Cascade Regulation of the Proliferation, Recruitment, and Differentiation of Stem Cells to Prevent Aseptic Loosening by GNPs/ECPP Particles Responding to Macrophages: In Vitro and In Vivo
Abstract:Modulating both inflammation and stem cells by designing
an artificial
joint material to obtain the continuous prevention and control on
aseptic loosening (AL) is a novel strategy. In this paper, graphene/europium-doped
calcium polyphosphate (GNPs/ECPP) particles were obtained by ultrasound
method and spark plasma sintering (SPS) method. The prepared particles
were used to modulate the inflammatory response and further obtain
cascade regulation on the proliferation, recruitment, and differentiation
of stem cel… Show more
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