Bone tissue regeneration is still a major orthopedic challenge. The process of bone regeneration is often disrupted by inflammation. Elevated levels of reactive oxygen species (ROS) can lead to aggravated...
Bone regeneration in large bone defects remains one of the major challenges in orthopedic surgery. Calcium polyphosphate (CPP) scaffolds possess excellent biocompatibility and exhibits good bone ingrowth. However, the present CPP scaffolds lack enough osteoinductive activity to facilitate bone regeneration at bone defects that exceed the critical size threshold. To endow CPP scaffolds with improved osteoinductive activity for better bone regeneration, in this study, a self-assembled coating with chitosan-grafted reduced graphene oxide (CS-rGO) sheets was successfully constructed onto the surface of CPP scaffolds through strong electrostatic interaction and hydrogen bonds. Our results showed that the obtained CPP/CS-rGO composite scaffolds exhibited highly improved biomineralization and considerable antibacterial activity. More importantly, CPP/CS-rGO composite scaffolds could drive osteogenic differentiation of BMSCs and significantly up-regulate the expression of osteogenesis-related proteins in vitro. Meanwhile, the CS-rGO coating could inhibit aseptic loosening and improve interfacial osseointegration through stimulating BMSCs to secrete more OPG and lesser RANKL. Overall, the CS-rGO coating adjusts CPP scaffolds’ biological environment interface and endows CPP scaffolds with more bioactivity.
The synergistic strategy of sulfonated, oxidized pectin and quercetin can enhance the BVLs’ mechanical properties and also endow BVLs with excellent hemocompatibility, anti-inflammatory, anti-calcification, and pro-endothelialization.
Modulating both inflammation and stem cells by designing
an artificial
joint material to obtain the continuous prevention and control on
aseptic loosening (AL) is a novel strategy. In this paper, graphene/europium-doped
calcium polyphosphate (GNPs/ECPP) particles were obtained by ultrasound
method and spark plasma sintering (SPS) method. The prepared particles
were used to modulate the inflammatory response and further obtain
cascade regulation on the proliferation, recruitment, and differentiation
of stem cells. The results showed that particles obtained by SPS had
a stronger effect on promoting the proliferation and differentiation
of stem cells, while by ultrasound method more stem cells were recruited.
Besides, the graphene and Eu3+ contained in the particles
obtained by SPS method could effectively play a synergistic role on
the differentiation of stem cells. In vivo experiment
results demonstrated that the composite particles effectively suppress
the inflammatory response, recruit stem cells, and prevent AL by inhibiting
the secretion of inflammatory factors.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.