ZnO Nanoparticle-Catalyzed Multicomponent Reaction for the Synthesis of 1,4-Diaryl Dihydropyridines

Reen, Gagandeep Kour; Ahuja, Monika; Kumar, Ashok; Patidar, Rajesh; Sharma, Pratibha

doi:10.1080/00304948.2017.1320927

Cited by 22 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another route towards the synthesis of dihydropyridines using nano zinc oxide catalyst was developed . One‐pot solvent‐free reaction of aromatic aldehydes, aromatic amines and

β

‐dicarbonyls using 15 mol % nano ZnO at 80 °C, produced various 1,4‐DHPs (1,4‐dihydropyridines) in good yields (Scheme ).…”

Section: Heterocyclic Compoundsmentioning

confidence: 99%

Zinc‐Catalysed Multi‐Component Reactions: An Overview

Neetha¹,

Rohit²,

Saranya³

et al. 2020

ChemistrySelect

View full text Add to dashboard Cite

Multi-component reactions (MCRs) have gathered much attention recently due to their superior efficiency, exceptional selectivity and simplicity. Synthesis of various compounds with maximum efficiency and almost zero by-products are their major highlights. Zinc is an easily accessible, economically feasible and environmentally viable catalyst. This first review in this topic focuses on the developments in zinc-catalysed multicomponent reactions and covers literature up to 2019.

show abstract

“…Another route towards the synthesis of dihydropyridines using nano zinc oxide catalyst was developed . One‐pot solvent‐free reaction of aromatic aldehydes, aromatic amines and

β

‐dicarbonyls using 15 mol % nano ZnO at 80 °C, produced various 1,4‐DHPs (1,4‐dihydropyridines) in good yields (Scheme ).…”

Section: Heterocyclic Compoundsmentioning

confidence: 99%

Zinc‐Catalysed Multi‐Component Reactions: An Overview

Neetha¹,

Rohit²,

Saranya³

et al. 2020

ChemistrySelect

View full text Add to dashboard Cite

show abstract

“…[24] Also, despite the diversified advantages associated with carbon nanotubes, its use as a catalyst is hitherto unrivaled, although this can leads to the expedient synthesis of imidazo fused benzothiazole scaffolds. On keeping these observations in mind and continuation of our interest toward nanocatalysis, [25][26][27][28][29] we propose an alternative eco-friendly synthetic methodology for the synthesis of highly functionalized benzo[d]imidazo [1,2-b]thiazoles using multiwall carbon nanotubes mediated with nickelferrite magnetic nanoparticles (NiFe 2 O 4 -CNTs), as an efficacious, economical and noncorrosive heterogeneous catalyst, under aerobic conditions via. A 3 coupling followed by 5-exo-dig cyclization.…”

Section: Introductionmentioning

confidence: 99%

Multiwalled carbon nanotubes crowned with nickel‐ferrite magnetic nanoparticles assisted heterogeneous catalytic strategy for the synthesis of benzo[d]imidazo[2,1‐b]thiazole scaffolds

Geedkar

Kumar

Sharma

2020

Journal of Heterocyclic Chem

Self Cite

View full text Add to dashboard Cite

Present manuscript elicits an account of the sonication promoted multicomponent reactions strategy assisted by multiwalled carbon nanotubes embraced with nickel-ferrite (NiFe 2 O 4-CNTs) magnetic nanoparticles, as a heterogeneous catalyst to synthesize a novel series of pharmacologically active benzo[d]imidazo[2,1-b]thiazole scaffolds. The synthesis of these biologically active derivatives was achieved via. A 3 coupling involving 2-aminoben zothiazole, pertinent aryl aldehydes and phenyl acetylene derivatives, proceeded in PEG 400 as green solvent under aerobic conditions to afford the products in good to excellent yields. The higher environmental compatibility and sustainability factors such as higher ecoscale score, smaller E-factor and appreciable atom economy put this etiquette under the parasol of green chemistry precepts. The characterization of synthesized catalysts was attained through varied techniques viz. powder X-ray diffraction, field emission scanning electron microscopy with energy-dispersive X-ray spectroscopy, Raman, FT-IR, VSM and TGA-DTA-DTG analyses, dispersion studies, and nitrogen porosimetry analyses. The structures of the synthesized compounds were also endorsed by extensive spectroscopic studies (FT-IR, 1 H and 13 C NMR, Mass) and elemental analyses.

show abstract

“…Recently, A 3 coupling of alkynes, aldehydes, and aminopyridines have been developed for efficient syntheses of IPs [20]. In recent years much attention has been paid towards the exploration of transition metals (TMs) as homogeneous as well as heterogeneous catalytic system like Pd(OAc) 2 [21], CuI [22], ZnO [23], ZnI 2 [24], Cu(OTf) 2 [25], Sc(OTf) 3 [26], RuCl 3 [27], [Cp * RhCl 2 ] 2 (Cp * : pentamethylcyclopentadiene) [28], FeCl 3 [29], NiFe 2 O 4 [30], CuO [31], mixed-metal oxides [32] etc. Some of the reactions have utilized metal salts like Cu(OAc) 2 , Ag 2 CO 3 , AgOAc, etc.…”

Section: Introductionmentioning

confidence: 99%

“…Zinc salts being inexpensive, environmentally benign, low in toxicity and fits to the tenets of green chemistry. Zinc in the form of its salts, complexes (chelated by mono/di/tri/tetradentate ligands), oxides and sulfides proved to be a promising and active catalyst for organic chemists in both homogeneous as well as heterogeneous reaction systems [23,59–60]. They have been employed for a number of organic reactions viz., hydrosilylation of aldehydes and ketones, acetylation reactions, redox reactions, oxidative esterification, etc.…”

Section: Introductionmentioning

confidence: 99%

Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage

Reen

Kumar

Sharma

2019

Beilstein J. Org. Chem.

Self Cite

View full text Add to dashboard Cite

A comprehensive account of recent advances in the synthesis of imidazopyridines, assisted through transition-metal-catalyzed multicomponent reactions, C–H activation/functionalization and coupling reactions are highlighted in this review article. The basic illustration of this review comprises of schemes with concise account of explanatory text. The schemes depict the reaction conditions along with a quick look into the mechanism involved to render a deep understanding of the catalytic role. At some instances optimizations of certain features have been illustrated through tables, i.e., selectivity of catalyst, loading of the catalyst and percentage yield with different substrates. Each of the reported examples has been rigorously analyzed for reacting substrates, reaction conditions and transition metals used as the catalyst. This review will be helpful to the chemists in understanding the challenges associated with the reported methods as well as the future possibilities, both in the choice of substrates and catalysts. This review would be quite appealing to a wider range of organic chemists in academia and industrial R&D sectors working in the field of heterocyclic syntheses. In a nutshell, this review will be a guiding torch to envisage: (i) the role of various transition metals in the domain dedicated towards method development and (ii) for the modifications needed thereof in the R&D sector.

show abstract

ZnO Nanoparticle-Catalyzed Multicomponent Reaction for the Synthesis of 1,4-Diaryl Dihydropyridines

Cited by 22 publications

References 46 publications

Zinc‐Catalysed Multi‐Component Reactions: An Overview

Zinc‐Catalysed Multi‐Component Reactions: An Overview

Multiwalled carbon nanotubes crowned with nickel‐ferrite magnetic nanoparticles assisted heterogeneous catalytic strategy for the synthesis of benzo[d]imidazo[2,1‐b]thiazole scaffolds

Recent advances on the transition-metal-catalyzed synthesis of imidazopyridines: an updated coverage

Contact Info

Product

Resources

About