ZnO nanoparticles attenuate polymer-wear-particle induced inflammatory osteolysis by regulating the MEK-ERK-COX-2 axis

Meng, Xiangchao; Zhang, Wei; Lyu, Zhuocheng; Long, Teng; Wang, You

doi:10.1016/j.jot.2022.04.001

Cited by 13 publications

(9 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In summary, graphene particles could inhibit the secretion of pro-inflammatory factors (IL-6, IL-1, and TNF-α) from macrophage, upregulate the secretion of anti-inflammatory factors (IL-4 and IL-10) from macrophage, and further suppress inflammation. This might be because GNPs might reduce inflammatory osteolysis by inhibiting the MAPK/ERK kinase1/2 pathway . ECPP particles have same trend in suppressing inflammatory respond.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Modulating both inflammation and stem cells by designing an artificial joint material to obtain the continuous prevention and control on aseptic loosening (AL) is a novel strategy. In this paper, graphene/europium-doped calcium polyphosphate (GNPs/ECPP) particles were obtained by ultrasound method and spark plasma sintering (SPS) method. The prepared particles were used to modulate the inflammatory response and further obtain cascade regulation on the proliferation, recruitment, and differentiation of stem cells. The results showed that particles obtained by SPS had a stronger effect on promoting the proliferation and differentiation of stem cells, while by ultrasound method more stem cells were recruited. Besides, the graphene and Eu3+ contained in the particles obtained by SPS method could effectively play a synergistic role on the differentiation of stem cells. In vivo experiment results demonstrated that the composite particles effectively suppress the inflammatory response, recruit stem cells, and prevent AL by inhibiting the secretion of inflammatory factors.

show abstract

Section: Resultsmentioning

confidence: 99%

“…This might be because GNPs might reduce inflammatory osteolysis by inhibiting the MAPK/ERK kinase1/2 pathway. 48 ECPP particles have same trend in suppressing inflammatory respond. Compared with CPP particles, the effects of ECPP particles on inflammation rely on the release of Eu 3+ .…”

Section: Characterization Of Particlesmentioning

confidence: 89%

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Lei

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…Osteoclasts play a central role in forming and regulating bone mass and are the main resorbing cells of bone (Boyce, 2013;Meng et al, 2022). The initial process of bone resorption is the attachment of osteoclasts to the bone matrix, resulting in polarization followed by a fold of the cytoplasm and membrane into the ruffled edge, which attaches to the bone surface and secretes H+ through the proton pump on the ruffled edge (Takayanagi, 2021).…”

Section: Discussionmentioning

confidence: 99%

Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis

Li²,

Chen³

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

A major complication of a joint replacement is prosthesis loosening caused by inflammatory osteolysis, leading to the revision of the operation. This is due to the abnormal activation of osteoclast differentiation and function caused by periprosthetic infection. Therefore, targeting abnormally activated osteoclasts is still effective for treating osteolytic inflammatory diseases. CDZ173 is a selective PI3K inhibitor widely used in autoimmune-related diseases and inflammatory diseases and is currently under clinical development. However, the role and mechanism of CDZ173 in osteoclast-related bone metabolism remain unclear. The possibility for treating aseptic prosthesis loosening brought on by inflammatory osteolysis illness can be assessed using an LPS-induced mouse cranial calcium osteolysis model. In this study, we report for the first time that CDZ173 has a protective effect on LPS-induced osteolysis. The data show that this protective effect is due to CDZ173 inhibiting the activation of osteoclasts in vivo. Meanwhile, our result demonstrated that CDZ173 had a significant inhibitory effect on RANKL-induced osteoclasts. Furthermore, using the hydroxyapatite resorption pit assay and podosol actin belt staining, respectively, the inhibitory impact of CDZ173 on bone resorption and osteoclast fusion of pre-OC was determined. In addition, staining with alkaline phosphatase (ALP) and alizarin red (AR) revealed that CDZ173 had no effect on osteoblast development in vitro. Lastly, CDZ173 inhibited the differentiation and function of osteoclasts by weakening the signal axis of PI3K-AKT/MAPK-NFATc1 in osteoclasts. In conclusion, our results highlight the potential pharmacological role of CDZ173 in preventing osteoclast-mediated inflammatory osteolysis and its potential clinical application.

show abstract

“…85 In addition, it has been demonstrated that the addition of ZnO significantly enhances the anti-wear properties of PEEK and reduces polymer wear particle-induced inflammation and osteolysis by modulating the MEK-ERK-COX-2 axis. 86,87 Sr is also an important trace element in the body and plays a dual role in bone metabolism, inhibiting bone resorption and stimulating bone formation. Sr + -modified PEEK has been shown to have multiple functions in osteogenesis, anti-inflammation and angiogenesis.…”

Section: Bioactive Materials Modified Peekmentioning

confidence: 99%

Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Huang,

Liu,

Wang

et al. 2024

J. Mater. Chem. B

View full text Add to dashboard Cite

show abstract

ZnO nanoparticles attenuate polymer-wear-particle induced inflammatory osteolysis by regulating the MEK-ERK-COX-2 axis

Cited by 13 publications

References 47 publications

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo

Phosphatidyl Inositol 3-Kinase (PI3K)-Inhibitor CDZ173 protects against LPS-induced osteolysis

Strategies to improve the performance of polyetheretherketone (PEEK) as orthopedic implants: from surface modification to addition of bioactive materials

Contact Info

Product

Resources

About