Zn-doping enhances the photoluminescence and stability of PbS quantum dots for in vivo high-resolution imaging in the NIR-II window

Shi, Xiulei; Chen, Song; Luo, Mengyao; Huang, Biao; Zhang, Guozhen; Cui, Ran; Zhang, Mingxi

doi:10.1007/s12274-020-2843-4

Cited by 35 publications

(19 citation statements)

References 44 publications

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“…A one‐step hot‐injection method was employed to dope Mn (II) ions into Ag 2 Se QDs. [ 52,53 ] Briefly, silver acetate (AgAc), manganese (II) acetate tetrahydrate (Mn(Ac) 2 ), 1‐dodecanethiol (DT), and 1‐octadecene (ODE) were mixed under argon flow. DT, which has a long alkyl chain, was adopted as the capping ligand to improve the colloidal stability of the products.…”

Section: Resultsmentioning

confidence: 99%

“…CCK‐8 method was used to study the cytotoxicity of Mn‐doped nanoprobes. [ 52 ] 4T1 cells and human immortalized oral epithelial cells (HIOEC) were planted in 96‐well plates (5 × 10 4 cells per well) and cultured in an incubator containing 5% carbon dioxide and humid gas at 37 °C for 24 h. The culture medium was replaced with fresh 1640 medium containing 5, 15, 30, and 50 µg mL −1 Mn‐doped nanoprobes. Finally, the cell viability was calculated according to the absorbance measured at 450 nm.…”

Section: Methodsmentioning

confidence: 99%

“…PLQYs of both the undoped Ag 2 Se QDs and Mn‐doped Ag 2 Se QDs were measured using a standard organic dye ICG of known PLQY ( Φ = 0.13 in DMSO) as reported previously. [ 52 ]…”

Section: Methodsmentioning

confidence: 99%

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An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity

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Adv Healthcare Materials

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Currently, radiotherapy (RT) is the main method for cancer treatment. However, the hypoxic environment of solid tumors is likely to cause resistance or failure of RT. Moreover, high‐dose radiation may cause side effects to surrounding normal tissues. In this study, a new type of nanozyme is developed by doping Mn (II) ions into Ag2Se quantum dots (QDs) emitting in the second near‐infrared window (NIR‐II, 1000–1700 nm). Through the catalysis of Mn (II) ions, the nanozymes can trigger the rapid decomposition of H2O2 and produce O2. Conjugated with tumor‐targeting arginine‐glycine‐aspartate (RGD) tripeptides and polyethylene glycol (PEG) molecules, the nanozymes are then constructed into in vivo nanoprobes for NIR‐II imaging‐guided RT of tumors. Owing to the radiosensitive activity of the element Ag, the nanoprobes can promote radiation energy deposition. The specific tumor‐targeting and NIR‐II emitting abilities of the nanoprobes facilitate the precise tumor localization, which enables precise RT with low side effects. Moreover, their ultra‐stability in the living body ensures that the nanoprobes continuously produce oxygen and relieve the hypoxia of tumors to enhance RT efficacy. Guided by real‐time and high‐clarity imaging, the nanoprobe‐mediated RT promotes anti‐tumor immunity, which significantly inhibits the growth of tumors or even cures them completely.

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Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity

Wang

Huang

et al. 2021

Adv Healthcare Materials

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“…[36,37] Zn-doped PbS with high QY (about 50%, two times more than undoped PbS) in NIR-II region and Zn dopants improved photoluminescence lifetime (Figure 1d). [24] In addition, silica and amphiphilic polymer dual-coating can effectively improve the stability and biocompatibility of QDs, imparting them high stability under various chemical conditions including strong acid solution. [38] Qian and co-workers modified PbS/CdS with double layer modified SiO 2 /F-127 to prepare NIR-II imaging probe with high biocompatibility and photostability (QY = 5.79%), and successfully achieved real-time monitoring of cerebral blood flow in mice.…”

Section: Qdsmentioning

confidence: 99%

Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

Wang

Wan

et al. 2021

Small

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Optical imaging in the second near infrared region (NIR‐II, 1000–1700 nm) provides higher resolution and deeper penetration depth for accurate and real‐time vascular anatomy, blood dynamics, and function information, effectively contributing to the early diagnosis and curative effect assessment of vascular anomalies. Currently, NIR‐II optical imaging demonstrates encouraging results including long‐term monitoring of vascular injury and regeneration, real‐time feedback of blood perfusion, tracking of lymphatic metastases, and imaging‐guided surgery. This review summarizes the latest progresses of NIR‐II optical imaging for angiography including fluorescence imaging, photoacoustic (PA) imaging, and optical coherence tomography (OCT). The development of current NIR‐II fluorescence, PA, and OCT probes (i.e., single‐walled carbon nanotubes, quantum dots, rare earth doped nanoparticles, noble metal‐based nanostructures, organic dye‐based probes, and semiconductor polymer nanoparticles), highlighting probe optimization regarding high brightness, longwave emission, and biocompatibility through chemical modification or nanotechnology, is first introduced. The application of NIR‐II probes in angiography based on the classification of peripheral vascular, cerebrovascular, tumor vessel, and cardiovascular, is then reviewed. Major challenges and opportunities in the NIR‐II optical imaging for vascular imaging are finally discussed.

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“…Lead sulfide (PbS) quantum dots (QDs) have exhibited the advantages of high fluorescence brightness and tunable emission wavelength [34][35][36] for noninvasive high-performance in vivo imaging in the NIR-II window. 14,18,33,37,38 We designed and synthesized a series of PbS/CdS core-shell quantum dots (CSQDs), and then hydrated them with polyethylene glycol (PEG).…”

Section: Introductionmentioning

confidence: 99%

Perfecting and extending the near-infrared biological window

Feng

Tang

et al. 2021

Preprint

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In vivo fluorescence imaging in the second near-infrared window (NIR-II) has been considered as a promising technique for visualizing the mammals. However, the definition of the NIR-II region and the mechanism accounting for the excellent performance still need to be perfected. Herein, we simulated bioimaging in the NIR spectral range (to 2340 nm), confirmed the positive contribution of moderate light absorption by water in intravital imaging and perfected the NIR-II window as 900-1880 nm, where the 1400-1500 nm was defined as NIR-IIx region and the 1700-1880 nm was defined as NIR-IIc region, respectively. Moreover, the 2080-2340 nm was newly proposed as the third near-infrared (NIR-III) window, which was believed to provide the best imaging quality. The wide-field fluorescence microscopy in brain, in addition, was performed around NIR-IIx region with excellent optical sectioning strength and the largest imaging depth of in vivo NIR-II fluorescence microscopy to date. We also proposed 1400 nm long-pass detection in off-peak NIR-II imaging whose profits exceeded those of NIR-IIb imaging, using bright fluorophores with short peak emission wavelength.

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Zn-doping enhances the photoluminescence and stability of PbS quantum dots for in vivo high-resolution imaging in the NIR-II window

Cited by 35 publications

References 44 publications

An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity

An Ultra‐Stable, Oxygen‐Supply Nanoprobe Emitting in Near‐Infrared‐II Window to Guide and Enhance Radiotherapy by Promoting Anti‐Tumor Immunity

Optical Imaging in the Second Near Infrared Window for Vascular Bioimaging

Perfecting and extending the near-infrared biological window

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