ZIF-8/Curcumin-Loaded Electrospun Nanofiber Membrane for Wound Healing
Chen Hang,
Zhou Wei,
Xiang Jieyu
et al.
Abstract:Conventional clinical dressings have limited antibacterial,
anti-inflammatory,
and antioxidant activities and are unable to maintain moisture in
wounds. To overcome the aforementioned limitations of conventional
medical materials, it is urgent to develop multifunctional materials
that can accelerate wound healing in clinical practice. In this study,
a composite of polycaprolactone (PCL) and curcumin-incorporated zeolitic
imidazolate framework-8 (denoted as PCL/ZIF-8/CUR) was prepared by
using a seed-free soaki… Show more
“…The water contact angle results revealed that incorporation of drug-loaded MOFs throughout the polycaprolactone significantly improved hydrophilicity stemming from the high content of hydroxyl groups on the MOF nanoparticles which increased polarity of the polymer matrix. [174] Zinc imidazolate frameworks were grown into chitin sponges in situ to yield an effective hemostasis and antibacterial wound dressing. The nanocrystals were not only distributed homogenously all over the sponge, but also got anchored firmly on the sponge (Figure 13).…”
Section: Enhanced Moisture Management With Mofsmentioning
In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds and antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of materials for next‐generation wound healing and dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, and potential for combination therapies make them suitable for complex wound care challenges. MOF‐based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal therapies for skin cancer and infections. Herein, a critical analysis of the current state of research on MOFs and MOF‐based composites for wound healing and dressings is provided, offering valuable insights into the potential applications, challenges, and future directions in this field. This literature review has targeted the multifunctionality nature of MOFs in wound‐disease therapy and healing from different aspects and discussed the most recent advancements made in the field. In this context, the potential reader will find how the MOFs contributed to this field to yield more effective, functional, and innovative dressings and how they lead to the next generation of biomaterials for skin therapy and regeneration.
“…The water contact angle results revealed that incorporation of drug-loaded MOFs throughout the polycaprolactone significantly improved hydrophilicity stemming from the high content of hydroxyl groups on the MOF nanoparticles which increased polarity of the polymer matrix. [174] Zinc imidazolate frameworks were grown into chitin sponges in situ to yield an effective hemostasis and antibacterial wound dressing. The nanocrystals were not only distributed homogenously all over the sponge, but also got anchored firmly on the sponge (Figure 13).…”
Section: Enhanced Moisture Management With Mofsmentioning
In recent years, there has been growing interest in developing innovative materials and therapeutic strategies to enhance wound healing outcomes, especially for chronic wounds and antimicrobial resistance. Metal–organic frameworks (MOFs) represent a promising class of materials for next‐generation wound healing and dressings. Their high surface area, pore structures, stimuli‐responsiveness, antibacterial properties, biocompatibility, and potential for combination therapies make them suitable for complex wound care challenges. MOF‐based composites promote cell proliferation, angiogenesis, and matrix synthesis, acting as carriers for bioactive molecules and promoting tissue regeneration. They also have stimuli‐responsivity, enabling photothermal therapies for skin cancer and infections. Herein, a critical analysis of the current state of research on MOFs and MOF‐based composites for wound healing and dressings is provided, offering valuable insights into the potential applications, challenges, and future directions in this field. This literature review has targeted the multifunctionality nature of MOFs in wound‐disease therapy and healing from different aspects and discussed the most recent advancements made in the field. In this context, the potential reader will find how the MOFs contributed to this field to yield more effective, functional, and innovative dressings and how they lead to the next generation of biomaterials for skin therapy and regeneration.
Skin infections are major threat to human health. Early diagnosis of bacterial infections is of great significance for implementing protective measures on the skin. Therefore, in this study, we designed...
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