property, subsequent thermomechanical treatments have to be used for sintered products, including hipping and hot The eVect of iron on the sintering behaviour of forging.4,5 titanium powder was investigated from two aspects:To make more eYcient use of these bene ts in the BE (1) diVusional homogenisation of iron; (2) densi cation process, some new titanium alloys were developed, including of Ti-5Fe alloy. Under the present process conditions Ti-5Al-2Cr-1Fe,6 Ti-6·8Mo-4·2Fe-1·4Al-1·4V (Ref . 7) and ( heating rate of 5 K minÕ 1 and iron content 5 wt-%),Ti-4·5Al-3V-2Fe-2Mo.8 In these titanium alloys, Fe was iron dissolved into the titanium matrix thoroughly added to substitute partially more expensive vanadium. before the rst eutectic temperature; potential liquid Majima et al.9 studied the eVect of diVerent iron content phase did not appear. The addition of iron enhances the on the sintered density, microstructure and tensile properties sinterability of titanium alloys because the mobility of of pure titanium powder. The eVect of iron on the microtitanium atoms is accelerated by the rapid diVusion structure and the mechanical properties of Ti-5Al-2Cr-1Fe of iron. Most sintering shrinkage is achieved during was investigated by Hagiwara et al.6 Fujita et al.10 reported the heating stage from 950 to 1250°C. Based on the that the addition of transition element Fe could achieve diVusion creep mechanism of Nabarro-Hering, the higher sintering density in Ti-4·5Al-3V-2Fe-2Mo using the result can be explained as a combination of the diVusion same sintering process as compared with Ti-6Al-4V. They coeYcient D and inherent local sintering stress s, found that addition of iron could achieve higher sinterability and the dissolution of iron in titanium is expected to and better strength-ductility balance for titanium alloys, reduce the creep strength of the Ti matrix at high and consequently eliminate costly hipping or hot forging temperatures due to its very fast diVusion rate. The techniques. However, successful veri cation of its eVect eVect of iron on the microstructure of Ti-5Fe alloy is on the sintering behaviour of blended elemental titanium also discussed. The formation of a Widmanstättenlike alloys has not been thoroughly analysed, and a reasonable microstructure in Ti-5Fe alloy can be attributed to a mechanism regarding this eVect has not been suggested. In b stabilising eVect and a high diVusion rate of iron the present article, compared with the sintering behaviour during furnace cooling.PM/1019 of pure titanium, the densi cation mechanism and microstructure evolution of Ti-Fe alloy (iron content=5 wt-%)
EXPERIMENTALThe characteristics of raw powders used in the experiment are listed in Table 1. Hydride-dehydride pure titanium powder and pure iron powder were blended in an attritor
INTRODUCTIONfor 30 min, followed by uniaxial die pressing to a relative Titanium alloys have various advantages over ferrous and density of 86% and sintering at 1250°C for 3 h in a vacuum non-ferrous materials, such as high strength to wei...
Monitoring specific immune cells in vivo will provide significant information for improving the therapeutic effect of immunotherapy. Herein, the in vivo twocolor fluorescence molecular imaging of an important immune cell, myeloid-derived suppressor cell (MDSC), was realized by using quantum dot (QD)-based nanoprobes with non-overlap emission in the second near-infrared window (NIR-II, 1000−1700 nm). NIR-IIa and NIR-IIb QDs were conjugated with two MDSC-specific antibodies, respectively, and targeted the in vivo MDSCs together. Due to the suppressed photon scattering and diminished autofluorescence in the NIR-II window, the distribution of MDSCs in different organs and tissues was clearly revealed in a non-invasive way by the colocalization of two-color fluorescence from nanoprobes. The high-resolution imaging further confirmed the exact distribution of MDSCs in tumor immune microenvironment (TIME). Our results demonstrated that NIR-II fluorescence nanoprobes with molecular targeting ability provided a powerful tool for monitoring the dynamic change of immune cell populations in TIME in vivo, thus guiding the choice of clinical medicine and evaluating the therapeutic effect.
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