower among patients with schizophrenia diagnosis with respect to other pathologies [2].…”

Section: Discussionmentioning

confidence: 99%

Lorazepam-Resistant Catatonia in an Antipsychotic-Naïve 24-Year-Old with Psychotic Symptoms

Lucchelli

Kourakou

Bové

et al. 2020

Case Reports in Psychiatry

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Catatonia is a complex identifiable clinical syndrome characterized primarily by psychomotor symptoms. In recent decades, some authors have considered that catatonia can be presented as a catatonic syndrome in several pathologies such as bipolar disorder, schizophrenia and other psychotic disorders and not only in schizophrenia. Prior to DSM 5, there were two conceptions of catatonia: one in which clinical characterization seemed to play a determining role (a categorical view) and another in which a dimensional perspective advocated the existence of catatonia as a clinical entity in its own right, detached from the underlying pathology. Although there are no definitive consensus guidelines for the treatment of catatonia, some studies show that in the schizophrenic form of catatonia, benzodiazepines are partially effective, as well as treatment with ECT. We present the case of a 24-year-old man with severe catatonia and psychotic symptoms, resistant to lorazepam treatment, who achieved complete remission with clozapine treatment according to our diagnostic hypothesis of schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Lorazepam-Resistant Catatonia in an Antipsychotic-Naïve 24-Year-Old with Psychotic Symptoms

Lucchelli

Kourakou

Bové

et al. 2020

Case Reports in Psychiatry

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“…Also, the problematic of the diagnosis also puts pressure on the therapeutic conduct, the patient being subjected to a complex therapeutic association, after which the remission was obtained. In the literature, Zolpidem has shown its role in improving the symptoms of catatonia, with numerous studies mentioning it (6,7,8,11,12,13), thus leading to the creation of a "Response test" therapeutically " (9,10).…”

Section: Discussionmentioning

confidence: 99%

Catatonic syndrome – positive and differential diagnostic controversies. Case study

Aniculăesei¹,

Radu²,

Boloș³

et al. 2019

BPI

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The present paper is the presentation of a case that exposes a positive and differential diagnosis controversy, in the context of a catatonic syndrome with a sudden onset, occurring in an apparent state of mental health, in a patient of 42 years old, without personal or heredocolateral psychiatric history, with normal premorbid functioning. Its purpose is to emphasize the importance of excluding organicity in the case of catatonic syndrome and to make it aware that the impact of the often impressive psychotic symptoms should not overshadow the detection of potentially life-threatening somatic symptoms. The presented case underlines precisely the dilemma of establishing the etiology of catatonic syndrome, between endogenous causes and underdiagnosed meningeal reaction.

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“…There is no guidance for the clinician on how to proceed after benzodiazepines and ECT have failed. Based on CATATONIA, AKATHISIA AND DYSKINESIA some case reports, the use of zolpidem (Mastain et al, 1995;Javelot et al, 2015;Amorim and McDade, 2016) or lorazepam in a very high dosage (28 mg/day) (van der Markt et al, 2015) is advised. Based on pathophysiology, several hypothetical approaches have been proposed, such as oxytocin (because of its impact on fear and anxiety as it acts on the amygdala) (Ellul and Choucha, 2015) or GABAergic-glutamatergic drugs such as acamprosate and lamotrigine (Ellul and Choucha, 2015).…”

Section: Resistant Catatoniamentioning

confidence: 99%

The psychopharmacology of catatonia, neuroleptic malignant syndrome, akathisia, tardive dyskinesia, and dystonia

Sienaert

Harten

Rhebergen³

2019

Handbook of Clinical Neurology

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Zolpidem test and catatonia

Abstract: Zolpidem with appropriate testing appears to be a credible alternative to electroconvulsive therapy or increased lorazepam dosing and allows continuation of antipsychotic administration.

Cited by 13 publications

References 15 publications

Lorazepam-Resistant Catatonia in an Antipsychotic-Naïve 24-Year-Old with Psychotic Symptoms

Lorazepam-Resistant Catatonia in an Antipsychotic-Naïve 24-Year-Old with Psychotic Symptoms

Catatonic syndrome – positive and differential diagnostic controversies. Case study

The psychopharmacology of catatonia, neuroleptic malignant syndrome, akathisia, tardive dyskinesia, and dystonia

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