Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Abstract

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients and the healthcare system. Conventional therapies, such as corticosteroids and nonsteroidal anti-inflammatory drugs, are limited in efficacy and associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise in addressing these challenges. NZ-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of hydrogels. The multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and differentiation. This review highlights the current state of the art in NZ-engineered hydrogels (NZ@hydrogels) for anti-inflammatory and skin regeneration applications. It also discusses the underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, the challenges and future directions in this ground, particularly their clinical translation, are addressed. The insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels, offering new possibilities for targeted and personalized skin-care therapies.

Electrospun organic/inorganic hybrid nanofibers for accelerating wound healing: a review

“…6 However, these methods suffer from limited availability, donor shortage, and the risk of immune rejections. 7–9 Consequently, advanced wound dressings that can replace partial functions of skin grafts and promote wound healing are highly desirable.…”

Surface-Engineered Titanium with Nanoceria to Enhance Soft Tissue Integration Via Reactive Oxygen Species Modulation and Nanotopographical Sensing

“…16 Specifically, Ce is recognized as a promising candidate for safeguarding cells from oxidative stress linked to biological reactions such as cell damage and inflammation. 17,18 Our research group has also been at the forefront of the fabrication of Ce and other nanomaterial-tuned biomaterials for various biomedical applications. 19−22 Concurrently, the topographical features of implant surfaces play a crucial role in dictating cellular behaviors, encompassing cell adhesion, proliferation, and differentiation.…”

“…Over the years, Ce-based coatings have been extensively studied because of their capability to protect implant surfaces and inhibit oxidative corrosion . Specifically, Ce is recognized as a promising candidate for safeguarding cells from oxidative stress linked to biological reactions such as cell damage and inflammation. , Our research group has also been at the forefront of the fabrication of Ce and other nanomaterial-tuned biomaterials for various biomedical applications. − Concurrently, the topographical features of implant surfaces play a crucial role in dictating cellular behaviors, encompassing cell adhesion, proliferation, and differentiation . Introducing nanoscale modifications, such as nanotopography, can elicit enhanced cellular responses and ultimately improve tissue integration .…”

Multifunctional Molybdenum-Based Nanoclusters Engineered Gelatin Methacryloyl as In Situ Photo-Cross-Linkable Hybrid Hydrogel Dressings for Enhanced Wound Healing

“…13,14 Ultrasmall antioxidant nanoparticles (typically size <10 nm) address several key challenges associated with larger nanoparticles, such as the need to administer higher concentrations, rapid clearance, and biocompatibility issues. 15 Among other nanomaterials, polyoxometalate based ones have gained recent interest due to their diverse structures, sizes, metal combinations, high water solubility, and significant redox chemistry. 16 This versatility makes them highly regarded in medicine, leading to their widespread use in various biomedical applications such as antitumor, antimicrobial, and antioxidant therapy.…”