Zinc‐Catalysed Multi‐Component Reactions: An Overview

Neetha, Mohan; Rohit, K.; Saranya, Salim; Anilkumar, Gopinathan

doi:10.1002/slct.201904146

Cited by 21 publications

(15 citation statements)

References 80 publications

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“…Hantzsch dihydropyridine synthesis, [ 6,7 ] Biginelli reaction, [ 8,9 ] Passerini reaction, [ 10,11 ] Kabachnik‐Fields reaction, [ 12,13 ] Ugi reaction, [ 14,15 ] Gröbcke‐Blackburn‐Bienaymé reaction [ 16 ] etc. Transition metal catalysis also made its way into multicomponent reactions and different transition metals like Pd, [ 17 ] Cu, [ 18,19 ] Rh, [ 20 ] Au, [ 21 ] Ag, [ 22 ] Zn, [ 23 ] Fe [ 24,25 ] etc. have shown its applicability in MCRs.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the iron‐catalysed multicomponent reactions

Saranya

Aneeja

Neetha

et al. 2020

Applied Organom Chemis

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Iron‐catalysed reactions are widely used in organic synthesis owing to its benefits over other metals. Among the important organic reactions, multicomponent reactions play a significant role due to its greener aspects like high atom economy, minimal amount of by‐product, economic feasibility etc. For the past few years, iron‐catalysed multicomponent reactions have attracted the attention of several chemists which lead to the invention of some fine chemistry. The majority of iron‐catalysed multicomponent reactions results in the synthesis of heterocyclic compounds having biologically active natural products, pharmaceutical etc. These developments in the iron‐catalysed multicomponent reactions are the focus of this review. This is the first review in this topic which covers the literature up to 2020, and it encompasses the different methods for the synthesis of acyclic, carbocyclic and heterocyclic compounds.

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Section: Introductionmentioning

confidence: 99%

Recent advances in the iron‐catalysed multicomponent reactions

Saranya

Aneeja

Neetha

et al. 2020

Applied Organom Chemis

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“…Lewis acids have been known as one of the best options regarding catalytic MCRs. [ 86–88 ] Their selection provides relative stability, ease of handling, low cost and high yields. The importance of Lewis acids as catalysts in synthetic organic chemistry originates from the fact that they are capable of coordinating with carbonyl groups and other oxygen atoms, nitrogen containing functional groups, while being used in catalytic amounts.…”

Section: Scope and Limitationsmentioning

confidence: 99%

The Ugi Three‐Component Reaction; a Valuable Tool in Modern Organic Synthesis

2020

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The Ugi three component reaction (U‐3CR) is a variation of the famous Ugi reaction, discovered almost 60 years ago. Today it is somehow neglected, compared to the classical variation, although the α‐aminoamides, derived from this reaction, have been utilized as inhibitors for various targets and even commercial drugs, offering improved pharmacokinetic properties. In this review, we are describing the scope and limitations of the reaction with a special focus on the developed catalytic protocols, the bioactive compounds, and drugs which are based on the reaction and finally the post modifications that have been reported in order to access drug‐like and privileged scaffolds. A special focus is given to the 3D solid state conformations of the U‐3CR derivatives.

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“…Multicomponent reactions reflect also the state of the art in chemical control since generally C-C and C-X (X = heteroatom) bonds are formed in one single step. For recent interesting applications of mechanochemistry in multicomponent reactions see references [ 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 ].…”

Section: Mechanochemistrymentioning

confidence: 99%

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

Avila‐Ortiz

Juaristi

2020

Molecules

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One central challenge for XXI century chemists is the development of sustainable processes that do not represent a risk either to humanity or to the environment. In this regard, the search for more efficient and clean alternatives to achieve the chemical activation of molecules involved in chemical transformations has played a prominent role in recent years. The use of microwave or UV-Vis light irradiation, and mechanochemical activation is already widespread in many laboratories. Nevertheless, an additional condition to achieve “green” processes comes from the point of view of so-called atom economy. The removal of solvents from chemical reactions generally leads to cleaner, more efficient and more economical processes. This review presents several illustrative applications of the use of sustainable protocols in the synthesis of organic compounds under solvent-free reaction conditions.

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Zinc‐Catalysed Multi‐Component Reactions: An Overview

Cited by 21 publications

References 80 publications

Recent advances in the iron‐catalysed multicomponent reactions

Recent advances in the iron‐catalysed multicomponent reactions

The Ugi Three‐Component Reaction; a Valuable Tool in Modern Organic Synthesis

Novel Methodologies for Chemical Activation in Organic Synthesis under Solvent-Free Reaction Conditions

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