Zn-MOF hydrogel: regulation of ROS-mediated inflammatory microenvironment for treatment of atopic dermatitis

Abstract

Atopic dermatitis (AD) is a chronic and recurrent inflammation disease associated with immune dysfunction. The high level of reactive oxygen species (ROS) causes high oxidative stress and further results in the deterioration of AD. At the same time, the ROS produced by bacterial infection can further aggravate AD. Here, the prepared PVA-based hydrogel (Gel) has a high ROS scavenging ability, and the antibacterial agent Zn-MOF(ZIF-8) loaded into the hydrogel shows a lasting and effective antibacterial activity. Thus, a Zn-MOF hydrogel (Gel@ZIF-8) is prepared to regulate ROS-mediated inflammatory microenvironment. In vitro experiments show that Gel@ZIF-8 has good antibacterial effect and cell biocompatibility. In the AD-induced mouse model, Gel@ZIF-8 can significantly enhance the therapeutic effect, such as reduce the thickness of epidermis, the number of mast cells and IgE antibodies. The results indicate that the ROS-scavenging hydrogel could treat the AD by regulating the inflammatory microenvironment, providing a promising treatment for managing AD.

Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

“…Scale bars, 100 μm. q Relative quantification of mast cells [ 239 ]. Copyright 2023, Springer Nature …”

“…Therefore, an effective approach for managing AD also involves the elimination of microbes and regulation of oxidative stress on the skin surface [ 233 ]. To address this issue, a recent study led by Qiu et al developed a hydrogel incorporating ZIF-8, referred to as Gel@ZIF-8 [ 239 ]. This hydrogel demonstrated remarkable ROS responsiveness, antibacterial effects, and high biocompatibility (Fig.…”

Signaling Pathways Triggering Therapeutic Hydrogels in Promoting Chronic Wound Healing

“…Inorganic metal nanoparticles (NPs), such as silver (Ag), zinc(Zn), and copper (Cu), have been integrated into hydrogels to develop antibacterial biomaterials. [58][59][60][61] The bactericidal mechanism of metal ions is primarily attributed to their denaturing effect on bacterial proteins, rendering them effective for broad-spectrum bacterial control with minimal risk of drugresistant strains. Among these, silver (Ag) is widely employed as an antimicrobial agent, often incorporated as a physical coating within hydrogel systems.…”

ZIF-8/Curcumin-Loaded Electrospun Nanofiber Membrane for Wound Healing

“…Notably, when ZIF-8 disintegrates, it continuously releases Zn 2+ , which is an excellent antibacterial agent. Numerous studies have demonstrated that using the original ZIF-8 or nanocomposites based on ZIF-8 may prevent bacterial invasion and facilitate pathogen removal, thereby preventing bacterial infection during the wound-healing process. − However, ZIF-8 is typically obtained in the form of a fragile microcrystalline powder, which limits its applicability to use as a dressing for treating skin wounds.…”